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Mental development of children with low birth weight
Švandová, Lucie ; Ptáček, Radek (advisor) ; Fischer, Slavomil (referee) ; Myšková, Lucie (referee)
Introduction: There is a high prevalence of cognitive and socioemotional dysfunction and disorders in very low birth weight (VLBW <1500 g) and extremely low birth weight (ELBW <1000 g) children. These findings raise concerns and questions about the level of mental development of these children, not only in early childhood but also during school age, adolescence and adulthood. Methods: Socioemotional and cognitive development was assessed in 118 children with VLBW or ELBW and 101 children with normal birth weight (≥ 2 500 g), aged 5 to 9 years. The test battery contained selected subscales from the Intelligence and Development Scales (IDS) and the Developmental Neuropsychological Assessment - second edition (NEPSY-II). Parents were administered Behaviour Rating Inventory of Executive Function (BRIEF), and an anamnestic interview as well as observation was also conducted. Results: A statistically significant difference in cognitive and socioemotional development between children with VLBW/ELBW and children with normal birth weight. The IQ score of children with normal birth weight was on average 12.98 points higher. These children also perform better results than children with VLBW/ELBW in all subtests of the IDS and NEPSY-II. Parents did not evaluate impaired executive function. Conclusion: Among...
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The impact of IGF1 and selected IGF1 gene polymorphisms on postnatal growth in children SGA/IUGR and extremely preterm newborns.
Kytnarová, Jitka ; Zeman, Jiří (advisor) ; Baxová, Alice (referee) ; Houšťková, Hana (referee)
Long-term outcome of extremely preterm neonates depends on many endogenous and exogenous factors. Long-term follow-up of extremely preterm neonates during childhood and analyses of IGF1 gene polymorphisms may help to better understand the problems connected with delayed postnatal growth and the progression of cardiovascular diseases and diabetes mellitus type 2 in adulthood. The aim was the long-term follow-up of anthropometric parameters in children born at 22−25th and 26−27th week of gestation and to study the association between postnatal growth of extremely preterm children, children small for gestational age (SGA) and children born at term with appropriate birth weight/length (AGA) and IGF1 gene polymorphisms: (CA)10-24 repetitive polymorphism in promoter, microsatellite marker D12S318 and 185 bp in 3'UTR, (CT)n polymorphism (CA)n polymorphism 216 bp in the intron 2. Methods. 242 infants born at 22-27+6 weeks were enrolled. Anthropometric parameters were measured at the ages of 2 and 5 years in 72 children born at 22-25+6 week (group I) and 85 children born at 26-27+6 week (group II). Polymorphisms of IGF1 were analysed in 51 extremely preterm, 208 AGA and 59 SGA children using fragment analyses. The data of postnatal growth data in AGA children were obtained at 18 months, in SGA and extremely...
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The impact of IGF1 and selected IGF1 gene polymorphisms on postnatal growth in children SGA/IUGR and extremely preterm newborns.
Kytnarová, Jitka ; Zeman, Jiří (advisor) ; Baxová, Alice (referee) ; Houšťková, Hana (referee)
Long-term outcome of extremely preterm neonates depends on many endogenous and exogenous factors. Long-term follow-up of extremely preterm neonates during childhood and analyses of IGF1 gene polymorphisms may help to better understand the problems connected with delayed postnatal growth and the progression of cardiovascular diseases and diabetes mellitus type 2 in adulthood. The aim was the long-term follow-up of anthropometric parameters in children born at 22−25th and 26−27th week of gestation and to study the association between postnatal growth of extremely preterm children, children small for gestational age (SGA) and children born at term with appropriate birth weight/length (AGA) and IGF1 gene polymorphisms: (CA)10-24 repetitive polymorphism in promoter, microsatellite marker D12S318 and 185 bp in 3'UTR, (CT)n polymorphism (CA)n polymorphism 216 bp in the intron 2. Methods. 242 infants born at 22-27+6 weeks were enrolled. Anthropometric parameters were measured at the ages of 2 and 5 years in 72 children born at 22-25+6 week (group I) and 85 children born at 26-27+6 week (group II). Polymorphisms of IGF1 were analysed in 51 extremely preterm, 208 AGA and 59 SGA children using fragment analyses. The data of postnatal growth data in AGA children were obtained at 18 months, in SGA and extremely...
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Early enteral nutrition in neonates with low birth weight under 1500 g
KOVANDOVÁ, Klára
This diploma thesis should sketch quantitative research of early enteral nutrition at newborns with low birth weight under 1500 grams at specialized department - neonatology in České Budějovice. Research in this diploma thesis is focused on evaluating of implemetation level according to current recommendations neonatology for the start of early enteral nutrition at premature babies. In the theoretical part of the diploma thesis we try to describe all things that include the issue of premature babies care. Next chapters deal with differences of premature baby in relation to nutrition. The nutrition of the newborn with very low birth weight is provided immediately after parenteral delivery. Quantitative research definately prefers the start of enteral nutrition in the first few hours after delivery. Goal of this strategy is to completely replace the parenteral nutrition as soon as possible. Goal of this diploma thesis is to descibe quantitative research with implementing of the enteral nutrition at newborns with birth weight under 1500 grams at specialized neonatology departments and to identify the most important differences from current recommendations for this field of care. Considering the set goal there was used the quantitative research for this diploma thesis. To get the data to create the research, secundar analysis of the data from nursing documentation of our research team was used. Through the quantitative research we try to demonstrate lack of starts with early enteral nutrition at premature babies with birth weight under 1500 grams in the 2012 and 2013. Secundar analysis of the date was made during my working experience at neonatology department in České Budějovice. Data needed for this research were systematically written into prepared chart created in Microsoft Excel. After entering all necessary data in the table, they were subsequently created graphs that reflect the real situation examined issues. After identifying the most significant differences from the current recommendations for this area of care deficiencies are subsequently provided to the department of neonatology in the České Budějovice for future improvement strategy early initiation of enteral nutrition in premature infants in this weight category, was written Decalogue of practical recommendations for optimization of enteral nutrition for preterm infants nurses working in the neonatal intensive care. The research file was created by 139 respondents (newborns with low birth weight under 1500 grams). This file is created by newborns born from 1 January 2012 to 31 December 2013 which means during two years.
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