National Repository of Grey Literature 11 records found  1 - 10next  jump to record: Search took 0.00 seconds. 
Nové nukleosidfosfonové kyseliny jako inhibitory thymidinfosforylázy
Kočalka, Petr ; Rinnová, Markéta ; Vaněk, Václav ; Rejman, Dominik ; Votruba, Ivan ; Tomečková, Ivana ; Králíková, Šárka ; Petrová, Magdalena ; Páv, Ondřej ; Pohl, Radek ; Buděšínský, Miloš ; Liboska, Radek ; Točík, Zdeněk ; Rosenberg, Ivan
Several sugar-modified thymine-containing nucleoside phosphonic acids were found as a strong inhibitors of thymidine phosphorylase purified from spontaneous T-cell lymphomas of an inbred Sprague-Dawley rat strain.
Oligo-3'-deoxynukleotidy s chirální alfa-hydroxyfosfonátovou 2',5' internukleotidovou vazbou: zlepšení hybridizační selektivity vůči RNA?
Králíková, Šárka ; Buděšínský, Miloš ; Liboska, Radek ; Páv, Ondřej ; Rosenberg, Ivan
Synthesis and hybridization selectivity of 9-mers 5’-d(GTG ATA TGC)-3’ (T means modified units) containing both hydroxyphosphonate and phosphodiester 2’-5’ internucleotide linkages toward complementary DNA and RNA counterpart were investigated.
Monomery pro nové fosfonátové oligonukleotidy, potenciální inhibitory RNasy L
Liboska, Radek ; Páv, Ondřej ; Rosenberg, Ivan
Synthetic route for the preparation of 2',3'-O-phosphonoalkylidene , and 3',5'-O-phosphonoalkylidene ribonucleotide monomers for automated oligonucleotide synthesis (a phosphotriester condensation approach) has been developed.
From nucleoside phosphonic acids to modified oligonucleotides
Rosenberg, Ivan ; Endová, Magdalena ; Králíková, Šárka ; Liboska, Radek ; Rejman, Dominik ; Točík, Zdeněk
A number of new isopolar phosphonate nucleotide analogues were prepared and a large set of oligonucleotides containing structurally diverse modification internucleotide linkages could be created.
Isosteric phosphonate mono-and oligonucleotides originating from 4',5'-didehydronucleoside precursors: some synthetic possibilities and limitations
Točík, Zdeněk ; Liboska, Radek ; Barvík, I. ; Buděšínský, Miloš ; Masojídková, Milena ; Kavenová, Ivana ; Rosenberg, Ivan
The work deals with aspects of synthesis and properties of isosteric phosphonate analogs of 5'-monophosphates and with structure-properties relationship of the related oligothymidylates.

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