National Repository of Grey Literature 2 records found  Search took 0.01 seconds. 
Synthesis of Chromenopyridines with the New All-Carbon Quaternary Centre
Sedláček, Patrik ; Matouš, Petr (advisor) ; Krátký, Martin (referee)
Charles University in Prague Faculty of Pharmacy in Hradec Králové Candidate: Patrik Sedláček Supervisor: PharmDr. Petr Matouš, Ph.D. Title of thesis: Synthesis of Chromeno[3,4-c]pyridines with New All-Carbon Quaternary Centre This diploma thesis focuses on the synthesis of 3,4-disubstituted pyridine derivatives and their subsequent cyclization to form chromeno[3,4-c]pyridine derivatives with a new all-carbon quaternary center. Phenyl-propiolate reacts with an aryl-substituted propargyl amine protected with 4- methoxybenzenesulfonyl group to form a 1,5-enyne. Substituted 1,5-enyne undergoes intramolecular cyclization catalyzed by tri(2-furyl)phosphinogold(I)chloride [AuCl(TFP)] to form the corresponding dihydropyridine. In the presenece of concentrated H2SO4, dihydropyridine undergoes carbocyclization forming the corresponding chromenopyridine with a new all-carbon quaternary center. The compounds prepared and their derivatives could find application as potentially biologically active substances and intermediates in organic synthesis.
The Proposal of Lean Manufacturing Products with the Use Kaizen
Vlk, Jaroslav ; Sedláček, Patrik (referee) ; Jurová, Marie (advisor)
This diploma thesis is focused to the design of the system of improvement proposals for the application of Lean Production in the selected company. For this purpose, there is a description of the company and its current condition and there are also presented theoretical bases and the design of the system according to the requirements and possibilities of the company.

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4 Sedláček, Pavel
45 Sedláček, Petr
2 Sedláček, Petr,
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