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National Repository of Grey Literature

17 records found  11 - 17  jump to record:

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	Protective effect of E. coli strain Nissle 1917 and E. coli strain O83 on the development of inflammation in dextran sulphate sodium-induced colitis in mice Hudcovic, Tomáš ; Štěpánková, Renata ; Hrnčíř, Tomáš ; Kozáková, Hana ; Schwarzer, Martin ; Tlaskalová, Helena The study was focused on the evaluation of probiotic bacteria E. coli strain Nissle 1917 and E. coli strain O83 and their role in the development of intestinal inflammation in DSS model of ulcerative colitis and the route of the application. Intragastrically tubing SCID mice ( with severe combined immunodeficiency) had heavy chages (inflammation) of the colon – part descendens. Intrarectally application had a protective effect on the development of intestinal inflammation – part colon descendens. Proinflammatory cytokines TNF – alpha and IL – 6 were reduce markedly in fragment culture from colon - descendens Detailed record
	Influence of germ-free conditions on the development of sensitization and tolerance to the main compound of brich pollen Bet v 1 in mice Kozáková, Hana ; Repa, A. ; Štěpánková, Renata ; Hrnčíř, Tomáš ; Hudcovic, Tomáš ; Tlaskalová, Helena ; Pollak, A. ; Wiedermann, U. Birch pollen is one of the most frequent airborne allergen of Central and North Europe. The effect of intestinal microflora on sensitization and mucosal tolerance to main component of birch pollen Bet v 1 did not be study yet. Germ-free and conventional mice were administrated intragastrically or intranasally with Bet v 1 following by subcutaneous injections of Bet v 1. Tolerance was established independently on microflora present resulting decreased level of IgE and changed cytokine production Detailed record
	Vnímavost k navození nazální a orální tolerance je nezávislá na přítomnosti mikroflóry Repa, A. ; Kozáková, Hana ; Hudcovic, Tomáš ; Štěpánková, Renata ; Hrnčíř, Tomáš ; Tlaskalová, Helena ; Pollak, A. ; Wiedermann, U. The development of mucosal tolerance to major allergic component of birch pollen in relationship with presence of intestinal microflora was the aim of presented study. Germ-free (GF) or conventionally reared (CV) BALB/c mice were intragastrically or intranasally pre-treated with Bet v 1 prior to sensitization performed by subcutaneous injections of Bet v 1. Oral as well as intranasal tolerance induction led to a significant reduction of allergen-specific antibody levels and IgE basophil degranulation, as well as cytokine production in vitro in both GF and CV mice. The importance of the microflora for mucosal tolerance induction in GF mice remains therefore a matter of debate Detailed record
	Vliv střevních bakterií na vývoj kolitidy u SCID myší po přenosu CD4+CD45RB high T buněk a na změny těsných spojů (TJs) a Panetových buněk Štěpánková, Renata ; Powrie, F. ; Kofroňová, Olga ; Kozáková, Hana ; Hudcovic, Tomáš ; Hrnčíř, Tomáš ; Tlaskalová, Helena In the model of colitis developing in T cell reconstituted SCID mice pronounced morphological impairment of colon, was accompanied by structural changes of tight junctions and decreased expression of alpha defensins in terminal ileum Detailed record
	Vliv střevní mikroflóry na endotoxinový šok Hrnčíř, Tomáš ; Kobayashi, K. ; Flawell, R. A. ; Hudcovic, Tomáš ; Kozáková, Hana ; Štěpánková, Renata ; Tlaskalová, Helena Endotoxin shock is the most severe complication of sepsis. Lipopolysaccharide (LPS) or endotoxin, a structural component of gram negative bacteria, is a major effector and can activate the innate immune system and lead to multiple organ failure, termed endotoxin shock. In our project we study the effect of intestinal microflora on the susceptibility to endotoxin using a model of germ-free and specific pathogen free mice Detailed record
	Slizniční imunita, střevní mikroflora a nespecifické střevní záněty Tlaskalová, Helena ; Štěpánková, Renata ; Sokol, Dan ; Rossmann, Pavel ; Cukrowska, Božena ; Hudcovic, Tomáš ; Tučková, Ludmila ; Kozáková, Hana ; Řeháková, Zuzana ; Hrnčíř, Tomáš ; Drastich, Pavel ; Frolová, Lenka ; Powrie, F. ; Uhlig, H. ; Bland, P. W. Etiological role of intestinal microflora and abberant function of mucosal immunity in development of inflammatory bowel disease is discussed. Animal models of human IBD are described and characterized Detailed record
	Mucosal immunity, intestinal microflora and inflammatory bowel disease (IBD) Tlaskalová, Helena ; Štěpánková, Renata ; Powrie, F. ; Tučková, Ludmila ; Sokol, Dan ; Funda, David P. ; Rossmann, Pavel ; Cukrowska, Božena ; Hudcovic, Tomáš ; Kozáková, Hana ; Řeháková, Zuzana ; Hrnčíř, Tomáš ; Drastik, p. ; Smetana, K. ; Frolová, Lenka The interface between the organism and the outside world, which is the site of exchange of nutrients. Detailed record

National Repository of Grey Literature : 17 records found   11 - 17  jump to record:

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