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Magnetic nanoparticles of iron oxides for medicine
Kubániová, Denisa ; Kohout, Jaroslav (advisor) ; Mašláň, Miroslav (referee) ; Šepelák, Vladimír (referee)
Magnetic nanoparticles of iron oxides, particularly those of ferric oxides, magnetite, substituted variants, including functional derivatives, have attracted significant interest because of promis- ing capabilities in emerging diagnostic imaging methods and novel therapeutic interventions. In addition to the rapid development of syntheses and functionalization methods, a comprehen- sive understanding of their fundamental physical characteristics and the complex link among composition, microstructure, magnetic properties, and relaxation characteristics is pivotal for the rational design of well-defined magnetic nanoparticle systems. Generally, the magnetic behavior of nanoparticles deviates from bulk materials not only due to finite-size and surface effects but also by the occurrence of new crystal structures (polymorphs) and metastable states, such as non-equilibrium cation distribution. The doctoral thesis investigates the key physical characteristics of selected nanoparticle systems (simple ferric oxides of various crystal struc- ture and morphology; Zn-, Co- and Mn-substituted magnetite-maghemite; coated by various hydrophilic and biologically inert surface layers), primarily by 57 Fe Mössbauer spectroscopy and supplemented by other available techniques. For that purpose, Mössbauer spectroscopy that...
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Optimization of manufacturing process of tubes
Kohout, Jaroslav ; Staněk, Vojtěch (referee) ; Podaný, Kamil (advisor)
Elaborated thesis presents a proposal to increase welding speed in the process of production of stainless steel tubes 1.4301 and 1.4404. Based on analysis of the existing method was evaluated, that performance improvement would be most appropriate by adjusting the welding technology. Four methods have been proposed, describing the principle, andvantages and disadvantages. The most effective and cheapest was the modification of the existing TIG method using two torches, with the possible improvement of using another shielding gas.
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OpenSSL-based client-server system
Kohout, Jaroslav ; Janovič, Filip (referee) ; Malý, Jan (advisor)
Aim of this diploma thesis is study of possibilities of OpenSSL extension in PHP environment and its implementation in securing client-server system example. This system will be use to store confidential data. Whole system will be exemplar of securing against scale of attacks leads to gain private data.
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Modification of a laser welding system for welding materials releasing excessive amounts of fumes
Kohout, Jaroslav ; Sigmund, Marian (referee) ; Mrňa, Libor (advisor)
The thesis deals with the implementation of a suction system for laser welding. The specific product is grate used for outdoor drainage. The original GMAW production technology is to be replaced by a laser. During the welding of S235JR steel, a significant development of exhaust gases was observed, which subsequently made the actual process impossible. Practical experiments were performed and evaluated using tensile testing and metallographic cut. Based on the results, the optimal position of the suction nozzle and welding parameters were recommended. The obtained values were re-verified by experiment. Furthermore, a suitable extraction device was proposed and an economic evaluation was performed.
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Detection of quantized vortices in the zero temperature limit using silicon/superconducting microwires
Goleňa, Maximilián ; Schmoranzer, David (advisor) ; Kohout, Jaroslav (referee)
In this Thesis, we have characterized and used Microscopic Electrical Mechanical Oscillators (MEMS) in the study of quantum turbulence. Experiments were conducted in the temperature range of 20-920 mK in vacuum in various magnetic Ąelds and in superĆuid helium at temperature 20 mK. Resonance properties of MEMS in vacuum showed nonlinear behavior. Low drive peaks showed frequency softening, and high drive peaks showed frequency hardening. We showed that the origin of non-linear behavior lies in the geometry of MEMS. We have shown that our devices are superconductive in Ąeld 12.6 mT and is resistive for higher Ąelds. Resonance properties of MEMS do not signiĄcantly change with magnetic Ąelds in range 37.8-504 mT. We shown that the motion of MEMS in superĆuid helium is highly damped and all measured points were already in turbulent state. MEMS devices can be used to generate quantum turbulence or as itsŠ highly effective local probe. 1
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Study of hyperfine interactions in nanoparticles present in biological systems
Kubániová, Denisa ; Kohout, Jaroslav (advisor) ; Závěta, Karel (referee)
In the submitted bachelor thesis we studied iron oxides by zero-field and in-field Mössbauer spectroscopy at room and liquid helium temperature. The relative composition in synthe- tically prepared nanoparticles of ferric oxide in SiO2 matrix is investigated in dependence on ferric oxide concentration and heating temperature and further the phase composi- tion and structure of biological nanoparticles produced by Geoalkalibacter ferrihydriticus bacteries in dependence on concentration of quinone in the cultivating solution. By data analysis the chemical and phase composition of the samples and hyperfine parametres of 57 Fe cations in nonequivalent crystallographic positions are determined. 1
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Relaxivity of magnetic nanoparticles
Kubíčková, Lenka ; Kohout, Jaroslav (advisor) ; Lančok, Adriana (referee)
Magnetic nanoparticles have found broad applications in medicine, in particular as contrast agents for T1- and T2-weighted magnetic resonance imaging (MRI). The ability of a contrast agent to influence the proton relaxation rate in a tissue is described by its relaxivity. In the submitted bachelor thesis we characterise physical properties of samples of ε-Fe2O3 nanoparticles coated with amorphous silica (SiO2), particularly with the aim to determine the dependences of their relaxivities on the magnetic field, temperature and thickness of silica coating. The distribution of the particle sizes was derived from the TEM pictures giving the median ~ 20 nm and the thickness of the silica coating ~4; 8; 13; 19 nm. The lattice parameters and presence of ˂ 2% admixtures of α phase were ascertained by XRD analysis; hyperfine parameters obtained by Mössbauer spectroscopy indicate no change of magnetic properties of the particles by silica coating. The relative amount of ε-Fe2O3 and SiO2 in the samples was specified from the magnetic measurements. Aqueous suspensions of different concentrations of coated nanoparticles were prepared, and their relaxivities r1, r2 were measured in different magnetic fields. Temperature dependence of relaxivities of a chosen sample was obtained in fields 0.47 T and 11.75 T....
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Spherically symmetrical thermal counterflow of superfluid helium
Novotný, Filip ; Schmoranzer, David (advisor) ; Kohout, Jaroslav (referee)
The principal aim of this Thesis was the investigation of quantum tur- bulence in superfluid helium in a special type of flow, spherically symmetric thermal counterflow. To this end, a new cell was designed and 3D-printed. Measurements of quantum turbulence were realized using the traditional technique of second sound attenuation, focusing both on steady state of tur- bulence and its temporal decay. The measured dependence of the quantized vortex line density L versus the counterflow velocity vns, where the data clearly show that L ∝ v3/2 ns , does not agree with the Vinen equation, which predicts L ∝ v2 ns. On the other hand, the dependence of vortex line density on time t obtained during the decay measurements L ∝ t−1 is paradoxically in close agreement with the Vinen equation. For the future, spherically sym- metrical thermal counterflow thus promises many interesting challenges and will remain an important topic of research. 1
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Nuclear magnetic resonance of Pb(x)Ba(1-x)(FeNb)0.5O3 perovskites
Adamec, Martin ; Chlan, Vojtěch (advisor) ; Kohout, Jaroslav (referee)
Temperature dependences of nuclear magnetic resonance spectra of isotopes 207 Pb, 137 Ba, and 93 Nb in polycrystalline samples of PbxBa1-x(FeNb)0.5O3, with x = 0 (BFN), 0.5 (PBFN), 1 (PFN) and in Pb(FeNb)0.5O3 single crystal (PFN SC) were acquired. Measured nuclear magnetic resonance spectra are analyzed in this work. The temperature dependence of the spectra show strong broadening with decreasing temperature. Part of the temperature dependences of nuclear magnetic resonance spectra did not comply with expected characteristics. Possible hypotheses for interpretation of such behavior are discussed in the text. Probable arrangement of Fe and Nb cations in PFN and BFN phases is deduced and, based on these differences, the contrast in Néel temperatures of these phases is explained.
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Visualization of selected flows of water and cryogenic helium using tracer particles
Pilcová, Veronika ; Skrbek, Ladislav (advisor) ; Kohout, Jaroslav (referee)
Flow visualization techniques have recently been applied for the investigation of various cryogenic flows of liquid helium. Particle image velocimetry and particle tracking velocimetry techniques, proven in the past as very fruitful in many scientific and industrial areas of research, are being used for the analysis of cryogenic flows. The Joint Low Temperature Laboratory at the Charles University in Prague is the first in Europe to employ flow visualization techniques to investigate liquid helium flows. The approach had to be optimized due to a number of technical and fundamental dificulties, i.e., the optical access to the helium bath and choice of suitable tracer particles. Water experiments at room temperature were performed to prove that the experimental apparatus is well-suited for the low-temperature experiments performed as the main part of the work. The latter focused on thermal counter flow. The results from both, room-temperature experiments and low-temperature experiments are discussed and positively compared with well-known theoretical results.
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