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Assesment of diagnostic methods for immunologically based skin diseases
Brodská, Petra ; Pizinger, Karel (advisor) ; Arenberger, Petr (referee) ; Skořepová, Magdalena (referee)
Background: Atopic dermatitis is a common chronic inflammatory skin disease. Numerous IgE-inducing allergens play role in the pathogenesis of atopic dermatitis. Malassezia, the predominant skin microbiota fungus, is considered to exacerbate atopic dermatitis, especially in a subset of patients with head and neck type. In the present study the relationship between atopic dermatitis and sensitization to Malassezia antigens was investigated. Methods: We assessed 240 patients with atopic dermatitis seen at the Department of Dermatology, University Hospital in Zürich, Switzerland and at the Department of Dermatovenereology, University Hospital in Pilsen, Czech Republic. The subgroup of patients with primarily head, neck and upper torso pattern of atopic dermatitis was considered as HNAD type. Severity of eczema was assessed with EASI in Switzerland and with SCORAD in the Czech Republic. Total serum IgE and specific IgE to Malassezia were determined and correlated with clinical picture of atopic dermatitis, gender, age and severity of eczema. Results: Total IgE was elevated in 72.5% of patients. Specific IgE to Malassezia was positive (≥ 0.35 kU/l) in 54.2% of patients. Men were significantly more often sensitized to Malassezia antigen (63.5% of men versus 47.1% of women, p-value 0.013). Concurrently, patients...
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Assesment of diagnostic methods for immunologically based skin diseases
Brodská, Petra ; Pizinger, Karel (advisor) ; Arenberger, Petr (referee) ; Skořepová, Magdalena (referee)
Background: Atopic dermatitis is a common chronic inflammatory skin disease. Numerous IgE-inducing allergens play role in the pathogenesis of atopic dermatitis. Malassezia, the predominant skin microbiota fungus, is considered to exacerbate atopic dermatitis, especially in a subset of patients with head and neck type. In the present study the relationship between atopic dermatitis and sensitization to Malassezia antigens was investigated. Methods: We assessed 240 patients with atopic dermatitis seen at the Department of Dermatology, University Hospital in Zürich, Switzerland and at the Department of Dermatovenereology, University Hospital in Pilsen, Czech Republic. The subgroup of patients with primarily head, neck and upper torso pattern of atopic dermatitis was considered as HNAD type. Severity of eczema was assessed with EASI in Switzerland and with SCORAD in the Czech Republic. Total serum IgE and specific IgE to Malassezia were determined and correlated with clinical picture of atopic dermatitis, gender, age and severity of eczema. Results: Total IgE was elevated in 72.5% of patients. Specific IgE to Malassezia was positive (≥ 0.35 kU/l) in 54.2% of patients. Men were significantly more often sensitized to Malassezia antigen (63.5% of men versus 47.1% of women, p-value 0.013). Concurrently, patients...
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The attitude towards prevention and long-term follow-up in patients diagnosed with melanoma
Konkoľová, Radmila ; Provazníková, Hana (advisor) ; Janout, Vladimír (referee) ; Skořepová, Magdalena (referee)
52 7.2 Souhrn v anglickém jazyce Malignant melanoma is the most lethal skin cancer whose incidence has been worldwide increasing. The prognosis of the disease is dependent on many factors - the effected locality, age, form of the tumor and the growth stage at which it was surgically removed. There has been no reliable adjuvant treatment available so far; although cytokins have been recently administered to high-risk patients. The accent is therefore put mainly on the timely detection and the relevant extent of surgical intervention whose degree depends on the stage of the disease. The result of the above mentioned facts is the necessity of an early diagnosis of new cases and permanent follow-up of the patients in whom melanoma has been already confirmed. The patients in the follow-up care are regularly checked, for the rest of their lives, at by the so called melanoma commissions, usually at dermatological clinics. The permanent contact with fact of the possible presence of the disease (information about the diagnosis, repeated follow-ups, waiting for the results of the examination) is stressful for these patients, although they become, to a certain extent, gradually adapted to stress. A good adaptation is however dependent also on the extent of social support, depression, the severity of the disease and...
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