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Determination of flowable liquid retention potential of Aeroperl® for three hydrophilic solvents
Macharová, Květa ; Vraníková, Barbora (advisor) ; Školová, Barbora (referee)
Charles University in Prague, Faculty of Pharmacy in Hradec Králové Department of: Pharmaceutical Technology Candidate: Květa Macharová Supervisor: PharmDr. Barbora Vraníková, Ph.D. Title of Diploma Thesis: Determination of flowable liquid retention potential of Aeroperl ® for three hydrophilic solvents Preparation of modern dosage form called liquisolid systems may lead to the increased bioavailability of poorly water-soluble drugs. The main principle of their preparation is conversion of the drug in the liquid form to a dry non-adhesive powder with properties suitable for further processing. However, each powder is able to retain only a certain amount of liquid while maintaining appropriate flow properties and compressibility. The objective of this diploma thesis was to determine the flowable liquid retention potential of Aeroperl® 300 for three non-volatile solvents (polyethylene glycol 200 and 400 and propylene glycol). The value of flowable retention potential of Aeroperl® 300 was established to 0.5, 0.44 and 0.36 for propylene glycol, polyethylene glycol 400 and polyethylene glycol 200, respectively.
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Clay minerals as drug stabilizers
Markytánová, Petra ; Rabišková, Miloslava (advisor) ; Vraníková, Barbora (referee)
Charles University in Prague, Faculty of Pharmacy in Hradec Králové Department of: Farmaceutické technologie Consultant: prof. PharmDr. Miloslava Rabišková, CSc. Student: Petra Markytánová Title of Thesis: Clay minerals as drug stabilizers This thesis presents clay minerals as drug stabilizers. The aim of thesis was introduction of phyllosilicates, kaolinite, talc, smectites and fibrous clays which belong to the most important minerals. These clays are widely used as active substances or excipients in the formulation of dosage forms such as solid, liquid or semisolid. The structure, classification and useful properties directly related to their colloidal size and structure are shortly disscussed. Clay minerals posses excellent properties such as high adsorption capacity, swellability, low or null toxicity, good biokompatibility and promise for controlled release, thus give rise to the incess and interest to their development for biological purposes. The important chapter are current challenges in pharmaceutical applications. Besides classic pharmaceutical uses, clay minerals may be effectively used in formulations for controlled drug delivery systems. A very interesting possibility is to use clay minerals polymer composites, that can be used to prepare the nanoparticles, films, hydrogels or...
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The effect of the drying temperature on the properties of spray-dried lactose
Slezáčková, Jana ; Svačinová, Petra (advisor) ; Vraníková, Barbora (referee)
Charles University, Faculty of Pharmacy in Hradec Králové Department of: Pharmaceutical Technology Consultant: PharmDr. Petra Svačinová, Ph.D. Student: Jana Slezáčková Title of Thesis: The effect of the drying temperature on the properties of spray-dried lactose The aim of this work was to investigate the effect of inlet temperature on the physicochemical properties of spray dried lactose. 10% lactose solution was prepared by dissolving D-lactose monohydrate in distilled water and subsequently dried in a laboratory-scale spray drier. The inlet temperature of 130 řC - 200 řC was used. The physicochemical properties of lactose particles was investigated by optical microscopy and differential scanning calorimetry. Results indicated the influence of inlet temperature on particle size and shape and thermal properties of dried material. The morphology of spray-dried lactose showed tendency to higher sphericity when higher temperatures in a spray-drying process were used. Most of particles was in range 2,5 - 7,5 μm. The particles larger than 20 μm wasn't observed at the inlet temperature of 150 - 200 řC. At the inlet temperature over 150 řC the glass transition temperature was noticed. The glass transition temperature was observed around 24,8 - 63,5 řC. It was evident that higher drying temperature...
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The utilization of the surface tension measurement for the evaluation of critical micelle concentration of cationic surfactants
Oláhová, Kristýna ; Vraníková, Barbora (advisor) ; Šklubalová, Zdeňka (referee)
Charles University, Faculty of Pharmacy in Hradec Králové Department of: Pharmaceutical Technology Consultant: PharmDr. Barbora Vraníková, Ph.D. Student: Oláhová Kristýna Title of Thesis: The utilization of the surface tension measurement for the evaluation of critical micelle concentration of cationic surfactants The theoretical part of this diploma thesis gives an overview of surfactants properties and their classification based on the ability to dissociate and value of hydrophilic-lipophilic balance. This thesis also describes methods used to determinate critical micelle concentration such as surface tension or molar conductivity measurements, and factors that can affect it. The experimental part deals with the evaluation of the critical micelle concentration of the new synthesized cationic surfactant (ILA-3) that has a potential use as a chiral selector in capillary electrophoresis. The surface tension measurement by du Noüy ring metod was used to determinate critical micelle concentration. The value of this concentration was measured in ultrapure water and acetate buffer of pH 5.5. The obtained values of critical micelle concentration of ILA-3 were established to 118.37 mg/l (0.32 mM) and 12.73 mg/l (0.04 mM) for ultrapure water and acetate buffer, respectively. For comparison, the critical...
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Study of consolidation behaviour of lactose and its blends
Bérešová, Michaela ; Šklubalová, Zdeňka (advisor) ; Vraníková, Barbora (referee)
Charles University in Prague, Faculty of Pharmacy in Hradec Králové Department of: Pharmaceutical Technology Consultant: doc. PharmDr. Zdeňka Šklubalová, Ph.D. Student: Michaela Bérešová Title of Thesis: Study of consolidation behaviour of lactose and its blends Flow behaviour and consolidation properties are important characteristics of the powder substances. The aim of this thesis was to evaluate these properties for four types of lactose with different particle size and for the mixtures of two lactoses with different flow properties. The density and porosity of the powder bed and their changes during the consolidation due to the gravitational tapping were studied. The non-linear regression equation was used to describe the consolidation process for the samples and the parameter N½, which expresses the number of taps needed to achieve a half reduction of a powder bed volume. The value of N½ increased with the decrease in the particle size.
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The influence of the dwell time on the parameters of the stress relaxation test for microcrystalline cellulose and starch.
Hamplová, Kateřina ; Svačinová, Petra (advisor) ; Vraníková, Barbora (referee)
Charles University in Prague, Faculty of Pharmacy in Hradec Králové Department of: Pharmaceutical technology Consultant: Mgr. Svačinová Petra, Ph.D. Student: Hamplová Kateřina Title of Thesis: The influence of the dwell time on the parameters of the stress relaxation test for microcrystalline cellulose and starch. This thesis is focused on the viscoelastic properties of pharmaceutical excipients and the tensile strength of tablets. The theoretical part describes used materials. Microcrystalline cellulose and starch were used as fillers and magnesium stearate at concentration of 1% was used as lubricant. The stress relaxation test and its evaluation and utilization not only in pharmacy is described as well as the tensile strength of tablets. The experimental part deals with the viscoelastic properties of used materials and their mixtures with lubricant. These properties were evaluated using the stress relaxation test. At maximum compression force of 10 kN the length of dwell time was changed (60 s, 120 s, 180 s, 240 s, 300 s, 360 s, 420 s, 480 s, 540 s, 600 s). For derived parameters of elasticity A1-3 and plasticity P1-3 the dependence on the length of dwell time was evaluated. Parameter A1 increases with increasing dwell time for all substances. For parameters A2, A3, the dependence on the dwell...
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Fractal aspects of sorbitol flow.
Dvořáková, Klára ; Šklubalová, Zdeňka (advisor) ; Vraníková, Barbora (referee)
The size and shape of bulk solid particles is an important factor which affects its flow and consolidation behaviour. In this thesis, the properties of sorbitol size fractions ranging from 80 to 500 µm were studied by using helium pycnometry, optical microscopy and changes in the volume of the powder bed during the initial phase of consolidation. A significant influence (p ≤ 0.01) of the sample drying on the density of solid sorbitol was detected. Porosity of sorbitol size fractions ranged from 56.6 to 62.3%; with the increasing in the particle size the porosity decreased. For the consolidation of the powder bed, the first 10 taps were critical when the volume decreased most dramatically. This is particularly evident for the size fraction of 100 µm and 158 µm.
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Study of skin barrier defects by lipid monolayers
Nováčková, Anna ; Školová, Barbora (advisor) ; Vraníková, Barbora (referee)
Charles University in Prague, Faculty of Pharmacy in Hradec Králové Department of Pharmaceutical Technology Author: Anna Nováčková Supervisor: Mgr. Barbora Školová, Ph.D. Title of thesis: Study of skin barrier defects by lipid monolayers Ceramides (Cer) together with free fatty acids and cholesterol form the intercellular space of the uppermost skin layer, the stratum corneum (SC). This lipid matrix presents the skin barrier, which protects human organism from environmental factors (endogenous substances, physical radiation) as well as prevents the body from water loss. Cer are synthetized from polar precursors: glucosylated Cer (GCer) and sphingomyelins by splitting the polar part by the hydrolytic enzymes β-glucocerebrosidase (β-GCer-ase) and sphingomyelinase. A lack of these enzymes leads to accumulation of precursors and a non-functional skin barrier is formed. The goal of this work was to study the β-GCer-ase defects by monolayer lipid models of the SC. The impact of GCer quantity on lipids organisation was evaluated by several techniques (Langmuir monolayers at the gas-liquid interface, Brewster angle microscopy and atomic force microscopy). At the gas - liquid interface mixtures with precursor do not organise spontaneously at lower surface pressures (1.5 mN/m). However, with increasing...
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Dosage forms in therapy of posterior segments of the eye
Pospěchová, Lucie ; Šklubalová, Zdeňka (advisor) ; Vraníková, Barbora (referee)
1 Abstract Charles University in Prague, Faculty of Pharmacy in Hradci Králové Department of: Pharmaceutical Technology Consultant: doc. PharmDr. Zdeňka Šklubalová, Ph.D. Student: Lucie Pospěchová Title of Thesis: Dosage forms in therapy of posterior segments of the eye. Therapy of the posterior eye segments is very difficult. Because most of diseases of the posterior eye segments could lead to complete blindness, the research of dosage forms for the drug delivery into this eye part is intensively developing at this moment. The aim of this thesis is to provide a review of anatomical and physiological specifics of both- anterior and posterior segments of the eye. The most common diseases of the posterior eye are referred to, for example the age related macular degeneration and/or the cytomegalovirus retinitis. There are various routes of application and drug dosage forms that are used for the therapy and which are mentioned in this work, including the drug delivery and targeting systems.
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Evaluation of the properties of granules and tablets prepared from starch
Skořepová, Zuzana ; Šklubalová, Zdeňka (advisor) ; Vraníková, Barbora (referee)
Charles University, Faculty of Pharmacy in Hradec Králové Department of: Pharmaceutical Technology Consultant: Doc. PharmDr. Zdeňka Šklubalová, Ph.D. Student: Mgr. Zuzana Skořepová Title of Thesis: Evaluation of the properties of granules and tablets prepared from starch In this thesis, the flow properties of granules prepared from potato and/or corn starch respectively, using two types of disintegrants (croscarmellose or sodium starch glycolate) by fluid bed granulation were studied. The particle size distribution, the bulk and tapped density and flow rate of granules and their porosity by gas pycnometer were determined. After the addition of magnesium stearate (0,5 %) the tablets were compressed and their strength and disintegration time were evaluated. The significant effect of type of starch and disintegrants for the disintegration time was proved (p ≤ 0,01); the strength of tablets was significantly (p ≤ 0,01) influenced by only type of disintegrant. The best bulk properties and the shortest disintegration time were observed for the granules made from potato starch in combination with croscarmellose.
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