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Effect of paracetamol on the parameters of compression equation
Mařanová, Lucie ; Řehula, Milan (advisor) ; Ondrejček, Pavel (referee)
Evaluation of the tableting mixtures containing the paracetamolum by the parameters of the equation of compression The diploma thesis deals with effect of paracetamol on the parameters of compression equation. These parameters characterize compression process in the individual phases of compression: precompression phase, phase of elastic deformation and phase of plastic deformation. Paracetamolum was studied in the five mixtures, where it occurred in different ratio with microcrystalline cellulose. Looseness, Carr's index and Hausner ratio were evaluated for each mixture. The sizes of reductions ai, sizes of energies Ei and Ri, "half-pressures" pHi and the velocity constants 1/ti were calculated using three-exponential equation of compression for the individual phases of pressing. The results showed poor flow properties of tableting mixtures and thus its unsuitability for direct compression. The results of the study have revealed that increasing amounts of paracetamolum in the mixture increase reduction of volume a1 and velocity of volume change 1/t1 in dependence on the amount of the extruded air and decrease the required energy due to the smooth surface and less friction during the precompression phase. Reduction of volume a2 decrease with the increase of content of paracetamol due to...
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Effect of acetylsalicylic acid on the parameters of compression equation
Šmíd, Jakub ; Řehula, Milan (advisor) ; Ondrejček, Pavel (referee)
Charles University in Prague, Faculty of Pharmacy in Hradec Králové Department of Pharmaceutical Technology Student: Jakub Šmíd Consultant: Doc. RNDr. Milan Řehula, CSc. Effect of acetylsalicylic acid on the parameters of compression equation Compacting process can be expressed mathematically by compression equations. It is characterized by various parameters. The compression equation expresses the dependence of the volume, density and height on compacting pressure. This paper evaluates the parameters of the compaction equation and study pre-loading phase, the phase of elastic deformation and the phase of plastic deformation. This thesis examines effect of acetylsalicylic acid on the parameters of compaction equation. Tablets were compressed from five mixtures. Mixtures contained acetylsalicylic acid and microcrystalline cellulose in different ratios 0:100, 25:75, 50:50, 75:25 and 0:100. The results were obtained using the three-exponential equation. Evaluation was carried out by using box plots.
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Effect of ibuprofen on the parameters of compression equation
Tisoňová, Zuzana ; Řehula, Milan (advisor) ; Ondrejček, Pavel (referee)
Charles University in Prague, Faculty of Pharmacy in Hradec Králové Department of Pharmaceutical Technology Student: Tisoňová Zuzana Consultant: Doc. RNDr. Milan Řehula, CSc. Compacting process is mathematically expressed by compression equations. It is characterized by various parameters of equations. The equation expresses the dependence of the volume, density and height on compacting pressure. In this paperwork, the parameters of compacting equation are evaluated and the pre-loading phase, the phase of elastic deformation and the phase of plastic deformation are studied. This thesis deals with impact of ibuprofen on the parameters of compaction equation. Five mixtures which included microcrystalline celulose and ibuprofen in different ratio 100:0, 75:25, 50:50, 25:75 and 0:100 were studied. Results were based on the three-exponential equation. They were evaluated thanks to box plots. From the results obtained, it is obvious that with decreasing amount of microcrystalline cellulose, the parameter a1 has increased and the parameter E1 also slightly has increased. The composition of the used material didn't have any huge influence on parameters 1/t1 and pH1. During the phase of elastic deformation, the parameters a2 and E2 with decreasing amount of ibuprofen have decreased. On the other hand, the...
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Effect of ascorbic acid on the parameters of compression equation
Pribylincová, Natália ; Řehula, Milan (advisor) ; Ondrejček, Pavel (referee)
Charles University in Prague, Faculty of Pharmacy in Hradec Králové Department of Pharmaceutical Technology Student: Natália Pribylincová Consultant: Doc. RNDr. Milan Řehula, CSc. Effect of ascorbic acid on the parameters of compression equation Many mathematical models describing the compressing process are widely used in the development of new medicinal products in form of tablets. This process can be evaluated by means of compaction equations or throughout the viscoelastic properties. Compaction equation expresses dependency on height, volume or density of the used material which is being compressed by the applied compacting pressure. Based on the gained parameters, it is possible to describe specifically various stages of the compaction process, to determine characteristic properties of the studied material and accordingly to examine its mechanism. This thesis deals with the impact of the ascorbic acid on the parameters of compaction equation. The paperwork evaluates a mixture consisting of ascorbic acid (AA) and microcrystalline cellulose (MCC) in the ratio of MCC : AA 100:0, 75:25, 50:50, 25:75, 0:100. . The mostly used compression equations are described in the theoretic part. The three - exponential equation by Řehula created at the Department of Pharmaceutical Technology at Charles...
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Liquid paediatric preparations 1. Sotalol hydrochloride.
Kříž, Tomáš ; Šklubalová, Zdeňka (advisor) ; Ondrejček, Pavel (referee)
Charles University in Prague, Faculty of Pharmacy in Hradec Králové Department of: Pharmaceutical Technology Consultant: Doc. PharmDr. Zdenka Šklubalová, Ph.D. Student: Tomáš Kříž Title of Thesis: Liquid paediatric preparations 1. Sotalol hydrochloride The aim of this work was to formulate suitable paediatric oral solution with sotalol hydrochloride 5 mg/ml using a minimum amount of excipients. After the preformulation study, eight aqueous solutions of sotalol hydrochloride were compounded using citric acid and dibasis sodium phosphate dodecahydrate to stabilize pH value, potassium sorbate as a preservative, and simple sucrose syrup and/or sodium saccharin, respectively, as sweeteners. Density and osmolality of the formulations were estimated. The solutions were stored at two different temperatures of 2-8 řC and/or 2-8 řC, respectively, and the pH values were measured during 90 days. All studied formulations showed stable pH values at both temperatures of storage, except for an aqueous sotalol hydrochloride solution. Some of the formulations were proposed for validated stability study with a determination of the concentration of sotalol hydrochloride and potassium sorbate using HPLC.
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A study of the compressibility and properties of tablets from co-processed dry binder composed of microcrystalline cellulose and glyceryl monostearate.
Muchová, Sandra ; Mužíková, Jitka (advisor) ; Ondrejček, Pavel (referee)
The paper studies the co-processed dry binder LubriTose™ MCC from the viewpoint of energy evaluation of the compression process, strength and disintegration time of tablets. The results were compared with the identical evaluation of physical mixtures of microcrystalline cellulose with several types of lubricants. LubriTose™ MCC showed the lowest value of energy for friction, the highest value of energy accumulated by the tablet, and the highest plasticity of all tableting materials under study. There were no marked differences in the values of the energy of decompression. The tensile strength of tablets from LubriTose™ MCC was lower than in those from the mixture of Vivapur® 12 and glycerol monostearate, in the compression forces of 4 and 5 kN it was comparable with the tensile strength of tablets from Vivapur® 12 with poloxamer 407. Disintegration time of tablets from LubriTose™ MCC was shorter than that of those from Vivapur® 12 with glycerol monostearate at the compression force of 3 kN, in the case of the compression forces of 4 and 5 kN no statistically significant difference was found between the values of these tableting materials.
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A study of the compaction process and the properties of tablets made of agglomerated and granulated lactose
Neprašová, Marie ; Mužíková, Jitka (advisor) ; Ondrejček, Pavel (referee)
The thesis studied tensile strength, disintegration time of tablets and energy profile of compression of agglomerated lactose Tablettose® 80 and of granulated lactose SuperTab® 30GR. Tested parameters were studied depending on compression force, addition of two concentrations of the lubricant magnesium stearate (0.5 and 1%) and 25% microcrystalline cellulose Microcel® MC-200. The tablets were compressed using the material testing machine T1 - FRO 50 TH.A1K Zwick/Roell. Used compression forces were 11, 13 and 15 kN, in the case of mixtures with Microcel® MC-200 11 kN. Tensile strength of tablets increased with compression force at both lactoses and it was higher in the case of mixtures with SuperTab® 30GR. Magnesium stearate decreased the tensile strength of tablets from Tablettose® 80 for all compression forces. Addition Microcel® MC-200 increased the tensile strength of tablets from both lactoses, more in the case of Tablettose® 80. Disintegration time of tablets increased with compression force. Higher concentrations of magnesium stearate in tablets increased disintegration time. Comparison of disintegration time of tablets from both lactoses depended on concentration of magnesium stearate. Addition of Microcel® MC-200 significantly shortened disintegration time of tablets in both lactoses. The...
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Compressibility of different batches of the drug Simvastatin.
Havelková, Adéla ; Řehula, Milan (advisor) ; Ondrejček, Pavel (referee)
This thesis deals with the characterization of pressing energy using the force-displacement diagram. The theoretical part defines the substance - simvastatin - and excipients which could occur in unknown samples. Also energies of pressing process, methods of assessment of force-displacement diagram for different substances and factors which affect pressability and thus the pressing energy are described there. The aim of the experimental part of the thesis was to characterize the energy profile using force-displacement diagram of eight batches of preparation simvastatin and to find applicable method of assessment. Tablets were pressed from each batch of preparations using a T1-FRO 50 machine at three pressing forces 5, 10, and 15 kN. Obtained parameters E2, E3, Elis and Pl were evaluated using three methods: method of outlying values, method of analysis of average for one factor and method of analysis of average for two factors. The most suitable method for assessment of divergent values is the method of analysis of average for two factors thanks to its complex character. This method showed lower values of the parameters E1, E2, Elis and Pl for batches E, G and H which could be caused by larger particles and higher moisture of granulate.
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Properties and the employment of parenteral preprations.
Kotásková, Denisa ; Šklubalová, Zdeňka (advisor) ; Ondrejček, Pavel (referee)
Charles University in Prague, Faculty of Pharmacy in Hradci Králové Department of: Pharmaceutical Technology Consultant: Doc. PharmDr. Šklubalová Zdeňka, Ph.D. Student: Denisa Kotásková Title of Thesis: Properties and the employment of parenteral preparations. This thesis presents parenteral preparations. The aim of thesis was introduction of injection and infusion preparations, which are the most commonly used parenteral drug forms. The emphasis is placed on the complete list of excipients which are essential ingredients because they ensure the safety and efficacy of this formulation and positively influence its properties. The essential pharmacopoeial quality requirements are shortly discussed, such as sterility, non-pyrogenity, the absence of particulate matter, nominal volume or airtight containers. The largest part of the thesis is focused on the use of the parenteral infusion. It deals primarily with the use of electrolyte solutions in the treatment of disorders of the inner body balance. The important chapter is the parenteral nutrition, which includes the most important nutrients such as carbohydrates, amino acids and microheterogenous oil emulsions. The peritoneal dialysis solution and the plasmaexpander solution are the supplement of this thesis. The thesis also attends to the production...
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Determining the compression behaviour of celluloses.
Ondrejček, Pavel ; Špaček, Vladimír (referee) ; Řehula, Milan (advisor)
Mechanical resistance of tablets is usually described by crushing force, or by tensile strength. Method used in this thesis records crushing force and path of crushing. This force-path record can be used to calculate crushing energy. Crushing force, crushing path and crushing energy can be used to calculate other parameters that characterize tablet properties. This thesis uses crushing force, volume crushing force, tensile strength, crushing energy, volume crushing energy and crushing energy related to tablet weight to describe tablets compressed of powdered cellulose, microcrystalline cellulose, hydroxypropylcellulose and lactose monohydrate. Results of this thesis shows descent of tensile strength in this order: microcrystalline cellulose Avicel PH-112, microcrystalline cellulose Avicel PH-101, hydroxypropylcellulose, powdered cellulose and lactose monohydrate. Kinetic characteristics of tablets descent in this order: hydroxypropylcellulose, microcrystalline cellulose Avicel PH-101, microcrystalline cellulose Avicel PH-112, powdered cellulose and lactose monohydrate.
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