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	Termination of DNA and RNA Synthesis at the Adducts of Platinum Antitumor Compounds Nováková, Olga ; Brabec, Viktor The role of adducts of platinum antitumor compounds in the termination of DNA and RNA synthesis Detailed record
	Antitumor Efficient Platinum Complexes with Trans-Geometry and Their Reactions with DNA Neplechová, Kamila ; Kašpárková, Jana ; Prokop, Radim ; Farrell, N. ; Brabec, Viktor The reactions of antitumor efficient platinum complexes with trans-geometry with DNA Detailed record
	DNA Modifications by a New Dinuclear Platinum(II) Organometallic Complex Marini, Victoria ; Kašpárková, Jana ; Romeo, R. ; Brabec, Viktor A new dinuclear platinum(II) organometallic complex used for DNA modifications Detailed record
	Properties of 1,2-d(GpG) Intrastrand Cross-Links Formed by Platinum Complexes with Enantiomeric Amine Ligands Malina, Jaroslav ; Natile, G. ; Brabec, Viktor Studies on properties of 1,2-d(GpG) intrastrand cross-links formed by platinum complexes with enantiomeric amine ligands Detailed record
	The Impact of Interstrand Cross-link of Cisplatin or Transplatin on Thermodynamic Stability of DNA Hofr, Ctirad ; Brabec, Viktor Effects of interstrand cross-link of cisplatin or transplatin on thermodynamic stability of DNA Detailed record
	Biophysical properties of the central molecule of life Kypr, Jaroslav Detailed record
	DNA structure and its modification by antitumor compounds. Relations to the development of new drugs against cancer Brabec, Viktor Detailed record
	Identification and characterisation of genes determining embryogenesis using T-DNA mutations of Arabidopsis thaliana Dudová, M. ; Kyjovská, Z. ; Řepková, J. ; Kocábek, Tomáš Detailed record
	Konstrukce neoznačených mutantů v genech kódujících Ser/Thr proteinkinasy a fosfoproteinfosfatasu Pseudomonas aeruginosa a analýza jejich vlastností Nedvědová, Jana ; Lněnička, Petr ; Hercík, Kamil ; Branny, Pavel To investigate the importance of individual protein kinases and phosphatases in P. aeruginosa physiology we prepared the single and double mutants in the coresponding genes. Single mutants in protein kinase genes stk1, ppkB and protein phosphatase gene stp1 were prepared by the method of gene replacement with subsequent excision of antibiotic cassettes using Flp-FRT recombination system. Two-dimensional gel electrophoresis was used to analyze the patterns of phosphoproteins obtained in in vitro protein kinase assays with the cell-free lysates of wild type as well as all mutant strains. Detailed record
	Identifikace genů a proteinů, regulovaných Ser/Thr proteinkinasou Streptococcus pneumoniae, mikročipovou metodou a analýzou 2-D gelů Přenosilová, Lenka ; Nováková, Linda ; Branny, Pavel To identify the genes whose expression is controlled by protein kinase StkP we examined the transcription profile of DstkP mutant by DNA microarray technology. The transcript analysis revealed the StkP-dependent expression of many potential target loci. Out of 2,300 genes evaluated, 49 were found to be specifically and strongly upregulated in the DstkP strain, whereas 48 were downregulated. The data obtained from transcription profile were further extended by proteomic studies and mass spectrometry. Detailed record

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