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Drugs and people III.
Hudcová, Petra ; Práznovcová, Lenka (advisor) ; Zimčíková, Eva (referee)
15. SUMMARY DRUGS AND PEOPLE III. Author: Hudcová Petra (Department of social and clinical pharmacy, Faculty of pharmacy in Hradec Králové, Charles university in Prague) Tutor: PharmDr. Práznovcová Lenka, Ph.D. (Department of social and clinical pharmacy, Faculty of pharmacy in Hradec Králové, Charles university in Prague) Backgroud: Availability of drugs is limited by many factors. Economic factors are one of the most important. The financial participation of patients on drugs is one of basic metod for regulation the costs in health. Increase the financial participation of patients on drugs and reduction stae costs on pharmacotherapy (in cases where it's possible in terms of availability) may be increased the availability of more expensive pharmacotherapy. Aim of study: The aim of the theoretical work is mapping the current situatian in the Czech republic in relation to the price of drugs. Practical part of the work is focused on the evaluation research conducted among pharmacy clients in pharmacy "Koruna" located in West Bohemian town Ostrov. Methods: The survey was conducted through questionnaire "People and drugs". This questionnaire was created on Department of social and clinical pharmacy, Faculty Of Pharmacy in Hradec Králové. Data was obtained from clients pharmacy in term of November - December...
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Development and validation of HPLC method for determination of impurity 2-ethylpyridine in topical gel containing dimetindene maleate
Hudcová, Petra ; Hájková, Renata (advisor) ; Matysová, Ludmila (referee)
Title of graduation theses: Development and validation of HPLC method for determination of impurity 2-ethylpyridine in topical gel containing dimetindene maleate Petra Hudcová Charles University in Prague, Faculty of Pharmacy in Hradec Králové, Department of Analytical Chemistry A High Performance Liquid Chromatography method for the simultaneous determination of 2-ethylpyridine and dimetindene maleate in Fenistil® gel was developed and validated. Analytical column Supelco Discovery® Cyano (100 x 4 mm; 5 μm) and mobile phase composed of acetonitrile:ammonium secondary phosphate buffer 50 mM, pH 5.5, with addition of 0.5 ml of triethylamine in 100 ml buffer, 40:60 (v/v) were used for the chromatography. The flow-rate was 0.7 mL/min and the UV detection was accomplished at 258 nm. Diltiazem hydrochloride was used as internal standard. Substances were eluted in the following order: 2-ethylpyridine, diltiazem hydrochloride, dimetindene maleate. Validation parameters precision, accuracy, linearity, robustness, selectivity, limit of detection and limit of quantication were calculated. The system suitability test data (number of theoretical plates, asymmetry, resolution and repeatability of area and retention time) were tested.
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Development and validation of HPLC method for determination of impurity 2-ethylpyridine in topical gel containing dimetindene maleate
Hudcová, Petra ; Hájková, Renata (advisor) ; Matysová, Ludmila (referee)
Title of graduation theses: Development and validation of HPLC method for determination of impurity 2-ethylpyridine in topical gel containing dimetindene maleate Petra Hudcová Charles University in Prague, Faculty of Pharmacy in Hradec Králové, Department of Analytical Chemistry A High Performance Liquid Chromatography method for the simultaneous determination of 2-ethylpyridine and dimetindene maleate in Fenistil® gel was developed and validated. Analytical column Supelco Discovery® Cyano (100 x 4 mm; 5 μm) and mobile phase composed of acetonitrile:ammonium secondary phosphate buffer 50 mM, pH 5.5, with addition of 0.5 ml of triethylamine in 100 ml buffer, 40:60 (v/v) were used for the chromatography. The flow-rate was 0.7 mL/min and the UV detection was accomplished at 258 nm. Diltiazem hydrochloride was used as internal standard. Substances were eluted in the following order: 2-ethylpyridine, diltiazem hydrochloride, dimetindene maleate. Validation parameters precision, accuracy, linearity, robustness, selectivity, limit of detection and limit of quantication were calculated. The system suitability test data (number of theoretical plates, asymmetry, resolution and repeatability of area and retention time) were tested.
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Drugs and people III.
Hudcová, Petra ; Zimčíková, Eva (referee) ; Práznovcová, Lenka (advisor)
15. SUMMARY DRUGS AND PEOPLE III. Author: Hudcová Petra (Department of social and clinical pharmacy, Faculty of pharmacy in Hradec Králové, Charles university in Prague) Tutor: PharmDr. Práznovcová Lenka, Ph.D. (Department of social and clinical pharmacy, Faculty of pharmacy in Hradec Králové, Charles university in Prague) Backgroud: Availability of drugs is limited by many factors. Economic factors are one of the most important. The financial participation of patients on drugs is one of basic metod for regulation the costs in health. Increase the financial participation of patients on drugs and reduction stae costs on pharmacotherapy (in cases where it's possible in terms of availability) may be increased the availability of more expensive pharmacotherapy. Aim of study: The aim of the theoretical work is mapping the current situatian in the Czech republic in relation to the price of drugs. Practical part of the work is focused on the evaluation research conducted among pharmacy clients in pharmacy "Koruna" located in West Bohemian town Ostrov. Methods: The survey was conducted through questionnaire "People and drugs". This questionnaire was created on Department of social and clinical pharmacy, Faculty Of Pharmacy in Hradec Králové. Data was obtained from clients pharmacy in term of November - December...
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Rescue Stations for Wounded and Disabled Animals and Following the Daily Activities of Pigeons at Rescue Stations in Jinonicíce
Hudcová, Petra ; Battaglia, Daniel (referee) ; Řezníček, Jan (advisor)
The dissertation discusses first - aid stations for injuried and handicapped animals. The first part describes the origin of the National Net of Stations for injuried and animals handicapped otherwise (NNS), the activity and function of these stations and conditions that a station must fulfil to be accepted in the National Net of Stations. The second part of the dissertation discusses observation of pigeons in the first - aid station in Jinonice and describes this station. The pigeons were signed and after this they were observed and their activity was noted down. When compared to other specialist literature, no new information was found, the pigeons spend their time mostly bysleeping or sunbathing. The text contains return reports of birds ringed in Jinonice station and charts of surveys of recieved, decayed and released animals from the NNS. The sence of the dissertation rests in charting the net of stations for handicapped animals, their cooperation with schools and mentioned methodology of tagging pigeons. Methods of observing animals and their realization can be interpolated to biology, also. Students would get acquainted with the working of a station for handicapped animals and they would learn patience during observing and respect for nature, too. Powered by TCPDF (www.tcpdf.org)
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