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Screening of biological activity of various species of the family Amaryllidaceae
Němečková, Kateřina ; Šafratová, Marcela (advisor) ; Vrabec, Rudolf (referee)
Němečková, K.: Screening of biological activity of various species of the family Amaryllidaceae. Diploma thesis, Charles University, Pharmaceutical Faculty in Hradec Králové, Department of pharmacognosy and pharmaceutical botany, Hradec Králové 2024, 70 p. Key words: Amaryllidaceae, bulbs, alkaloidal extracts, GC/MS analysis, biological activity, acetylcholinesterase, butyrylcholinesterase. The family Amaryllidaceae is irreplaceable in the natural kingdom. In folk medicine it is used to deal with simple ailments such as colds and infections. The plant species of this family are abundant in nature, the core of the action are secondary metabolites. The most important metabolites are Amaryllidaceae alkaloids, which can be categorized into groups according to their basic structure. Majority of alkaloids belonging to the Amaryllidaceae family have similar effects and are therefore intensively studied, the most promising representatives have anticancer, antibacterial, antifungal, antiviral and antimalarial activity. The abilities of alkaloids to inhibit human cholinesterases, which may have neuroprotective effects especially on cognitive decline, have also been analyzed. Assessing the biological activity and revealing the presence of new alkaloids in selected plants was the aim of this thesis. The...
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