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Surface active compounds and evaluation of its properties
Lanzendorfová, Jana ; Holas, Ondřej (advisor) ; Paraskevopoulos, Georgios (referee)
Charles University, Faculty of Pharmacy in Hradec Králové Department of Pharmaceutical Technology Mentor: PharmDr. Ondřej Holas, PhD. Consultant: PharmDr. Jan Marek, PhD. Student: Jana Heinrichová Title of Thesis: Surface active compounds and evaluation of its properties The theoretical part of the thesis is focused on the properties of surfactants, their distribution, and their use. In this part, micelles, critical micelle concentration, methods of its determination and factors influencing it are also characterized. In the experimental part, the critical micelle concentration (CMC) of two homologous series of quaternary ammonium salts (benzalkonium chlorides and benzoxonium chlorides) was evaluated by a conductometric method. Several parameters (side chain length, temperature, pH) and their influence on the critical micelle concentration value were monitored. Furthermore, the critical micelle concentration of these substances was measured using a Wilhelmy plate to compare the two methods. The relationship between decreasing critical micelle concentration value and increasing alkyl chain length was verified. At the same time, the dependence of CMC on temperature and pH change was verified. Finally, the conductometric method of CMC determination was compared with the Wilhelmy plate method, and their...
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Surface active compounds and evaluation of its properties
Heinrichová, Jana ; Holas, Ondřej (advisor) ; Paraskevopoulos, Georgios (referee)
Charles University, Faculty of Pharmacy in Hradec Králové Department of Pharmaceutical Technology Mentor: PharmDr. Ondřej Holas, PhD. Consultant: PharmDr. Jan Marek, PhD. Student: Jana Heinrichová Title of Thesis: Surface active compounds and evaluation of its properties The theoretical part of the thesis is focused on the properties of surfactants, their distribution, and their use. In this part, micelles, critical micelle concentration, methods of its determination and factors influencing it are also characterized. In the experimental part, the critical micelle concentration (CMC) of two homologous series of quaternary ammonium salts (benzalkonium chlorides and benzoxonium chlorides) was evaluated by a conductometric method. Several parameters (side chain length, temperature, pH) and their influence on the critical micelle concentration value were monitored. Furthermore, the critical micelle concentration of these substances was measured using a Wilhelmy plate to compare the two methods. The relationship between decreasing critical micelle concentration value and increasing alkyl chain length was verified. At the same time, the dependence of CMC on temperature and pH change was verified. Finally, the conductometric method of CMC determination was compared with the Wilhelmy plate method, and their...
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Cationic surface active compounds and evaluation of its properties
Pekařová, Kateřina ; Nováková, Veronika (advisor) ; Kuchařová, Monika (referee)
Charles University Faculty of Pharmacy in Hradec Králové Department of Biophysics and Physical Chemistry Consultant: PharmDr. Jan Marek, Ph.D. Supervisor: doc. PharmDr. Veronika Nováková, Ph.D. Student: Kateřina Pekařová Title of Thesis: Cationic surface active compounds and evaluation of its properties Quaternary ammonium salts are used as surfactants in many branches of the food, pharmaceutical and chemical industries. The basic properties of these substances were studied in the thesis. The critical micellar concentration of the homologous series of five substances was determined using the conductometric method. The theory of declining critical micellar concentration with the increasing length of the side alkyl chain has been verified. The hydrolytic activity of two commonly used cationic surfactants benzalconium chloride and benzoxonium chloride for the decomposition of the organophosphorus pesticide fenitrothion was tested. For these two substances, the effect of pH and temperature changes was evaluated. The influence of tenside concentration was also monitored. Benzoxonium chloride at 50 řC and pH 11was found as the most effective hydrolytic catalyst for the decomposition of the organophosphorus pesticide fenitrothione.
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Cationic surface active compounds and evaluation of its properties
Pekařová, Kateřina ; Nováková, Veronika (advisor) ; Kuchařová, Monika (referee)
Charles University Faculty of Pharmacy in Hradec Králové Department of Biophysics and Physical Chemistry Consultant: PharmDr. Jan Marek, Ph.D. Supervisor: doc. PharmDr. Veronika Nováková, Ph.D. Student: Kateřina Pekařová Title of Thesis: Cationic surface active compounds and evaluation of its properties Quaternary ammonium salts are used as surfactants in many branches of the food, pharmaceutical and chemical industries. The basic properties of these substances were studied in the thesis. The critical micellar concentration of the homologous series of five substances was determined using the conductometric method. The theory of declining critical micellar concentration with the increasing length of the side alkyl chain has been verified. The hydrolytic activity of two commonly used cationic surfactants benzalconium chloride and benzoxonium chloride for the decomposition of the organophosphorus pesticide fenitrothion was tested. For these two substances, the effect of pH and temperature changes was evaluated. The influence of tenside concentration was also monitored. Benzoxonium chloride at 50 řC and pH 11was found as the most effective hydrolytic catalyst for the decomposition of the organophosphorus pesticide fenitrothione.
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Cationic surface active compounds and evaluation of its properties
Pekařová, Kateřina ; Nováková, Veronika (advisor) ; Kuchařová, Monika (referee)
Charles University Faculty of Pharmacy in Hradec Králové Department of Biophysics and Physical Chemistry Consultant: PharmDr. Jan Marek, Ph.D. Supervisor: doc. PharmDr. Veronika Nováková, Ph.D. Student: Kateřina Pekařová Title of Thesis: Cationic surface active compounds and evaluation of its properties Quaternary ammonium salts are used as surfactants in many branches of the food, pharmaceutical and chemical industries. The basic properties of these substances were studied in the thesis. The critical micellar concentration of the homologous series of five substances was determined using the conductometric method. The theory of declining critical micellar concentration with the increasing length of the side alkyl chain has been verified. The hydrolytic activity of two commonly used cationic surfactants benzalconium chloride and benzoxonium chloride for the decomposition of the organophosphorus pesticide fenitrothion was tested. For these two substances, the effect of pH and temperature changes was evaluated. The influence of tenside concentration was also monitored. Benzoxonium chloride at 50 řC and pH 11was found as the most effective hydrolytic catalyst for the decomposition of the organophosphorus pesticide fenitrothione.
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