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The influence of birth order on social pathological phenomena and risky behavior
Polienko, Arina ; Kuba, Radim (advisor) ; Daňková, Hana (referee)
This thesis focuses on the influence of birth order on social pathological phenomena and risky behavior. It describes the theory of birth order and emphasizes its evolutionary-biological assumptions. The main goal of the thesis is to summarize existing knowledge about the relationship of birth order with selected socially unacceptable phenomena. It compares the diverse results of scientific studies and assumes possible causal mechanisms of the dynamics observed in them. It points to understudied areas that require further investigation. In these areas, the thesis tries to predict theoretically possible indirect dependence through other factors that are connected with the theory of birth order. It points to the importance for research of such aspects of birth order theory as the age spacing and gender of siblings. This thesis should serve as a theoretical basis for further research of the issue.
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Influence of birth order and sex of siblings on sexual behavior and preferences
Daňková, Hana ; Kuba, Radim (advisor) ; Krejčová, Lucie (referee)
Ontogeny of a human being is influenced by several innate and environmental factors. One of the key environmental factors is family, its structure, and the dynamics of family relationships. These can depend, among other things, on the birth order. Relatively a lot of research has been conducted to study the effect of birth order on humans, but the area of human sexuality is often neglected. Research in this area has so far yielded relatively inconsistent results and needs to be expanded further with new knowledge. That is the main goal of this diploma thesis. In our cross-sectional study, 4495 subjects from two-child families were analyzed. We performed a partial correlation analysis of birth order and selected variables related to human sexuality, considering the sex of siblings. Particular attention was paid to the first sexual experience, the number of sexual partners, sociosexual orientation (SOI-R), and dominant-submissive sexual preferences. We found that the order of birth is related to several of these variables (age of first sexual experience, number of sexual partners, sexual preferences), but the key role is played by the combination of the individual's gender and the sex of his sibling. These results should be followed up by more detailed research within specific families to verify the...
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Characterization of ligand binding to M1 muscarinic acetylcholine receptor using fluorescence anisotropy method
Danková, Hana ; Vokřál, Ivan (advisor) ; Červený, Lukáš (referee)
Charles University Faculty of Pharmacy in Hradec Králové Department of Pharmacology and Toxicology Student: Hana Danková Supervisors: Prof. Ago Rinken, PhD. MSc. Tõnis Laasfeld PharmDr. Ivan Vokřál, PhD. Title of diploma thesis: Characetrization of ligand binding to M1 muscarinic receptor using fluorescence anisotropy method Muscarinic acetylcholine receptors (mAChRs), members of the superfamily of G-protein coupled receptors (GPCRs), regulate vital physiological processes and are important targets in drug research. Five different subtypes (M1 - M5) have been identified. M1 mAChR is mainly distributed in the central nervous system and is linked to pathophysiology of neurodegenerative diseases. In recent years, fluorescent methods have been frequently used in studies of ligand binding to receptors. The fluorescence anisotropy (FA) is a homogenous assay to characterize ligand binding to receptors. In this work, we have evaluated the FA method with fluorescent ligand MK342 binding to M1 mAChRs expressed on budded baculovirus (BBV) particles. The fluorescence ligand was binding with the high affinity (4,4 nM) to M1 receptor in constructed BBV preparation. The apparent binding affinities (pKi) of eleven classical and three bitopic muscarinic ligands were screened and compared to previously published...
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Characterization of ligand binding to M1 muscarinic acetylcholine receptor using fluorescence anisotropy method
Danková, Hana ; Vokřál, Ivan (advisor) ; Červený, Lukáš (referee)
Charles University Faculty of Pharmacy in Hradec Králové Department of Pharmacology and Toxicology Student: Hana Danková Supervisors: Prof. Ago Rinken, PhD. MSc. Tõnis Laasfeld PharmDr. Ivan Vokřál, PhD. Title of diploma thesis: Characetrization of ligand binding to M1 muscarinic receptor using fluorescence anisotropy method Muscarinic acetylcholine receptors (mAChRs), members of the superfamily of G-protein coupled receptors (GPCRs), regulate vital physiological processes and are important targets in drug research. Five different subtypes (M1 - M5) have been identified. M1 mAChR is mainly distributed in the central nervous system and is linked to pathophysiology of neurodegenerative diseases. In recent years, fluorescent methods have been frequently used in studies of ligand binding to receptors. The fluorescence anisotropy (FA) is a homogenous assay to characterize ligand binding to receptors. In this work, we have evaluated the FA method with fluorescent ligand MK342 binding to M1 mAChRs expressed on budded baculovirus (BBV) particles. The fluorescence ligand was binding with the high affinity (4,4 nM) to M1 receptor in constructed BBV preparation. The apparent binding affinities (pKi) of eleven classical and three bitopic muscarinic ligands were screened and compared to previously published...
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Communal House in Litvínov
Daňková, Hana ; Pauknerová, Karolína (advisor) ; Toušek, Ladislav (referee)
7 Abstract This thesis presents the case of the Collective House (Koldům) in Litvínov, Czech Republic in the period of 1945-60. The house with its 352 flats was built between 1947- 1957 by a local chemical factory for its employees, mainly for families with children. House's collective facilities should have made child- and household care easier. Koldům was also supposed to offer colorful social life. I have tried to depict the beginnings of living in Koldům, the use of collective facilities and social life in the house, supported by memories of informants, who settled down in Koldům in the 1950s and have been living there since. The memories of the informants showed, that the newcomers used spaces and facilities of the house according to their lifestyles. Some services, offered to the inhabitants were therefore more successful than others. Considering the high living standards offered in Koldům, the inhabitants perceived living there as very status-important. This has changed a lot until today. Shared images of the past serve as a powerful tool of legitimization for the community of the original inhabitants, amongst them the informants belong, and serve as a tool, by which the difference between the past and the presence is emphasized. In contrast to the past, the presence is perceived as declining,...
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