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Analysis of drug utilization of antibiotics for systematic administration in the Czech Republic in 2005-2019
Suchopárová, Lenka ; Malý, Josef (advisor) ; Kolář, Jozef (referee)
Analysis of drug utilization of antibiotics for systematic administration in the Czech Republic in 2005-2019 Author: Lenka Suchopárová Tutor: doc. PharmDr. Josef Malý, Ph.D. Consultant: Mgr. Petr Domecký Department of Social and Clinical Pharmacy, Faculty of Pharmacy in Hradec Králové, Charles university Introduction and aims: Antibiotics (ATB) are substances with a bacteriostatic or bactericidal effect. Treatment with ATB carries a risk of side effects, drug interactions and risk of resistance occurence. The reason for monitoring the consumption of ATB is not only the apparent coherence between their consumption and the increase of resistance, but also the economic side of bacterial infections treatment. The aim of this study was to analyze the consumption of ATB for systematic administration in the Czech Republic (CR) in 2005-2019. Methods: The analysis of the consumption of ATB was performed as a retrospective analysis of data from the database of the State Institute of Drug Control in the period from 1. 1. 2005 to 31. 12. 2019. Anatomical-therapeutic-chemical classification based on defined daily doses (DDD) of individual drugs was used for the analysis. The consumption of ATB was calculated as DDD per thousand inhabitants per day (TID). The data on the number of residents was acquired from the...
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The aspects influencing the therapeutic value of anticoagulants in the Czech Republic
Dvořáčková, Simona ; Kolář, Jozef (advisor) ; Trejtnar, František (referee) ; Tesař, Tomáš (referee)
Charles University, Faculty of Pharmacy in Hradec Králové Training Workplace Department of Social and Clinical Pharmacy Doctoral Degree Program Clinical and Social Pharmacy Candidate Mgr. Simona Dvořáčková Supervisor doc. RNDr. Jozef Kolář, CSc. Advisor doc. PharmDr. Josef Malý, Ph.D. Title of Doctoral Thesis The aspects influencing the therapeutic value of anticoagulants in the Czech Republic Background and aim: Anticoagulants prevent the onset or maintaining of thromboembolic (TE) diseases. Both long-term used drugs, the disadvantages of which may limit treatment, and newer ones, the benefits of which may be limited by shorter clinical experience, are currently approved. Drug utilization may be an important indicator of trends in drug use, as well as pharmacovigilance surveillance and the benefits and risks assessment in clinical practice. Research related to the evaluation of the therapeutic value of anticoagulants and the factors influencing their use in clinical practice contribute to safer pharmacotherapy, therefore the aims of this thesis were: 1) to analyze the drug utilization of parenteral and oral anticoagulants (OACs) in the Czech Republic (CR) between the years 2007-2020; 2) to evaluate the numbers and characteristics of spontaneously reported suspected adverse drug reactions (ADRs)...
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The Importance of Self-Reported Medication Adherence in the Evaluation of the Effectiveness of Pharmacotherapy
Ládová, Kateřina ; Matoulková, Petra (advisor) ; Červený, Petr (referee) ; Lukáš, Milan (referee) ; Kolář, Jozef (referee)
Charles University in Prague, Faculty of Pharmacy in Hradec Králové Department of Social and Clinical Pharmacy Candidate: Mgr. Kateřina Ládová Supervisor: PharmDr. Petra Matoulková, Ph.D.; PharmDr. Magda Vytřísalová, Ph.D. (Consultant) Title of Doctoral Thesis: The Importance of Self-Reported Medication Adherence in the Evaluation of the Effectiveness of Pharmacotherapy Introduction and Objective: Medication adherence (MA) is a highly variable factor affecting the response to the therapy. Especially in chronic disease, non-adherence presents a problem that may have health, social, and even economic consequences. Measuring MA is the most often performed by self-reported surveys which enables, among others, their simple application in research as well as in every day clinical practices. Self-reported MA monitoring may contribute to maximizing the effectiveness of pharmacotherapy and minimizing the risk of therapy failure, however, standardization of measuring process is needed. Moreover, some factors such as healthy adherer effect (HAE), which reflect patient health seeking behaviour but cannot be easily monitored, can favourably affect health outcomes. Acquired results may then be incorrectly attributed to drug therapy examined in the study. Hence, the main aims of this doctoral thesis were: 1) to...
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Antibiotic use by pharmacy employees
Duvanova, Natalia ; Vlček, Jiří (advisor) ; Kolář, Jozef (referee)
Charles University in Prague, Faculty of Pharmacy in Hradec Králové Department of social and clinical pharmacy Candidate Natalia Duvanova Consultant Prof. RNDr. Jiří Vlček, CSc. Title of Thesis «Antibiotic use by pharmacy employees» Introduction: This thesis discusses the issue of the purchase and use of antibiotics pharmacy employees in Saint-Petersburg, Russian Federation. The objectives of the study were to investigate their level of knowledge, attitudes, and behaviors regarding antibiotics. The frequency of consulting the pharmacists about diseases that often require antibiotics is rather high among patients in the Russian Federation. And many pharmacists provide their recommendations. Opinion polls held by WCIOM (Russian Public Opinion Research Center) in 2011 showed that 46% of respondents believe antibiotics kill viruses. Moreover, since 2007 this figure has even increased slightly - then it was 45%. According to the European Surveillance of Antimicrobial Consumption (ESAC) total outpatient antibiotic use in Russian Federation from 1997 to 2009 expressed in DDD per 1000 inhabitants and per day was 9.8 (2003), 9.3 (2004), 9.1 (2005), 9.6 (2006), 10.2 (2007), 10.0 (2008) and 12.2 (2009). Methodology: A cross-sectional survey was conducted on a random sample of 308 respondents using a...
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System of Education of Pharmacists in Greece
Mougiou, Eirini-Georgia ; Kotlářová, Jana (advisor) ; Kolář, Jozef (referee)
SYSTEM OF EDUCATION OF PHARMACISTS IN GREECE Author: Eirini-Georgia Mougiou Tutor: RNDr. Jana Kotlářová, Ph.D. Department of social and Clinical Pharmacy, Faculty of Pharmacy in Hradec Kralove, Charles University in Prague, Czech Republic Aim of study: The aim of diploma thesis is to get current knowledge about system of education of pharmacists in Greece, their vocational employment and to shortly compare situation in this field in Greece with Czech Republic. A survey whose goal is the gathering of information from foreign students about their experience in universities abroad, especially at Charles University. Methods: Data collection through appreciation of information and studying of literature. Questionnaire answered by 61 following students of pharmacy on March 2013. Results: Studies in high school, entrance examination of students in University , undergraduate and postgraduate studies in discipline of pharmacy are the main characteristics of both educational systems. Comparison and report of differences between the studies in Greece and studies abroad. Importance of life-long learning for professional pharmacists. Students answered questionnaire are 47,54 % males and 52,46 % females, most of them 68,84 % are from Greece and 14,74% from Cyprus. 67,21 % are not satisfied with Charles...
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Pharmacies in Greece
Zacharakis, Georgios ; Kotlářová, Jana (advisor) ; Kolář, Jozef (referee)
PHARMACIES IN GREECE Author: Georgios Zacharakis Tutor: RNDr. Jana Kotlářová, Ph.D. Department of Social and Clinical Pharmacy, Faculty of Pharmacy in Hradec Kralove, Charles University in Prague, Czech Republic Aim of diploma thesis: The aim is to get current facts and knowledge about the situation of pharmacies in Greece, including their basic problems, and to compare it with the Czech Republic. Methods: Data collection through appreciation of information and studying of literature, esp. Greek legislation. Results: It was given necessary information on the National Health System in Greece and about place and role of pharmacies in this. The main part of thesis deals wits pharmacies in Greece (legislation, statistics, pharmacists, activities in pharmacy). There are many private community pharmacies and low amount of hospital pharmacies which are only for inpatients. Both Greece and Czech Republic made considerable efforts in latest years to harmonize their legislation to the European standards. However, a significant difference between Greece and Czech Republic is profit margins of wholesalers, which are higher in the Czech Republic in comparison to Greece, while the production of drugs in Greece is significant higher than Czech Republic, which based more in its neighboring countries for the supply...
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Selected Organization and Association for Pharmacists in Greece
Papamichail, Christina ; Kotlářová, Jana (advisor) ; Kolář, Jozef (referee)
SELECTED ORGANIZATION AND ASSOCIATION FOR PHARMACISTS IN GREECE Author: Christina Papamichail Tutor: RNDr. Jana Kotlářová, Ph.D. Department of Social and Clinical Pharmacy, Faculty of Pharmacy in Hradec Kralove, Charles University in Prague, Czech Republic Aim of study: The aim of Diploma thesis was to get current knowledge about the selected organizations and associations for pharmacists in Greece, especially about the Panhellenic Pharmaceutical Association (PFS), their role, interconnection and influence not only in the selected part of society such as pharmacists but in the society in Greece generally and to shortly compare the situation these vocational organizations in Greece and in Czech Republic. Methods: The data collection through appreciation of information from different reliable internet sources, Greek legislation, as well from discussion with members of PFS. The paper form of literature is for this topic limited. Results: The role of the PFS in Greece is the same vital as the role of Czech Chamber of Pharmacists in Czech Republic (CLNK). The most important difference between them is in membership. In Greece due to the difficult and strictly conditions in the field of economy the role of the chamber is essentially inactive in comparison with the CLNK. The reason of this inactivity is...
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Non-prescribed antibiotic use in some developing countries and its association with drug resistance
Belkina, Tatiana ; Kolář, Jozef (advisor) ; Špliňo, Miroslav (referee) ; Tesař, Tomáš (referee)
Charles University, Faculty of Pharmacy in Hradec Králové Department of Social and Clinical Pharmacy Candidate Tatiana Belkina, MSc Supervisor doc. RNDr. Jozef Kolář, CSc. Title of Doctoral Thesis Non-prescribed antibiotic use in some developing countries and its association with drug resistance Background and Aims: The global emergence and spread of antimicrobial resistance remain a major challenge to infection control and a predominant reason for therapy failure. Non-prescription access to antimicrobials is common, and self- prescribing is increasingly popular in a society with non-regulated access to antimicrobials. It is crucial to avoid self-medication in order to combat antimicrobial resistance. This research need has been addressed within 4 scientific projects with the following aims: P1: We examined knowledge, attitude and practices of antibiotic use in 3 Asian countries and estimated the frequency and reasons for self- medication. P2: This study aimed to evaluate the extent of delay in diagnosis and treatment of tuberculosis in Uzbekistan and identify associated risk factors. P3: To evaluate knowledge of antibiotics, race, gender and age as independent risk factors for self-medication. P4: The aim of this study was to assess the attitudes of community pharmacists regarding antibiotic use...
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Selected Informations about Medicinal Products III. - Pharmindex kompendium
Čechová, Lenka ; Kotlářová, Jana (advisor) ; Kolář, Jozef (referee)
SELECTED INFORMATIONS ABOUT MEDICINAL PRODUCTS III. - PHARMINDEX KOMPENDIUM INVESTIGATION FOCUSED ON PATIENT'S HAIR LOSS Author: Čechová L., Lékárna Vitapharma, Tusarova 36, 170 00 Praha 7 Scientific Advisor (Tutor): Kotlářová J., Department of Social and Clinical Pharmacy, Faculty of Pharmacy in Hradec Kralove, Charles University in Prague, Czech Republic ------------------------------------------------------------------------------------------------------------------------------------------------------ Introduction: The main mission of current pharmacists is to provide quality pharmaceutical care to their patients, which requires continual education and learning. Objective: The dissertation consists of two studies. The first study sets itself the goal of providing a comprehensive overview of the five selected adverse manifestations of pharmacotherapy, namely the effect on hair and body hair (quantity and quality), sweating as affected by the drugs administered, the interaction between medicines and ingested alcohol or the alcohol content in medication, the likelihood of developing drug addiction, and the occurrence of hallucinations. The aim of the second study is to gain practical knowledge and opinions of patients on one of the observed negative effects of drugs - hair loss and other hair -...
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Hospital Drug Formularies in the Czech Republic
Kočí, Michal ; Kolář, Jozef (advisor) ; Kotlářová, Jana (referee)
Charles University in Prague, Faculty of Pharmacy in Hradec Králové Department of Social and Clinical Pharmacy Candidate Mgr. Michal Kočí Consultant doc. RNDr. Jozef Kolář, CSc. Title of Thesis Hospital Drug Formularies in the Czech Republic Drug formularies have been used for more than 50 years. Their importance in the hospital sector is increasing as more and more therapeutic alternatives arise and the drug-costs grow as well. Hospital drug formulary system is one of the most widely used mechanisms hospitals use to optimise their drug policy. The goal of the thesis was to evaluate the usage of the system on the sample of the Czech hospitals and to offer potential improve-ment. The starting point was to compile the current knowledge on the hospital drug formulary usage. The questionnaire based on the found data was designed to obtain the information on drug formulary system usage in the particular hospital. Then the questionnaire was sent to various Czech hospitals; at the same time, the questionnaire (translated into English) was sent to a German university hospital. By analyzing the obtained data a summary on up-to-date state of hospital drug formulary usage in the Czech Republic was produced. The principal result is that out of thirteen hospitals that sent the required information back, three...
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