|
| |
|
|
Iodine status among pregnant diabetic women
Radiměřská, Veronika ; Jiskra, Jan (advisor) ; Límanová, Zdeňka (referee)
Inroduction: The target of practical part was to verify the concentration of iodine in the urine (UIC) and its relation to the other thyroid parameters in the blood of pregnant diabetic women in second or third trimester of pregnancy. Methods: We have measured UIC in 163 pregnant women screened positive for pregestational or gestational diabetes in second trimester of pregnancy. I have worked later with results from 154 of them. Currently, serum levels of autoantibodies against thyroid peroxidase (TPOAb) and thyroglobulin (TgAb), thyroid-stimulating hormone (TSH), free thyroxine (FT4) and trijotyronin (FT3) were determined. Results: Median UIC was 91,15 ug/L (range 67,7-112 ug/l). At 136/154 (88 %) women UIC was lower than 150 ug/L, median 86,95 ug/L (range 64,95-106,4) and at 90/154 (58 %) was lower than 100 ug/L. UIC in the range with mild iodine deficiency (50-149 ug/L) was measured at 117/154 (76 %) women and 19 (12,3 %) values were found in the range of moderate UIC deficiency (20-49 ug/L). No value of UIC was lower than 20 ug/L. At 7 (4,5 %) women were measured levels in the adequate range for pregnant women (150-249 ug/L). At 11 women (7,2 %) was UIC higher than 250 ug/L. Conclusion: At 88 % pregnant diabetic women in second or third trimester of pregnancy was identified UIC values at...
|
|
|
Utilization of the database applications in clinical research
Telička, Zdeněk ; Jiskra, Jan (advisor) ; Doležal, Tomáš (referee)
The Diploma Thesis "Utilization of database applications in clinical research" deals with development of client-server database application for 3rd Medical Department, 1st Faculty of Medicine, Charles University in Prague. Application's aim is to store structured data of patients' examinations, treatments and biochemical results. Purpose of the application is to facilitate data processing for clinical research, which is very difficult, because information stored in hospital information system doesn't contain detailed records from medical examinations. Also, searching for several entries is slow. As well, application allows import patient identification data from hospital information system. This function provides physicians wide range of possibilities in data processing 4 and comparison in relation to treatments. Effective feature of this application is faster writing medical reports stored in information system because they are automatically generated from application's database.
|
|
|
Pathophysiology of primary congenital and early-onset non-autoimmune hypothyroidism
Al Taji, Eva ; Lebl, Jan (advisor) ; Dvořáková, Marcela (referee) ; Jiskra, Jan (referee) ; Stárka, Luboslav (referee)
Background: Thyroid dysgenesis (TD) and thyroid dyshormonogenesis clinically manifest as permanent primary congenital hypothyroidism (CH) and only rarely as non-congenital, postnatal non-autoimmune hypothyroidism. As basic molecular events underlying the regulation of thyroid development, growth and function were clarified in the last decade, molecular pathogenesis of TD and dyshormonogenesis has been intensively studied. Candidate genes for TD and dyshormonogenesis had been described and their mutations were subsequently detected in several patients with non-syndromic and syndromic CH. Nevertheless, no systematic population-based phenotype-focused molecular genetic analysis had been performed and concerning TD, the data regarded only a few individual patients. Aim: The aim of this extensive study was to identify monogenic forms of TD and dyshormonogenesis in a population-based cohort of Czech patients mostly with CH. Systematic mutation screening was based on a detailed clinical information and phenotype description, and thus focused on clinically defined subgroups of patients matching the phenotypes of already known candidate gene mutations.
|
|
| |
guest ::
