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Nuclear Transport Signals in the proteins of the ARP2/3 complex
Němcová, Barbora ; Bellinvia, Erica (advisor) ; Cvrčková, Fatima (referee)
The intracellular movement of macromolecules such as proteins and RNA is essential for maintaining cellular homeostasis and coordinating various cellular processes. In eukaryotic cells, the transport of these molecules between the cytoplasm and the nucleus is carefully regulated. Nuclear transport signals (NTS) play a key role in facilitating the import and export of proteins across the nuclear envelope. The ARP2/3 complex, which is an important regulator of activity dynamics, has been studied mainly for its functions in the cytoplasm, such as cell movement and cell division. However, new findings suggest that the ARP2/3 complex might also have nuclear functions in plants. Plants are unique multicellular organisms that rely on precisely coordinated cellular activities for growth, development, and response to stimuli. Understanding the molecular mechanisms behind nuclear processes in plants has recently become a focus of research. The ARP2/3 complex, which consists of seven subunits, is known for its ability to branch actin filaments and thereby control cellular processes requiring actin remodeling. However, recent studies have revealed a potential link between the ARP2/3 complex and nuclear functions in plants. Proteins associated with the ARP2/3 complex have been found to localize within the plant...
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The neuropsychological development screeing NES:Further testing of the czech version
Jantová, Alžběta ; Šturma, Jaroslav (advisor) ; Šírová, Eva (referee)
Neuropsychological developmental screening (NES) is a German tool (published in 2005) for assessing eight fields of development of children aged 3 to 24 months. It is designed for pediatritians, early intervention specialists and psychologists. This thesis builds on A. Klapetek's thesis and aims to verify and check accurancy of Czech translation of the tool by administring the test to a group of Czech children. A. Klapetek conducted a pilot study of the tool. 50 children (10 for every age group) were administred the translation which was being refined during the field research. She also planned further steps to applying NES. Literature review of the thesis deals with developmental characteristics of infants and toddlers. Psychological assessment of young children and its uses and risks are described. The thesis also persues developmental scales, their history and present state. Theoretical concept of the Neuropsychological developmental screening (NES) is introduced. During the field research a group of 50 children was assessed by Czech translation of the tool, and the same group was tested by Developmental screening (Kovařík). Results of the testing were used to discuss existing norms of the tool, to identify problematic exercises (both too difficult and too easy) and to statistically analyse...
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