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Evaluation of the interlaboratory variability of exaqmination of receptor markers of the breast cancer
Pešinová, Šárka ; Hochmann, Jiří (advisor) ; Doležel, Martin (referee)
Charles Univerzity in Prague Faculty of Pharmacy in Hradec Králové Department of Biological Sciences Candidate: Bc. Šárka Pešinová Supervisor: MUDr. Jiří Hochman, CSc. Title of diploma thesis: Evaluation of the interlaboratory variability of exaqmination of receptor markers of the breast cancer In this diploma thesis, we are focused on the question of the breast cancer. We chose the bioanalitical access to estrogens and progesterone receptors (ER and PR). These receptors are important for deciding of treatment method. We divided a practice part to two partitions. In the first one, we try to consider statistically a sensitivity of the methods of the diferent laboratories. In the sekond one we comparted the processed records from the hospital Pardubice. In terms of practical part, ER and PR data from diferent scientific intrnational literature were processed and categorized. We were focused to the diference of the amount of patiens, the number of ER (+) and PR (+), on the year of study. In several cases we found even the statistical increasing of ER investigation sensitivity - on the basis of the increasing amount of positive patient. Our other aim was to compare the statistical results of Pardubice imunohistochemical laboratories in by us constructed graphs in term of positivity boundary. We also...
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Evaluation of the interlaboratory variability of exaqmination of receptor markers of the breast cancer
Pešinová, Šárka ; Doležel, Martin (referee) ; Hochmann, Jiří (advisor)
Charles Univerzity in Prague Faculty of Pharmacy in Hradec Králové Department of Biological Sciences Candidate: Bc. Šárka Pešinová Supervisor: MUDr. Jiří Hochman, CSc. Title of diploma thesis: Evaluation of the interlaboratory variability of exaqmination of receptor markers of the breast cancer In this diploma thesis, we are focused on the question of the breast cancer. We chose the bioanalitical access to estrogens and progesterone receptors (ER and PR). These receptors are important for deciding of treatment method. We divided a practice part to two partitions. In the first one, we try to consider statistically a sensitivity of the methods of the diferent laboratories. In the sekond one we comparted the processed records from the hospital Pardubice. In terms of practical part, ER and PR data from diferent scientific intrnational literature were processed and categorized. We were focused to the diference of the amount of patiens, the number of ER (+) and PR (+), on the year of study. In several cases we found even the statistical increasing of ER investigation sensitivity - on the basis of the increasing amount of positive patient. Our other aim was to compare the statistical results of Pardubice imunohistochemical laboratories in by us constructed graphs in term of positivity boundary. We also...
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