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Application for the Data Processing in the Area of Evolutionary Biology
Vogel, Ivan ; Burgetová, Ivana (referee) ; Očenášek, Pavel (advisor)
Phylogenetic tree inference is a very common method for visualising evolutionary relationships among species. This work focuses on explanation of mathematical theory behind molecular phylogenetics as well as design of a modified algorithm for phylogenetic tree inference based on intra-group analysis of nucleotide and amino acid sequences. Furthermore, it describes the object design and implementation of the proposed methods in Python language, as well as its integration into powerful bioinformatic portal. The proposed modified algorithmic solutions give better results comparing to standard methods, especially on the field of clustering of predefined groups. Finally, future work as well as an application of proposed methods to other fields of information technology are discussed.
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Techniques for Multiple Sequence Alignments
Hrazdil, Jiří ; Martínek, Tomáš (referee) ; Burgetová, Ivana (advisor)
This thesis summarizes ways of representation of biological sequences and file formats used for sequence exchange and storage. Next part deals with techniques used for sequence pairwise alignment, followed by extension of these techniques to the problem of multiple sequence alignment. Additional methods are introduced, that are suboptimal, but on the other hand are able to compute results in reasonable time. Practical part of this thesis consists of implementing multiple sequence alignment application in Java programming language.
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Techniques for Multiple Sequence Alignments
Hrazdil, Jiří ; Martínek, Tomáš (referee) ; Burgetová, Ivana (advisor)
This thesis summarizes ways of representation of biological sequences and file formats used for sequence exchange and storage. Next part deals with techniques used for sequence pairwise alignment, followed by extension of these techniques to the problem of multiple sequence alignment. Additional methods are introduced, that are suboptimal, but on the other hand are able to compute results in reasonable time. Practical part of this thesis consists of implementing multiple sequence alignment application in Java programming language.
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Application for the Data Processing in the Area of Evolutionary Biology
Vogel, Ivan ; Burgetová, Ivana (referee) ; Očenášek, Pavel (advisor)
Phylogenetic tree inference is a very common method for visualising evolutionary relationships among species. This work focuses on explanation of mathematical theory behind molecular phylogenetics as well as design of a modified algorithm for phylogenetic tree inference based on intra-group analysis of nucleotide and amino acid sequences. Furthermore, it describes the object design and implementation of the proposed methods in Python language, as well as its integration into powerful bioinformatic portal. The proposed modified algorithmic solutions give better results comparing to standard methods, especially on the field of clustering of predefined groups. Finally, future work as well as an application of proposed methods to other fields of information technology are discussed.
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