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Drug interactions of gastrointestinal drugs
 Lapka, Marek ; Malý, Josef (advisor) ; Marešová, Helena (referee)
Drug interactions of gastrointestinal remedies Author: Marek Lapka Tutor: Josef Malý1 1 Department of Clinical and Social Pharmacy, Charles University in Prague, Faculty of Pharmacy in Hradec Králové Background: Drug interactions may be a serious cause of toxicity and undesirable drug effects. There is a direct proportion to side effect incidence caused by drug interactions and number of used drugs. The issue is a significant constituent of pharmaceutical care. The aim of dissertation: The aim of the thesis was to process available information, suggest a posible solution and create compact overview which can be taken into consideration by pharmacist in order to achieve optimal pharmacotherapy. Methods: Drug combinations, which interactions had clinical evaluation from "moderate severity" to "major severity" were collected from the fundamental information source, Vademecum infopharm aplication. Only currently registered drugs to 1st September 2013 by State Institute for Drug Controle were chosen and then medicinal products of which route of administration enables systemic effect. Furthermore the combination was compared with Micromedex database or Stockley's Drug Interactions Pharmaceutical Press, or both. Pubmed database (www.pubmed.gov) with entering key words "drug interaction", "basic drug" and...
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