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New Membranes with Immobilizing Chiral Selector for Racemic Micture Separation.
Gaálová, Jana ; Cuřínová, Petra ; Stibor, Ivan ; Izák, Pavel
Enantiomers exhibit identical properties in the achiral environment, however, they often differ in effectiveness, pharmacological activity and pharmacokinetic profile since the modules with which they interact in biological systems are also optically active [1,2]. Racemic immobilizing chiral selector is present. Five types of membranes with different amount of chiral selector were used. During the pertraction experiments the membranes were subsequently placed between the feed and receiving phase of the pertraction cell. During pertraction experiments we find out, that kinetics of the pertraction significantly influence the enantiomer resolution what indicated that facilitated transport is employed; while enantioselective sorption activity of the membranes reached up to 100%.
Fulltext: content.csg -  PDF
Plný tet: SKMBT_C22018060513580 - PDF
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Synthesis of biaryl oxa- and aza-macrocycles
Koščová, Simona ; Hodačová, Jana (advisor) ; Jindřich, Jindřich (referee) ; Macháček, Vladimír (referee) ; Stibor, Ivan (referee)
The Thesis deals with the synthesis of oxa- and aza-maclocycles, in which the basic structttlal unit comprises of the axially chiraÍ bipherryl or l,1..binaphthyl platform. These ligands can exhibit interesting properties in a field of molecular recognition. Crown ethers and their heteroatom analogues are known as exce|lent receptors Íbr conrplexation oť cations, anions or nentral molccules. Aza-macrocycles of the bíphenyl type 1.4 have becn prepared by reductiorr of amicle's 9-12' Although the prrriÍication of polyamines constitutes generally a difficrrlt problcm, the compouncls 1-4 have been ftrlly characterised: tlie compounds 1-3 as hydrobromicles, ancl the cottrpottncl 4 in the ťorrn oťperchloratg' ,Ithe X-ray crystal stťtlctLtlc analysis of, tetrahydrobromide 2 has revealed interesting infoimation about its stnrcture, Lígancl 2 bincls two brornide attions, one aniotr is helcl abovc the plarre of the macrocyclic cavity ancl the seconcl one bclow it. Amino-lactarns 9-12 r'epresent attractive structnres in the area of cupric salts complexation, Despite the structures of ligancls 9 and 10 are similar to each othu, their complexation behaviour is conrpletely different. The ligand 9 í.orms in one step ner'ttral complex [Cu'9.H.zJ with copper at pH about 7, showirrg thrrs excellent preťequisite for...
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Reaction of prion protein with quinacrine
Zawada, Zbigniew ; Šafařík, Martin ; Šebestík, Jaroslav ; Stibor, Ivan ; Bouř, Petr
Prion protein is supposed to cause Creutzfeld–Jakob disease, which can be treated in cell culture by quinacrine. In this work we study acridinylation reaction of prion protein. We also investigate this reaction theoretically on simple models and calculate activation energies for a large ensemble of acridine derivatives. Found correlation between the reactivity and geometry can enhance the design of the new acridine compounds, particularly for medical purposes.
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