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Therapeutic influence of Sertoli cells on the effects of oxidative stress in germ cells
Hynková, Marie ; Tlapáková, Tereza (advisor) ; Frolíková, Michaela (referee)
Sertoli cells are somatic cells found in the testes and have a function in supporting spermatogenesis and germ cell nutrition, but also in maintaining an anti-inflammatory environment and forming the blood-testicular barrier in the testes. They are intensively researched for their immunomodulating properties which can be used in transplant medicine or as a therapeutic tool in regenerative medicine. Following previous research confirming that mouse Sertoli cells share some characteristics of mesenchymal stem cells and have multipotent differentiation potential in vitro, experiments were conducted to determine their therapeutic capabilities. Sertoli cells have demonstrated the ability to promote the maintenance of sperm motility during testicular inflammation and reduce the amount of immotile sperm in vivo. Based on preliminary results, they can also reduce the amount of ROS produced by testicular cells affected by oxidative stress in vitro. Keywords: Sertoli cells, germ cells, infertility, oxidative stress, ROS
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Maternal and fetal microchimerism.
Hynková, Marie ; Tlapáková, Tereza (advisor) ; Pačes, Jan (referee)
Microchimerism is defined as the presence of small amount of genetically distinct cells in one individual. It most often arises during pregnancy and breastfeeding. It can also arise from blood transfusion or organ transplantation. During pregnancy there occurs a bidirectional migration of cells through the placenta between the mother and the fetus. Cells which are transferred during pregnancy and breastfeeding can persist in the offspring until adulthood. During breastfeeding, a big number of immune cells is transferred to the offspring via mother's milk. These cells protect the offspring against pathogens and are involved in modulation of its immune system. Fetal cells persist in mother organism even decades after giving birth and can have long-lasting effect on mother's health condition. These fetal cells can help to regenerate mother's damaged tissues, but they can also contribute to the development of serious autoimmune diseases.
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Oprávněnost intervencí ČNB na devizovém trhu
Hynková, Marie
Hynková, M. The eligibility of the CNB interventions in the foreign exchange mar-ket. Diploma thesis. Brno: Mendel University in Brno, 2018. This diploma thesis deals with the monetary policy of the Czech National Bank after the financial crisis. The monetary policy of the CNB is compared with doings of the Federal Reserve and the European Central Bank. Attention is paid to the monetary policy of the CNB and to the reasons why the CNB has provided inter-ventions on the foreign exchange market in order to depreciate the CZK/EUR ex-change rate. The diploma thesis described in detail foreign exchange interventi-ons, which the CNB acceded on November 7, 2013, and subsequently abandoned them on April 6, 2017. The CNB wanted to influence the impending deflationary development in the country, so the diploma thesis also deals with the consequen-ces caused by the use of this non-conventional tool. The work also evaluates the benefits and costs of foreign exchange interventions. The empirical part of the diploma thesis demonstrates the relationship of inflation and the exchange rate CZK/EUR. There is also an appreciation of factors influencing the development of inflation during the intervention period.
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