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National Repository of Grey Literature 1 records found  Search took 0.01 seconds. 
Analysis of drug dosage adjustments in patients with chronic kidney disease
 Procházková, Jana ; Vlček, Jiří (advisor) ; Doseděl, Martin (referee)
Candidate: Jana Procházková1 Supervisor: prof. RNDr. Jiří Vlček, CSc.1 Consultant: PharmDr. Zuzana Očovská1 Title of the master thesis: Analysis of drug dosage adjustments in patients with chronic kidney disease 1 Department Social and Clinical Pharmacy, Faculty of Pharmacy in Hradec Králové, Charles University Several medications excreted by the kidneys or associated with an increased risk for adverse drug events in patient with chronic kidney disease (CKD) require dosage adjustment, cautious use or avoidance. However, a number of studies show that appropriate dosage adjustment is not provided in many cases. Our objective was to analyze appropriateness of drug dosages and contraindicated medications in patients with CKD admitted to the hospital in Hradec Králové via the department of emergency medicine. This study is an observational cross-sectional study and represents a sub-study of the previous study that examined drug-relatedness of unplanned hospital admissions to University Hospital Hradec Králové in 2018. The data were obtained from electronic medical records. The appropriateness of drug use and drug dosages was analyzed in patients with an estimated glomerular filtration rate (eGFR) between 15 and 60 mL/min/1.73 m2 based on comparison with the Summary of Product Characteristics (SmPC). The...
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