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Histopathological predictors of clinical course severity and development of surgical complications in children with inflammatory bowel diseases
Fabián, Ondřej ; Zámečník, Josef (advisor) ; Daum, Ondřej (referee) ; Karásková, Eva (referee)
The aim of the presented thesis is to summarize a benefit and limitations of histopathological assessment of bioptic samples for diagnostics and prediction of complicated course of the disease in children with inflammatory bowel diseases (IBD). We would also like to outline a potential benefit of more sophisticated histopathological methods in these domains. In the first phase of our research, we aimed at correlation of microscopical disease activity in children with Crohn's disease (CD) with activity assessed endoscopically and clinically. We also examined a histopathology as a possible predictor of development of complications, since previous works on adult cohorts indicate only a limited predictive value of microscopy. Our study confirmed this premise also for pediatric patients, since histopathological findings correlated weakly with endoscopy, didn't correlate with clinical activity of the disease and did predict none of the defined complications. On the other hand, endoscopy appeared to be a reliable predictor of complicated course of the disease. In the next part of our research, we were searching for other, more precise methods of assessment of histopathological disease activity that could serve as predictors of complications. We focused at immunohistochemical assessment of tissue...
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Cooperating defendant
Karásková, Eva ; Tejnská, Katarína (advisor) ; Galovcová, Ingrid (referee)
Cooperating defendant Abstract This thesis on Cooperating defendant is focused on the development of this institute, its connection to organized crime and relevant international and Czech legislation. The thesis consists of the introduction, five chapters, that each presents individual topics in detail, and the conclusion. The first chapter analyses historical development of the institute of crown witness and its connection to the institute of cooperating defendant, the context of adoption of this institute into the Czech legislation and the subsequent amendment of the relevant provisions. At the same time, it summarizes the planned changes concerning the institute of cooperating defendant within the framework of recodification of criminal procedure. The second chapter analyses organized crime in connection to the institute of cooperating defendant. It focuses on the occurrence of organized crime in the Czech Republic, its specific features and legislation, the purpose of which is to fight organized crime. The third chapter is focused on the international legislation of the institute of cooperating defendant, which is mainly defined by international organizations, such as the UN, the European Union and the Council of Europe. The current legal regulation of the institute of cooperating defendant is analysed...
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Effect of stress hormones on mesenchymal stem cells
Karásková, Eva ; Krulová, Magdaléna (advisor) ; Hejnová, Lucie (referee)
Mesenchymal stem cells (MSCs) are multipotent cells with the capacity to differentiate into cell lineages such as osteoblasts, adipocytes and chondrocytes. They maintain homeostasis in organism and contribute to wound healing and tissue regeneration. Usually, they are isolated from bone marrow or adipose tissue and they are primarily studied in regenerative medicine. Stress reaction is neurohumoral preparation for "fight or flight", that occurs in response to physical or mental stresssors. However, chronic stress has a negative impact on organism; it causes gradual exhaustion and damage in the whole body. Main hypothesis of this study is that stress hormones and neurotransmitters affect MSCs, which subsequently results in disturbed homeostasis and integrity of organism, delayed wound healing and attenuated tissue regeneration. Stress hormones influence quality and function of MSCs, especially their capabilities of differentiation, migration to wounded tissue and production of bioactive molecules. Key words: mesenchymal stem cells (MSCs), catecholamines, hormones, dopamine, nervous system, stress
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