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National Repository of Grey Literature 2 records found  Search took 0.00 seconds. 
Immunomodulation using two types of ligands
 Adámek, David ; Bezouška, Karel (advisor) ; Pompach, Petr (referee)
CD69 and NKR-P1 are receptors belonging to C-lectin family of receptors. We have recently identified two types of effective ligands for these receptors: dimeric N-acetyl-D-glukosamines (activators) and (calix[4]arenes) inhibitors. By using them, we can modulate immune response. First class of ligands (N-acetyl-D-glukosamines) is able to bind to CD69 and NKR-P1 and activate the cells. Second class of ligands (calix[4]arenes) is able to effectively inhibit functions of CD69, but not functions of NKR-P1. The aim of this study was to learn how to modulate immune response by various combinations of these compounds, and to explore their concentrations suitable for tumor therapies. Effect of used ligand and their combinations was studied in standard tests of cell proliferation, cell death and cytotoxic killing.
Detailed record
Immunomodulation using two types of ligands
 Adámek, David ; Pompach, Petr (referee) ; Bezouška, Karel (advisor)
CD69 and NKR-P1 are receptors belonging to C-lectin family of receptors. We have recently identified two types of effective ligands for these receptors: dimeric N-acetyl-D-glukosamines (activators) and (calix[4]arenes) inhibitors. By using them, we can modulate immune response. First class of ligands (N-acetyl-D-glukosamines) is able to bind to CD69 and NKR-P1 and activate the cells. Second class of ligands (calix[4]arenes) is able to effectively inhibit functions of CD69, but not functions of NKR-P1. The aim of this study was to learn how to modulate immune response by various combinations of these compounds, and to explore their concentrations suitable for tumor therapies. Effect of used ligand and their combinations was studied in standard tests of cell proliferation, cell death and cytotoxic killing.
Detailed record

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