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Chronotherapy as a new trend in the treatment of hypertension
Pafková, Patrícia ; Sumová, Alena (advisor) ; Alánová, Petra (referee)
Hypertension is still the leading cause of death and cardiovascular morbidity worldwide, but its long-term control remains unsatisfactory. Blood pressure is subject to certain variability during 24 hours, when its values are 10-20% lower at night than during the day. Due to the new knowledge that the circadian rhythm exists in almost all organ systems, interest in chronotherapy as a new trend in treatment is growing. This bachelor's thesis points out the importance of respecting circadian rhythms and includes current knowledge about chronotherapy of hypertension, together with an analysis of its benefits in the treatment of high blood pressure. Keywords: hypertension, circadian rhytm, antihypertensives, chronotherapy, blood pressure
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The Circadian System and Sleep in Individuals with ADHD
Nejedlý, Martin ; Skálová, Kateřina (advisor) ; Honzlová, Petra (referee)
Attention-Deficit/Hyperactivity Disorder (ADHD) is associated with sleep disorders and abnormalities of the circadian system. In recent studies, ADHD has been linked to late chronotype and delayed sleep phase disorder, clock gene polymorphisms, geographic variation in solar irradiation, longer sleep latency, and impaired sleep quality. However, research findings in children with ADHD often differ from those in adult patients. A new diagnostic category, ADHD-SOM, has been proposed to describe individuals whose symptoms are partially caused by chronic sleep issues. However, most of the evidence is correlational. The thesis summarizes research on sleep and circadian correlates of ADHD and some of the potential mechanisms explaining these associations. Chronotherapy and sleep interventions are promising methods of adjunctive ADHD treatment.
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