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National Repository of Grey Literature 2 records found  Search took 0.01 seconds. 
Důsledky antiarytmických léčiv na srdeční energetiku
 Převorovská, Světlana ; Maršík, František
The numerical model of the human cardiovascular system of pulsating type imitating the electrochemical and mechanical activity of the heart muscle was used to the simulation of the antiarrhythmic drugs on cardiac energy parameters. The numerical model developed at the Institute of Thermomechanics CAS gives the information about the antiarrhythmic drugs effects on cardiac energy parameters such as myocardial oxygen consumption, left ventricle stroke work. Cardiac oxygen demand is closely related to the cardiac afterload and therefore major goal of therapeutic treatment by way of antiarrhythmics use is to reduce systemic blood pressure.
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Voltage and frequency dependent block of sodium current in cardiac cells. Comparison of the effect of two antiarrhythmic drugs
 Matějovič, P. ; Bahníková, M. ; Pásek, Michal ; Šimurdová, M. ; Šimurda, J.
Ionic currents recorded in voltage clamp experiments on enzymatically isolated rat ventricular myocytes were analyzed with the aim to study the voltage and frequency dependence of sodium current block induced by two antiarrhythmic drugs: ajmaline and propafenone. The levels of block produced by both examined agents were clearly related to membrane voltage. Interestingly, ajmaline, in contrast to propafenone, did not show frequency and use dependent effect. These differences are analyzed.
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