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Distribution of pharmaceuticals in wastewater treatment plants
Šilhánková, Lenka ; Čáslavský, Josef (referee) ; Vávrová, Milada (advisor)
This bachelor’s thesis deals with a trending topic – wastewater distribution of pharmaceuticals proven to be toxic to non-target organisms – specifically, the occurrence of beta-blockers, plentifully used in treating hypertension and other cardiovascular diseases, is discussed. Members of this group, Atenolol, Acebutolol and Bisoprolol were chosen for closer study. The elimination of these chemicals was observed in three wastewater treatment plants (WWTP) with different treatment technologies and various number of population equivalents. For said analytes, UHPLC with UV/VIS detection using diode array detector (DAD) method was optimalised. A part of this thesis also deals with optimalization of isolation and concentrating the analytes. Unfortunately, the described method was not suitable for real sample analysis, because in most samples, the limit of quantification or even the limit of detection was not exceeded. It would be best for an analytical method with higher sensitivity, e. g. mass detector, to be used. The data gained in this experiment do not hold any informational value about the effectiveness of WWTP, as the exact amount of Acebutolol in effluent was measured only in one case. Based on the to-date executed analysis, it is impossible to conclude whether the quality of the treated water, concerning the content of aforementioned pharmaceuticals, is in any way ideal.
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Distribution of pharmaceuticals in wastewater treatment plants
Šilhánková, Lenka ; Čáslavský, Josef (referee) ; Vávrová, Milada (advisor)
This bachelor’s thesis deals with a trending topic – wastewater distribution of pharmaceuticals proven to be toxic to non-target organisms – specifically, the occurrence of beta-blockers, plentifully used in treating hypertension and other cardiovascular diseases, is discussed. Members of this group, Atenolol, Acebutolol and Bisoprolol were chosen for closer study. The elimination of these chemicals was observed in three wastewater treatment plants (WWTP) with different treatment technologies and various number of population equivalents. For said analytes, UHPLC with UV/VIS detection using diode array detector (DAD) method was optimalised. A part of this thesis also deals with optimalization of isolation and concentrating the analytes. Unfortunately, the described method was not suitable for real sample analysis, because in most samples, the limit of quantification or even the limit of detection was not exceeded. It would be best for an analytical method with higher sensitivity, e. g. mass detector, to be used. The data gained in this experiment do not hold any informational value about the effectiveness of WWTP, as the exact amount of Acebutolol in effluent was measured only in one case. Based on the to-date executed analysis, it is impossible to conclude whether the quality of the treated water, concerning the content of aforementioned pharmaceuticals, is in any way ideal.
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