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Gliadin fragments induce phenotypic and functional maturation of human dendritic cells
Palová-Jelínková, Lenka ; Rožková, D. ; Pecharová, Barbara ; Bártová, J. ; Šedivá, A. ; Tlaskalová, Helena ; Spíšek, R. ; Tučková, Ludmila
Gliadin treatment also resulted in increased NF- B/DNA binding activity of p50 and p65 subunits. Taken together, gliadin peptides can contribute to overcoming the stage of unresponsiveness of immature DC by inducing phenotypic and functional DC maturation, resulting in more efficient processing and presentation of gliadin peptides to specific T lymphocytes
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The response of peripheral blood monocytes from celiac patients to gliadin peptides
Cinová, Jana ; Palová-Jelínková, Lenka ; Smythies, L. ; Černá, M. ; Pecharová, Barbara ; Dvořák, M. ; Fruhauf, P. ; Tlaskalová, Helena ; Smith, P. ; Tučková, Ludmila
We documented that gliadin digest stimulate PBMoC (isolated from celiac patients and healthydonors) to IL-8 and TNF alfa production through the NF-kappa B pathway. Monocytes expressed increased levels of dendritic cell markers
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Slizniční imunita, střevní mikroflora a nespecifické střevní záněty
Tlaskalová, Helena ; Štěpánková, Renata ; Sokol, Dan ; Rossmann, Pavel ; Cukrowska, Božena ; Hudcovic, Tomáš ; Tučková, Ludmila ; Kozáková, Hana ; Řeháková, Zuzana ; Hrnčíř, Tomáš ; Drastich, Pavel ; Frolová, Lenka ; Powrie, F. ; Uhlig, H. ; Bland, P. W.
Etiological role of intestinal microflora and abberant function of mucosal immunity in development of inflammatory bowel disease is discussed. Animal models of human IBD are described and characterized
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Mucosal immunity, intestinal microflora and inflammatory bowel disease (IBD)
Tlaskalová, Helena ; Štěpánková, Renata ; Powrie, F. ; Tučková, Ludmila ; Sokol, Dan ; Funda, David P. ; Rossmann, Pavel ; Cukrowska, Božena ; Hudcovic, Tomáš ; Kozáková, Hana ; Řeháková, Zuzana ; Hrnčíř, Tomáš ; Drastik, p. ; Smetana, K. ; Frolová, Lenka
The interface between the organism and the outside world, which is the site of exchange of nutrients.
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