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Wall shear stress and its role in progress of atherosclerosis
Chytilová, Eva ; Malík, Jan (advisor) ; Horký, Karel (referee) ; Piťha, Jan (referee)
Atherosclerosis is associated with systemic risk factors such as hypertension, hyperlipidemia, diabetes mellitus and smoking. Nonetheless, atherosclerosis is a focal disease, preferentially affecting predisposed areas. The main local hemodynamic factor is wall shear stress, the frictional force acting tangencially on the endothelial cell surface. The effect of wall shear stress depends on its magnitude and direction, as well as on the characteristic of vessel geometry and blood flow. Wall shear stress is an important determinant of endothelial function and phenotype. Previous research showed that arterial sites with chronically low WSS are more prone to the development of atherosclerotic plaques. Mostly, it is the case of outer wall of arterial bifurcations, where the stroma of vessel wall prevents arterio-constriction in response to low WSS. However, lower WSS was described also in straight arterial segments, such as carotid arteries, in the presence of atherosclerosis risk factors.
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Jehlička, Petr ; Piťha, Jan (advisor) ; Urbanová, Zuzana (referee) ; Malík, Jan (referee)
MUDr. JEHLIČKA SUMMARY This study has focused on a new method for the assessment of endothelial dysfunction (ED) using the Deceleration Index (DI). A total of 242 ultrasonographic examinations were performed in 92 children (FH 32, DM1 30, healthy controls 3O). The average DI values were 21.8%(±9.4)in healthy children, 19.9%(±9)in FH and 17.6%(±14)in the DM1 group. There were statistically insignificant differences between the study groups. This was most probably due to the high biological variability of the method employed. The coefficient of variation of DI was 1.02 (0.68 -1.53). Therefore, the clinical usefulness of DI is limited with regards to the individual assessment of ED and thus for the prediction of cardiovascular risk. The association of ADMA and oxLDL with ED and their superior sensitivity compared to DI and FMD has been confirmed in our study. Folic acid supplementation did not lead to a statistically signifiant improvement of DI and FMD. Similarly, plasma levels of ADMA and oxLDL remained unchanged despite a decrease of homocysteine and hsCRP in these children. This finding demonstrates a complicated relationship between ADMA, homocysteine and folic acid. The protective effect of folic acid on ED in high risk children was not confirmed in this study.
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Stavební řízení v praxi
Malík, Jan
This bachelor thesis deals with the analysis and description of current legislation of the building control and the planning permission procedure. The theoretical part contains an analysis of the building control and planning permission procedure, including the current building code and changes in building law. The practical part focuses on specific example of building a house. The discussion is a summary of the positives and negatives of changes in current building law.
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Service company process optimalization
Malík, Jan ; Kunstová, Renáta (advisor) ; Chocholatý, Drahomír (referee)
The theme of the diploma thesis deals with the description and improvement of business process inside of the service company. The Goal is to formalize current state of business processes in the Czech division of international hardware producer and provide overall view on the processes for the company management. In the first section there is a company profile described by organisation chart, strategy, SWOT analysis and brief description of the internal information system. The middle part contains descriptive tables and Event-driven process chains of three main processes and their subprocesses. In the all processes there are identified few weaknesses that are the base for the last section. The final part suggests specific improvements to the weaknesses. It is author's proposals for solving difficulties inside of the processes. In conclusion all of the plans are grouped by every single role in the process.
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Forms of electronic money
Malík, Jan ; Rydzi, Daniel (advisor) ; Zaoral, Ondřej (referee)
The intention of this work is to supply compact overview of most used forms of electronic money from the user's point of view. These forms represent kinds of products of payment methods available in the Czech Republic. First part contains facts about the evolution of bank cards in the whole world and about their short history in the Czech Republic. The work explains dif-ferences of various card types in two ways: type of record and the way, how the transaction is carried to account. Next part is focused on payment terminals from merchant angle of view. It contains real data of terminal payment records in a small shop. Based on this real-world example, there are costs necessary for maintaining of the terminal stated. At the end there are on-line payment options available on the Czech internet described. This information can help both e-shop's customers and e-shop itself.
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