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Endoplasmic reticulum-associated degradation and its role in virus infection
 Svobodová, Terezie ; Forstová, Jitka (advisor) ; Mašek, Tomáš (referee)
The endoplasmic reticulum-associated degradation pathway, ERAD, is an important mechanism for maintaining cellular homeostasis. The function of ERAD is degradation of accumulated unfolded proteins in the endoplasmic reticulum. ERAD is carefully regulated by pathway called "Unfold protein response" and by "ERAD tuning" mechanism. Some viruses have adopted the ways how to exploit this system or its factors for their own benefit. These utilizations include targeting of specific host proteins for degradation, transfer of viral products or virions from the endoplasmic reticulum into the cytoplasm, or the use of a membrane platform arising from the cooperation with "ERAD tuning" for viral replication. Role of ERAD in viral infection can manifest itself in different ways, it can contribute to degradation not only of host proteins but also of viral products. In this work I summarize mechanisms of ERAD pathway and their regulatory pathways. Meanwhile, in the specific examples, I present roles of ERAD pathway and associated systems in viral infections.
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