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Measurement of bone density and its use for determination of biological age, prevention and indication of osteoporosis
Krátká, Jitka ; Ďoubal, Stanislav (advisor) ; Klemera, Petr (referee) ; Hála, Tomáš (referee)
The actual level of factual individual ageing of organism is characterized by biological age. By means of measuring function ability of physiological systems it is possible to evaluate the biological age and use it as an indicator of premature ageing and therefore as an indicator of the risk of getting ill. This study brings an overview of contemporary used, non-standard markers for the measurement of biological age and uncovers the possibility of measurement of biological age (BA) of skeleton and its use in osteoporosis precaution. Inclusion of BA measurement of skeleton into basic screening should bring another perspective how to measure objectively the changes in organism that correspond with ageing. Key words: biological age, osteoporosis, bone ageing, osteodenzitometry
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Biological age and its Influence Possibilities
Havranová, Jana ; Jezberová, Michaela (advisor) ; Klemera, Petr (referee)
BIOLOGICAL AGE AND ITS INFLUENCE POSSIBILITIES Biological age includes the changes which are related to the ageing. It can be influenced with environment, nutrition, lifestyle etc. Important factor of biological age is also psychical respectively spiritual part of lifestyle. It was proved people which meditate regularly have higher level of melatonin - the potentional marker of the biological age. The connection among the emotional intelligence quotient level, physical health and longevity was also found. Emotional intelligence development and meditation is with great success included into the studying programs at certain foreign high schools. The questionnaire study realized at Faculty of Pharmacy has shown that the students are exposed to stress during their studies, which has negative impact on their psychical and physical condition. The majority of these students are not able to deal effectively with the consequences of this kind of stress and they can appear as sleeping malfunction, capriciousness, nervousness, digesting problems etc. 46% of eighty respondents consider emotional control useful and thus they stimulate one of the factors which influence biological age. The students make an effort to moderate strain by sport, visiting friends etc. Emotional intelligence would help the students more...
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The effect of natural cosmetics on change the mechanical properties of the skin
Palátová, Jana ; Kuchařová, Monika (advisor) ; Klemera, Petr (referee)
Charles University in Prague, Faculty of Pharmacy in Hradec Kralove Department of biophysics and physical chemistry Candidate: Bc. Jana Palátová Supervisor: Mgr. Monika Kuchařová, Ph.D. Title of thesis: The effect of natural cosmetics on chase the mechanical properties of the skin This thesis in theoretical part deals with the structure of skin, its biochemistry and functions. Discusses the changes that the skin undergoes during development and aging. It describes the mechanical properties of the skin and the discipline that deals with these characteristics. The practical part deals with the measurement of mechanical parameters of human skin after application of a natural cream. The trial involved a total of ten women were about the same age. Measurements were performed on a dynamic elastomers being developed at the Department of Biophysics and Physical Chemistry of the Faculty of Pharmacy at Charles University in Hradec Kralove. The investigated parameters were Hooke and Newton factor. Hooke's coefficient indicates the elasticity of the skin, Newton coefficient of its viscosity. The results show that the test cream affected as skin elasticity, and its viscosity. In 90 % of the test persons there was a significant increase in the values of the Hooke and Newton coefficient and the resulting effect...
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Influence of preload on change of mechanical properties of the aortic walls
Veseleňáková, Eva ; Kuchařová, Monika (advisor) ; Klemera, Petr (referee)
Charles University in Prague Faculty of Pharmacy in Hradec Kralove Department of Biophysics and Physical chemistry Candidate: Eva Veseleňáková Supervisor: Mgr. Monika Kuchařová, Ph.D. Title of diploma thesis: The influence of preload on change of mechanical properties of the aortic walls The subject of this thesis is to monitor the influence of preload on change the mechanical properties of the aortic walls. Department of Biophysics and Physical Chemistry Faculty of Pharmacy of Charles University in Hradec Kralove studies the mechanical properties of the biological materials or synthetic materials for many years. The aim of this work is to continue research on measurements of the properties of the arterial walls, because the changes in the mechanical properties are associated with aging and may cause a wide range of cardiovascular diseases. The theoretical part is devoted to the anatomical and histological structure of the aorta walls. Summarizes theoretical knowledges of biomechanics and rheology of viscoelastic bodies. It describes the physiological functions and biophysics of the bloodstream. And also is focused on pathological changes that are related to changes in mechanical properties. The experimental part is focused on the type and preparation of biological material, creation of samples,...
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Influence of the Age and Other Factors on the Estrogen and Progesteron Receptor Ratio (ER/PR) in Breast Cancer
Hanáková, Tereza ; Hochmann, Jiří (advisor) ; Klemera, Petr (referee)
2. Summary Tereza Hanáková Influence of the age and other factors on the estrogen and progesteron receptor ratio (ER/PR) in breast cancer Rigorous thesis Charles university in Prague, Faculty of Pharmacy in Hradec Králové Pharmacy In this rigorous thesis we dealt with ER/PR ratio of patiets in the breast cancer and we tried to point out its importance for making the diagnostics more accurate. We compared the curves in the graphs of hospitals in Pardubice, Náchod and Hradec Králové by the help of methods that exploited medians of the neighbouring - mutually overlapping groups of patients. In these graphs we were noticing the similar or on the contrary different features and also abnormalities and we tried to explain the reason of these events. It is important to define the optimal ER/PR value and determine the boundary of the dangerously low or high ER/PR ratio, because the extreme increase of this quotient as well as too low of ER/PR ratio make the prognosis worse. The ER/PR quotient should represent the comming of the menopause more accuratelly than ER alone, because during low estradiol production not only concentration of ER, but also the extent of the whole ER/PR quotient rises, but in the addition, this ER/PR quotient rises together with the decrease of PR in the denominator. On the contrary, the...
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Mathematics and implementations of physiologically based pharmacokinetic modeling
Rakhimov, Yestay ; Duintjer Tebbens, Erik Jurjen (advisor) ; Klemera, Petr (referee)
Charles University Faculty of Pharmacy in Hradec Kr'alov'e Department of Biophysics and Physical Chemistry Candidate: Yestay Rakhimov Supervisor: doc. Erik Jurjen Duintjer Tebbens, Ph.D. Title of diploma thesis: Mathematics and implementations of physiologically based phar- macokinetic modeling The thesis addresses some basic aspects of pharmacokinetic modeling, which is used to describe pharmacokinetic processes. Understanding these processes is important for example to determine optimal concentrations of drugs dosing. The thesis focuses on mathematical proofs of a number of pharmacokinetic equa- tions, which are often not given in standard books. The derived equations are illustrated with numerical experiments for a particular drug in the software PharmCalcCl and MAT- LAB. 4
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