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Metabolism of benzo [a] pyrene by the lung cells of a patient with cystic fibrosis
Skořepová, Adéla ; Indra, Radek (advisor) ; Wilhelm, Marek (referee)
Cancer is the most common disease, killing several million people worldwide each year. There are many reasons for its occurrence. The most common causes of cancer include alcohol and tobacco use. Nowadays, there is also a higher incidence of physical and chemical carcinogens that interfere with the environment. Poor eating habits and lack of exercise are also influential. Nowadays, thanks to good medical care, improved diagnostics and, above all, a number of existing vaccines, cancer is partly preventable. In the future, it is safe to say that cancer will increase. According to the IARC, over 19.3 million new cases will be diagnosed worldwide in 2020. By 2040, it is estimated that there will be another 10.9 million. Cystic fibrosis is an autosomal recessive inherited disease that affects 1 in 2500 newborns in the population. The main cause is impaired function of the CFTR protein as a transmembrane regulator of cystic fibrosis, leading to impaired fluid transport and impermeability of chloride ions, with a combination of excessive sodium absorption, leading to reduced water content in the periciliary fluid. People with cystic fibrosis are much more susceptible to colon cancer, especially those who have undergone lung transplantation. In recent years, the treatment of patients with cystic fibrosis...
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