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Diseases caused by ionizing radiation and their prevention
Hřib, Zdeněk ; Hrnčíř, Evžen (advisor)
3 SUMMARY The text summarizes some of the newest knowledge about effects of the ionizing radiation on various levels of the biological systems and recent recommendations for radiological protection. First chapter of this diploma work gives a brief definition of ionizing radiation, possible sources, summary of its interactions with matter and description of the dosimetric quantities. Second chapter focuses on biological effects of the ionizing radiation. With development of micro-beam technology, the newest research has finally confirmed the assumption of DNA as the main target cell structure for ionizing radiation damage. Apart from well known stochastic effects (cancerogenic and those, causing hereditary and chronic diseases) caused by non-lethal cell damage and organ and tissue reaction (formerly known as non-stochastic or deterministic effect, eg. acute radiation syndrome, acute local damage, chronic radiodermatitis and cataract) caused by lethal cell damage also issues like low dose threshold, in utero exposure risk and newest recommendations for weighting factors are discussed here. Last chapter is dedicated to targets and principles of radiological protection for patients, workers and other population.
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Diseases caused by ionizing radiation and their prevention
Hřib, Zdeněk ; Hrnčíř, Evžen (advisor)
3 SUMMARY The text summarizes some of the newest knowledge about effects of the ionizing radiation on various levels of the biological systems and recent recommendations for radiological protection. First chapter of this diploma work gives a brief definition of ionizing radiation, possible sources, summary of its interactions with matter and description of the dosimetric quantities. Second chapter focuses on biological effects of the ionizing radiation. With development of micro-beam technology, the newest research has finally confirmed the assumption of DNA as the main target cell structure for ionizing radiation damage. Apart from well known stochastic effects (cancerogenic and those, causing hereditary and chronic diseases) caused by non-lethal cell damage and organ and tissue reaction (formerly known as non-stochastic or deterministic effect, eg. acute radiation syndrome, acute local damage, chronic radiodermatitis and cataract) caused by lethal cell damage also issues like low dose threshold, in utero exposure risk and newest recommendations for weighting factors are discussed here. Last chapter is dedicated to targets and principles of radiological protection for patients, workers and other population.
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The information support of laboratory requisitions in hospitals in the Czech Republic
Fišerová, Marcela ; Stanovská, Iva (advisor) ; Hřib, Zdeněk (referee)
This thesis deals with the information support of laboratory requisitions in medical facilities in the Czech Republic. Its aim is to analyze the usage status of electronic request systems and their integration into hospital systems in practice of Czech medical equipment. Further, on the basis of the survey, the thesis draws conclusions about the overall state and an assumed development of such systems. The analysis was conducted by means of questionnaire survey in a randomly chosen sample of health facilities in the CR. The study results can serve both to the actual respondents who participated in the study for comparison with the competition and to IS / ICT companies for the eventual development of application software systems to support the analyzed area. The work is divided into a theoretical and a practical part. The theoretical part is based on the available research, literature and electronic sources concerning information technology in health care. The practical part deals with the research study - a questionnaire survey, analysis, and interpretation of results.
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Application integration in healthcare domain - Electronic prescription in Czech Republic using HL7 standards
Slavětínský, Václav ; Stanovská, Iva (advisor) ; Hřib, Zdeněk (referee)
This thesis is concerned with electronic prescription of drugs in the Czech republic. The objective is to find a proper standard for electronic medical data exchange and use it for building a new data communication interface for the e-prescription system. This work attends to the evolution and actual situation of the national e-prescription system. The system is based on one central storage for e-prescriptions, however, currently it isn't being used. On basis of valid legislation, electronic prescription and drug dispense processes are analyzed. Furthermore, present central storage data interface is explored. Considering advantages, that are bound to utilization of electronic data exchange standards, main objective of this thesis is given, to design a new interface for transmission of e-prescriptions and drug dispense notifications. New interface shall adhere to standards. Czech standard DASTA and europian norm EN13606 were examined. After all, set of specifications HL7 (Health Level Seven) has been chosen, which suits the requirements best. Data interface design, with HL7 standards, is based on exchange of documents. Documents (prescription, dispense notification) are expressed in the Clinical Document Architecture (CDA) format, and exchanged between applications by means of the Medical Records domain messages. The structure of wrappers, forming a message, results from common HL7 Specification Infrastructure. Presented design has been inspired by Finnish solution eResepti. The design tries to transform present interface of central storage to format, which is defined by selected HL7 specifications. It can be used in both local and central e-prescription systems. It may also support the development of systems for electronic health(care) records exchange.
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