National Repository of Grey Literature 270 records found  1 - 10nextend  jump to record: Search took 0.00 seconds. 
Serotonergic hallucinogenes and their therapeutic use
Bouberl, David ; Novotný, Jiří (advisor) ; Vejmola, Čestmír (referee)
Serotonergic hallucinogens are a group of substances that induce changes in consciousness based on their affinity for some of the serotonin receptors - especially 5-HT2A. The best known substances in this group include LSD, psilocybin or mescaline. During the 1950's and 1960's, initial research into the therapeutic uses of these substances took place, but studies from this period did not meet today's methodological standards. However, the results of recent studies point to the potential therapeutic use of psilocybin or LSD in the treatment of depression / anxiety, addiction and OCD. The aim of this work is to summarize current knowledge about selected serotonergic hallucinogens, their chemical properties, mechanisms of action and especially about the possibilities of using these substances in psychotherapy.
Involvement of cellular signal systems controlled by small G-proteins in neuroregenerative processes
Dušek, Jakub ; Novotný, Jiří (advisor) ; Košek, Dalibor (referee)
G-proteins repeatedly seem as significant signal mediators according to actual "cellular signal during neuroregeneration" reviews. This thesis aimed to find out how much small G-proteins correlate with neural tissue regeneration and which molecular mechanisms induce the regeneration. The thesis mentions pathologies of nervous system which are caused by traumas or neurodegenerative diseases in wider social perspective. Pivotal part of the text describes principles of functioning for each small GTPase family and its involvement in nervous tissue repair. This thesis demonstrates crucial role of small GTPases in neuroregeneration and points to considerable therapeutic potential of these GTPases. Key words: neuroregeneration; small GTPase; small G-protein; Ras; signal systems; neurodegeneration
Financial policy in times of crises until 19th century of the Bohemian Duchy
Novotný, Jiří ; Bažantová, Ilona (advisor) ; Dupáková, Lenka (referee)
Financial policy in times of crises until the 19th century Abstract This thesis focuses on financial policy during crises of the Bohemian Duchy, Kingdom of Bohemia, and Lands of the Bohemian Crown within The Austrian Empire until the 19th century. I will compare monetary and fiscal approaches to tackle the gravest crises caused by war, instability, or a financial breakdown. Therefore, in this thesis, I will analyse selected crises that took place in the Bohemian Duchy located in the Bohemian Kingdom at the end of the 13th century. I will focus on the Hussite wars, the great calada during the Thirty Years War, Napoleonic Wars, the Seven Years War, the Revolution of 1848, and the Long Depression, which started in 1873. The used methods are mainly comparison, analysis, and analogy. Results of the research indicate that an improper financial policy caused the majority of crises. Governmental approaches to solving fiscal, monetary and taxation problems were worsening the situation. Financial policy concerning monetary, fiscal, and tax policy until the end of the 19th century was procyclical. If enlightened politicians appeared in an era of prosperity, their plans for reforms were generally dashed by war and need for new governmental expenditures. However, the government, especially during the crisis, was prone...
Autophagy as a key mediator of beneficial effects of caloric restriction
Kačinská, Irena ; Novotný, Jiří (advisor) ; Funda, Jiří (referee)
Caloric restriction has long been known in the scientific world as a life-prolonging condition, and there is growing evidence that the effect of activation of non-selective autophagy is responsible for these effects. In this thesis, the molecular mechanisms of autophagy in the state of caloric restriction will be described, as well as its beneficial effects on the aging of the organism and various health problems associated with aging and the modern way of life will be summarized. Some risks that could result from unprofessional intervention in one's own body will also be mentioned. It is hypothesized that practicing caloric restriction under the supervision of an expert brings prevention of diseases of civilization diseases and diseases associated with aging and prolongs quality of life, which would, among other things, help reduce the cost of health and social care. Keywords: Autophagy, caloric restriciton, molecular mechanisms
Study of metabolic syndrome in mice model: roles of dietary lipids, adipose tissue and AMP-activated protein kinase
Medříková, Daša ; Kopecký, Jan (advisor) ; Houštěk, Josef (referee) ; Novotný, Jiří (referee)
Obesity and associated metabolic disorders, e. g. metabolic syndrome, represent a considerable health threat for modern society. Due to sedentary lifestyle, high caloric intake and changes in composition of diet, prevalence of obesity is increasing worldwide. One of the possible causes contributing to higher prevalence of obesity in recent population could be the change of fatty acids (FA) composition of dietary lipids, with the shift in the content of n-6 and n-3 FA toward n-6 FA. In contrast to n-6 FA, n-3 FA are known for their anti-atherogenic, anti-obesogenic and anti-inflammatory properties. In our experiments in mice, the capability of naturally occurred and chemically modified n- 3 long chain polyunsaturated fatty acids (LC-PUFA) in prevention and reversal of specific parts of metabolic syndrome was demonstrated. A specific chemical derivative of docosahexaenoic acid was proven to be very effective in preventing and improving metabolic conditions of animals exposed to high-fat (HF) diet challenge. Further, the involvement of AMP-activated protein kinase (AMPK), a master regulator of lipid metabolism, in skeletal muscle thermogenesis induced by HF-feeding was investigated. Activation of AMPK in the HF-fed mice is most possibly caused by increased leptin levels and represents an important link...
Analysis of results of particle phenomena modeling in computer games
Novotný, Jiří ; Boldyš, Jiří (advisor)
The main subject of this thesis is to design a method that is able to compare the outputs of a manually set up particle system with a video template of a simulated particle phenomenon. For the sake of simplicity, this work is focused exclusively to smoke effects and its comparisons. Specifically, descriptors depicting the color scheme of the examined input videos are proposed as well as the shape descriptors and time variability descriptors, which are based on the image segmentation method called Alpha Matting. This method is able to distinguish foreground objects from the background, while the foreground objects are described together with their transparency. Video template recordings captured specially for the purpose of this work are included. At the end, the resulting method is supported by an example of the gradually improving smoke effect simulation. Powered by TCPDF (
New analogs of anorexigenic neuropeptides involved in food intake regulation
Pražienková, Veronika ; Maletínská, Lenka (advisor) ; Novotný, Jiří (referee) ; Skálová, Lenka (referee)
This work focuses on anorexigenic neuropeptides, cocaine- and amphetamine-regulated transcript (CART) and prolactin-releasing peptide (PrRP), which decrease food intake and body weight. CART peptide is an anorexigenic neuropeptide and, despite many efforts, its receptor has not yet been identified. We found CART peptide specific binding sites in pheochromocytoma PC12 cells. Cells differentiated to neurons increased significantly the number of binding sites. On the other hand, after differentiation to chromaffin cells the number of binding sites was so low that it was impossible to determine their density. To clarify the importance of each of the three disulfide bridges in the CART molecule, analogs with one or two disulfide bridges were synthetized. The biological activity was maintained in analog with two disulfide bridges in positions 74-94 and 88-101. Moreover, we demonstrated the stimulation of JNK and subsequently c-Jun activation in PC12 cells. Neuropeptide PrRP belongs to the RF-amide peptide family and has anorexigenic properties. PrPR has a high affinity to GPR10 and neuropeptide FF (NPFF2) receptor. In our laboratory lipidized analogs of PrRP were synthesized, which are able to decrease food intake after peripheral administration and may cross the blood-brain barrier. We tested biological...
Mechanisms of potential toxic effects of bisphenol A on the endocrine system
Zachardová, Lenka ; Novotný, Jiří (advisor) ; Rupert, Marian (referee)
Bisphenol A (BPA) has already been used in the chemical industry for several decades. Since that time, a huge amount of in vitro and in vivo studies have been accumulated summarizing the molecular mechanisms of BPA causing disruption in endocrine homeostasis in all kinds of biological models. It enters the body from external environment; however, the main source of penetration is through consumption of food and liquids that are in contact with materials containing the mentioned xenoestrogen. The hydroxyl group within BPA phenol ring enables binding to transmembrane G- protein-coupled estrogen receptors and a number of nuclear receptors affecting hormonal system and resulting in alterations in signalling pathways. BPA induces oxidative stress and interferes with regulation factors functions at gene, cell and tissue level. Disruptive effects are associated with developmental, reproductive, cardiovascular, immune and neurobiological disorders. This thesis is aiming to sum up existing findings about the molecular mechanisms of BPA toxicity in the endocrine system mainly using Mus musculus model. Keywords: BPA, endocrine system, nuclear receptors, GPER, oxidative stress.
Transfer regulations in Czech hockey and its impacts
Matějček, Martin ; Crossan, William Morea (advisor) ; Novotný, Jiří (referee)
Title: Transfer regulations in Czech ice hockey and its impacts Objectives: The main goal of this work is, by research, to evaluate the functioning of the current transfer rules in Czech ice hockey and to reveal its shortcomings. Subsequently, to develop proposals for its modifications, which can be applied in the Czech hockey environment. Methods: To obtain the necessary data, the research consists of both quantitative and qualitative parts. Thus, a combination of two methods was used, namely electronic questioning and in-depth interview. The work also used the method of document analysis - the current transfer regulations. The shortcomings and subsequent impacts on the environment of ice hockey have been ascertained from the first expert, and what are the reasons for functioning in current form, from the second one. In both cases, the interview took place as an interview using instructions. Development diagrams were created to interpret the results. To verify the results of in-depth interviews and to find out the possibility of applying potential changes, an electronic survey was conducted among the representatives of individual clubs. Results: The research has shown that the current transfer rules actually have several problems that can negatively affect individuals, but also the hockey...

National Repository of Grey Literature : 270 records found   1 - 10nextend  jump to record:
See also: similar author names
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