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Quality of life in renal transplant recipients and the possibilities of its affecting through different forms of intervention
Králová, Helena ; Mahrová, Andrea (advisor) ; Vaňous, František (referee)
Title: Quality of life in renal transplant recipients and the possibilities of its affecting through different forms of intervention. Aims: 1) To evaluate quality of life in renal transplant recipients and compare it with that of the general population. 2) To analyze effects of a 6 months controlled intervention exercise program, special diet, combination of special diet and exercise program and control group on the health related quality of life and to compare results between groups. Methods: We studied a composite group of 21 patients (mean age 58,4 9,34 years) after renal transplantation. Patients were randomly divided into four groups, each group had different program, as described above. The assessment of the quality of life was performed twice, before and after six months of a regular intervention program. We used standardized questionnaires KDQOL-SFTM . We have also assessed the importance of individual dimensions of quality of life with questionnaire WHOQOL - 100. Results were analyzed using descriptive statistics, non-parametric Wilcoxon signed-rank test and non-parametric Kruskal Wallis test. Statistically significance was considered on p ≤ 0,05. Results: After the pre-test and evaluation of the quality of life we assessed, that from 8 dimensions there were 5 lower after the...
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Biomarkers of early renal injury
Fořtová, Magdaléna ; Průša, Richard (advisor) ; Kalousová, Marta (referee) ; Ryšavá, Romana (referee)
Aims: The thesis deals with the biomarkers of early renal injury, namely albuminuria and neutrophil gelatinase-associated lipocalin (NGAL). The aims in the case of albuminuria were the implementation of HPLC method, comparing HPLC with immunoturbidimetric (IT) method and monitoring the relationship to the diagnosis of diabetes mellitus. The aim of urinary NGAL (and eventually other markers) examination was to verify its reliability in the prediction of acute kidney injury (AKI). Methods: We investigated albuminuria in fresh urine samples in the groups of 636 diabetics and 456 nondiabetics using the HPLC method (Agilent 1200, Agilent Technologies, USA) and immunoturbidimetrically (Cobas Integra 400, Roche Diagnostics); we studied the correlations and relationships between albuminuria and glycated hemoglobin HbA1c. We investigated urinary NGAL by chemiluminescent microparticle immunoassay (Architect i4000, Abbott) in children's groups: 1) after renal transplantation (N = 15), 2) with acute or chronic kidney disease (N = 28); and in adult patient's groups: 1) after cardiac surgery (N = 10) and 2) post angiography (N = 41). Results: Albuminuria determined by HPLC was statistically significantly higher than albuminuria determined by IT. We excluded nonspecificity of the HPLC method. Results indicate...
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Physical, mental and social integrity of renal transplant recipients.
Štollová, Milena ; Kulhavá, Miluše (advisor) ; Pírková, Vendula (referee)
The thesis for a baccalaureate degree addresses the topic of overall wellbeing of the renal transplant recipient. It is divided into a theoretical and an empirical section. The theoretical section discusses the status of the patient with irreversible kidney failure whereby the method is transplantation. The outputs for the empirical section derive from a questionnaire-based survey performed with 113 adult transplant recipients once their renal transplant function has stabilized. The aim of the thesis was to compare parameters of renal function and physical condition with overall quality of life. After having defined five partial goals, a survey was conducted using non-standardized questionnaires. Its results were compared with renal markers and data obtained from standardized questionnaires. The partial goals related to physical and psychical condition, sleep, concerns about one's future, and a socio-spiritual component. The quality of life was found to be inferior to that seen in the general population. No correlation was demonstrated between renal function markers on the one hand, and physical and psychical condition on the other. Individuals experiencing more immune system-related complications (rejection) only reported more tangible support from family and friends. Quite logically, the fact...
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Physical activity after the renal transplantation
Sýsová, Alena ; Mahrová, Andrea (advisor) ; Bartůňková, Staša (referee)
Introduction: Thanks to modern medicine people with chronic forms of the diseases can live longer than before. In this work we concerned with last stage of chronical kidney dinase, which is treated by dialysis or transplantation. Succesful renal transplantation leads to significant improvement in quality of life of patients, but after transplantation there are still some risk factors, which may influence health and physical condition of men. We can eliminace these risk factors with some non-pharmacological ways, for example with intervention program of regular physical activity and special nutrition, which can help to gain and increase patient`s physical condition. The main focus of research of this thesis was to evaluate physical condition and amount of physical aktivity of 4 groups of patients, each with another intervention, after renal transplant. We used the battery of motor tests "Senior Fitness Test Manual". Aim: Analyze, how regular physical activity, special nutrition and combination of both influence physical condition of patients after renal transplant. Methods: This research work is a part of the grant project IGA MZ CR 173 (NS-10518- 3/2009). We used 21 participants selected from patients of Nephrology Clinic TC IKEM in Prague for our solution. Physical fitness testing was performed...
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Quality of life in renal transplant recipients and the possibilities of its affecting through different forms of intervention
Králová, Helena ; Mahrová, Andrea (advisor) ; Vaňous, František (referee)
Title: Quality of life in renal transplant recipients and the possibilities of its affecting through different forms of intervention. Aims: 1) To evaluate quality of life in renal transplant recipients and compare it with that of the general population. 2) To analyze effects of a 6 months controlled intervention exercise program, special diet, combination of special diet and exercise program and control group on the health related quality of life and to compare results between groups. Methods: We studied a composite group of 21 patients (mean age 58,4 9,34 years) after renal transplantation. Patients were randomly divided into four groups, each group had different program, as described above. The assessment of the quality of life was performed twice, before and after six months of a regular intervention program. We used standardized questionnaires KDQOL-SFTM . We have also assessed the importance of individual dimensions of quality of life with questionnaire WHOQOL - 100. Results were analyzed using descriptive statistics, non-parametric Wilcoxon signed-rank test and non-parametric Kruskal Wallis test. Statistically significance was considered on p ≤ 0,05. Results: After the pre-test and evaluation of the quality of life we assessed, that from 8 dimensions there were 5 lower after the...
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