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Human polyomavirus isolated from Merkel cell carcinoma
 Vochozková, Petra ; Šroller, Vojtěch (advisor) ; Španielová, Hana (referee)
Human polyomaviruses belong to the Polyomaviridae family. Until now, five human polyomaviruses (BK, JC, KI, WU and MCV) have been discovered. There is described the course of polyomavirus infection in the first part of the thesis. These small nonenveloped viruses penetrate into the host cell by receptor-mediated endocytosis and then travel through the ER pathway to get into the nucleus where the virus replicates and expresses viral proteins. The infection occurs during early childhood and the virus remains asymptomatic in healthy individuals. However, the virus is able to reactivate in the immunosuppressed patients and can cause some diseases. The second part of thesis is focused on the MCV. MCV genom was detected in Merkel cell carcinoma (MCC) two years ago. MCV infects the Merkel cells and its DNA integrates into host cell genome. In most cases, the MCV is detected in cancer cells using PCR. Viral sequences encoding the large and small T antigen were found in the MCC using the same method; moreover, there was expressed a significant amount of oncoproteins. These factors point out an important role of MCV in the tumor progress. The study of MCV may help to discover new approaches for the treatment of MCC and other biologically similar tumors.
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