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In vitro Mechanism of Action of Quinoxaline Derivate VN-034 on the Respiratory System
Machová, Iva ; Pourová, Jana (advisor) ; Vopršalová, Marie (referee)
Charles University in Prague Faculty of Pharmacy in Hradec Králové Department of Pharmacology and Toxicology Candidate: Mgr. Iva Machová Consultant: PharmDr. Jana Pourová, Ph.D. Title of Thesis: In vitro mechanism of action of quinoxaline derivate VN-034 on the respiratory system Abstract: The aim of this thesis was to investigate the mechanism of relaxation effect of quinoxaline derivative VN-034 in vitro, and to evaluate the potential of the substance to act as a β-agonist or M-antagonist. The classical in vitro method of isolated trachea was applied. In our experimental work VN-034 did not behave as a competitive β-agonist, however propranolol had an influence on its effect. On β-receptors, detailed mechanism of action could not be determined. On M-receptors, the substance behaved as a competitive antagonist.
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In vitro Mechanism of Action of Quinoxaline Derivate VN-034 on the Respiratory System
Machová, Iva ; Pourová, Jana (advisor) ; Vopršalová, Marie (referee)
Charles University in Prague Faculty of Pharmacy in Hradec Králové Department of Pharmacology and Toxicology Candidate: Mgr. Iva Machová Consultant: PharmDr. Jana Pourová, Ph.D. Title of Thesis: In vitro mechanism of action of quinoxaline derivate VN-034 on the respiratory system Abstract: The aim of this thesis was to investigate the mechanism of relaxation effect of quinoxaline derivative VN-034 in vitro, and to evaluate the potential of the substance to act as a β-agonist or M-antagonist. The classical in vitro method of isolated trachea was applied. In our experimental work VN-034 did not behave as a competitive β-agonist, however propranolol had an influence on its effect. On β-receptors, detailed mechanism of action could not be determined. On M-receptors, the substance behaved as a competitive antagonist.
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Mapping the needs of current and potential clients of parent centers in the city district Prague 13
Machová, Iva ; Francová, Tereza (advisor) ; Lukeš, Martin (referee)
The theoretical part of diploma thesis deals with the family, it's support by the State and other institutions, an analysis of childcare facilities - maternity centers, kindergartens, mini-kindergartens, nurseries, etc. Further analysis is directed to describe the purpose, operation and financing of the parent centers. Practical part of thesis deals with the analysis in the form of questionnaire survey of current and potential clients of parent centers in order to determine the availability, amenities, services, etc. of childcare facilities at Prague 13 in order to make recommendations for the further development of parent center Prokůpek.
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Finanční analýza společnosti Stock Plzeň, a.s.
Machová, Iva ; Olejníková, Hana (advisor) ; Mikan, Pavel (referee)
Bakalářská práce je rozdělena do tří částí - úvodu, teoretické a praktické části, které na sebe svojí témetikou navazují. První oddíl obsahuje základní informace a cíle. Druhý oddíl spolu s jednotlivými podkapitolami je zaměřen na teoretické vysvětlenní pojmů a ukazatelů finanční analýzi, které budou aplikovány prakticky na společnost Stock a.s. Poslední oddíl je věnován představení společnosti, její historii, struktuře, produkci a následné aplikaci jednotlivých ukazatelů z teoretické části přímo na konkrétní firmu, která je porovnána s odvětvím potravinářského průmyslu.
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