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Rheological properties of agar-based gels for ultrasound brain phantom
Schneiderová, Marie ; Šnejdrová, Eva (advisor) ; Holas, Ondřej (referee)
CHARLES UNIVERSITY FACULTY OF PHARMACY IN HRADEC KRÁLOVÉ DEPARTMENT OF PHARMACEUTICAL TECHNOLOGY Author: Marie Schneiderová Supervisor: Phar Dr Eva nejdrová Ph D Title of diploma thesis: Rheological properties of agar-based gels for ultrasound brain phantom The diploma thesis deals with the evaluation of the rheological properties of agar gels on a rotational rheometer. The theoretical section contains the characterization of gels, their distribution, properties and use in pharmacy, describes agar and its characteristic properties. It also provides brief information on phantoms and describes the agar-based phantom in more detail. The principles of oscillation tests and their evaluation are described. Twelve gels with different agar concentrations were tested: a series of gels without glycerol and a series of gels with glycerol. The structure of the gels was characterized by the test Evaluating product texture using oscillatory testing and te perature stability in the range of 20 ř C to 40 ř C by the Single frequency strain controlled temperature ramp test. The viscoelastic properties of pig brain tissue were characterized by the same tests. The gel structure was confirmed in all samples tested. The stiffness expressed by the value of the complex modulus G * increases with the agar concentration....

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