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National Repository of Grey Literature 2 records found  Search took 0.01 seconds. 
Porfyrie
 ŠTEFKOVÁ, Michaela
This work summarises the causes of formation of a group of rare but serious diseases called Porphyria. This paper specifies the particular forms of these diseases and focuses mainly on their diagnostics. Typical symptoms and possible cures are assigned to each form of Porphyria.
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Evolution of the tetrapyrrole synthesis in eukaryotes
 KOŘENÝ, Luděk
This thesis focuses on the nature of heme metabolism in various eukaryotes. One of the aims was the elucidation of the origin of the unique heme biosynthesis pathway in apicomplexan parasites through a comparative study of their photosynthetic relative Chromera velia combining molecular biology, biochemistry and bioinformatics approach. Using similar strategy, I have also investigated the origin and spatial organization of tetrapyrrole biosynthesis in Euglena gracilis. Based on the phylogenetic data I described the complex evolution of heme metabolism in kinetoplastid flagellates including pathogenic trypanosomes. I revealed that one of them (Phytomonas) does not require heme for viability by the combination of various biochemical and molecular biology experiments and bioinformatic analyses.
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