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National Repository of Grey Literature

49 records found  40 - 49  jump to record:

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	Indukce efektivní protinádorové imunity při léčbě směrovaným konjugátem na bázi poly(HPMA) obsahujícím doxorubicin Kovář, Marek ; Tomala, Jakub ; Mrkvan, Tomáš ; Etrych, Tomáš ; Strohalm, Jiří ; Ulbrich, Karel ; Říhová, Blanka Thus, treatment with B1 mAb-targeted conjugates is able to completely cured BCL 1 bearing mice and most importantly, break immunoescaping mechanisms of BCL1 cells Detailed record
	Směrovaná polymerní léčiva pro terapii nádorových onemocnění Kovář, Marek ; Mrkvan, Tomáš ; Šírová, Milada ; Strohalm, Jiří ; Šubr, Vladimír ; Etrych, Tomáš ; Ulbrich, Karel ; Říhová, Blanka We have presented data on development of polymer-bound cytostatic drugs and their therapeutic efficacy in selected tumor models Detailed record
	Anti-cancer drugs with immunoprotective/immunomodulatory effect Říhová, Blanka ; Etrych, Tomáš ; Kovář, Marek ; Chytil, Petr ; Hovorka, Ondřej ; Plocová, Daniela ; Mrkvan, Tomáš ; Strohalm, Jiří ; Šírová, Milada ; Šubr, Vladimír ; Kubáčková, K. ; Ulbrich, Karel Cytotoxic drugs based on HPMA polymer show direct cytotoxic and cytostatic effect together with an ability to mobilize the immune system. Two types of linkage of the drug to the polymer are discussed, as well as linkage-related differences in tumour cell accumulation and fate of the cells Detailed record
	Dual cytostatic and immunostimulate activity of polymericdrugs Říhová, Blanka ; Strohalm, Jiří ; Kubáčková, K. ; Jelínková, Markéta ; Rozprimová, L. ; Kovář, Marek ; Šírová, Milada ; Plocová, Daniela ; Mrkvan, Tomáš ; Etrych, Tomáš ; Pokorná, Jindřiška ; Ulbrich, Karel Classic chemotherapy is toxic for all intensively proliferated cells and tissues. Detailed record
	Immunological activity of HPMA-doxorubicine copolymer: experiment and clinical study Šírová, Milada ; Strohalm, Jiří ; Kubáčková, K. ; Rozprimová, L. ; Jelínková, Markéta ; Kovář, Marek ; Mrkvan, Tomáš ; Pokorná, J. ; Renčiuk, Daniel ; Etrych, Tomáš ; Ulbrich, Karel ; Říhová, Blanka Cytostatics bound to various types of polymers representone of the most promising ways in treatment of cancer. Detailed record
	T buňky mají zásadní úlohu při vytvoření protinádorové imunity u myší léčených protilátkou směrovanými konjugáty doxorubicinu a HPMA Mrkvan, Tomáš ; Kovář, Marek ; Etrych, Tomáš ; Strohalm, Jiří ; Plocová, Daniela ; Ulbrich, Karel ; Říhová, Blanka Anti-idiotype monoclonal antibody targeted N-(2-hydroxypropyl)methacrylamide copolymer bound doxorubicin is able to completely cure mice with BCL-1 B-cell leukemia. During the treatment the immune system is activated and effective long-term anti-tumor immunity is established. This immune reaction requires CD4+ and CD8+ cells. Detailed record
	Antracyklinová antibiotika na bázi protilátkou směrovaného HPMA Říhová, Blanka ; Strohalm, Jiří ; Jelínková-Ibrahimová, Markéta ; Kovář, Marek ; Šubr, Vladimír ; Etrych, Tomáš ; Mrkvan, Tomáš ; Šťastný, Marek ; Plocová, Daniela ; Šírová, Milada ; Hovorka, Ondřej ; Kubáčková, K. ; Ulbrich, Karel Conjugates based on N-(2-hydroxypropyl)methacrylamide represent a new generation of polymeric anticancer drugs with improved therapeutic potential and considerably decreased nonspecific side effects. Antibody -targeted derivatives show specific active targeting and nonspecific passive accumulation in solid tumors. Detailed record
	Exprese genů pro signalizaci apoptozy u buněk vystavených účinku HPMA konjugátů doxorubicinu Kovář, Lubomír ; Kovář, Marek ; Šťastný, Marek ; Strohalm, Jiří ; Etrych, Tomáš ; Ulbrich, Karel ; Říhová, Blanka We compared influence of hydrolytically and enzymatically cleavable conjugates based on N-(2-hydroxypropyl)methacrylamide on proliferatin activity and expression of mRNA of genes involved in apoptotic signalling pathway. We found elevated expression of Fas and bax mRNA in cells incubated with hydrolytically cleavable conjugates. Detailed record
	Protinádorová směrovaná léčba na bázi HPMA: základní principy pro syntézu konjugátů a převod z laboratoře do kliniky Říhová, Blanka ; Strohalm, Jiří ; Prausová, J. ; Kubáčková, K. ; Jelínková, Markéta ; Rozprimová, L. ; Šírová, Milada ; Plocová, Daniela ; Etrych, Tomáš ; Šubr, Vladimír ; Mrkvan, Tomáš ; Kovář, Marek ; Ulbrich, Karel Conjugates of N-(2-hydroxypropyl)methacrylamide with doxorubicin containing human IVIg were used for palliative treatment in patients with advanced cancer. More thena 116 biochemical and immunological parameters were tested. A decrease of some parameters with patological values was seen, and physiological values were occasionally reached, including some TAA. Detailed record
	Polymerní protirakovinná léčiva s pH- a enzymaticky závislou aktivací Etrych, Tomáš ; Chytil, Petr ; Strohalm, Jiří ; Jelínková, Markéta ; Kovář, Marek ; Říhová, Blanka ; Ulbrich, Karel Water-soluble synthetic polymers and their conjugates with antibodies, oligopeptides or saccharides proved a potential targetable drug delivery system. Recently, copolymers of N-(2-hydroxypropyl)methacrylamide (HPMA) have been developed in our laboratory as polymeric carriers of drugs. Detailed record

National Repository of Grey Literature : 49 records found   40 - 49  jump to record:

See also: similar author names
12	KOVÁŘ, Michal
12	Kovár, Michal
30	Kovář, Martin
4	Kovář, Matouš
2	Kovář, Matěj
12	Kovář, Michal
2	Kovář, Milan
5	Kovář, Miroslav

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