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Surface phenotype of human carcinoma cancer stem cells (CSC)
Bočková, Marie ; Drbal, Karel (advisor) ; Čermák, Vladimír (referee)
Tumor is composed of a heterogenous mass of cells. Similar to normal healthy organs and tissues, these can be divided into individual cellular subpopulations according to morphology, function and expression patterns. A subpopulation of cells that are able to give rise to all of these cellular lineages is referred to as cancer stem cells (CSC). CSCs have the capabilities of normal stem cells such as the self-renewal and the ability to give rise to a heterogenous population of differentiated cells. Usually, this is the most resistant subpopulation within a tumor, highly non-responsive to therapy. Doing so, they are the cause of residual disease. Characterisation of CSC markers of individual tumor types is beneficial since it enables higher therapy efficacy via targeting this cell population. The -omics approaches to characterisation of the surface proteome bring a broader view into the field when searching for a unique gene signature of specific cancer stem cell types. It has been found that these cells can be identified based on the high expression levels of CD44, CD90 and CD49f. Among other markers, CD47 is an important marker for its immunosuppressive function.
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Surface phenotype of human carcinoma cancer stem cells (CSC)
Bočková, Marie ; Drbal, Karel (advisor) ; Čermák, Vladimír (referee)
Tumor is composed of a heterogenous mass of cells. Similar to normal healthy organs and tissues, these can be divided into individual cellular subpopulations according to morphology, function and expression patterns. A subpopulation of cells that are able to give rise to all of these cellular lineages is referred to as cancer stem cells (CSC). CSCs have the capabilities of normal stem cells such as the self-renewal and the ability to give rise to a heterogenous population of differentiated cells. Usually, this is the most resistant subpopulation within a tumor, highly non-responsive to therapy. Doing so, they are the cause of residual disease. Characterisation of CSC markers of individual tumor types is beneficial since it enables higher therapy efficacy via targeting this cell population. The -omics approaches to characterisation of the surface proteome bring a broader view into the field when searching for a unique gene signature of specific cancer stem cell types. It has been found that these cells can be identified based on the high expression levels of CD44, CD90 and CD49f. Among other markers, CD47 is an important marker for its immunosuppressive function.
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Offer of liability insurance on Czech market
Bočková, Marie ; Radová, Jarmila (advisor)
This barchelor thesis deals with an offer of liability insurance on Czech market. The first part is focused on general definition of the damage liability and basic concepts related to it, history and legislation. The second part describes the current situation in lability insurance on Czech insurance market. The third part is focused on the description of products offered by insurance companies from Czech republic. The last part is focused on comparision of the premiums for severl model cases.
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Management of receivables and its reflection in the accounting firm
Adámková, Hana ; Šiška, Ladislav (advisor) ; Bočková, Marie (referee)
This dissertation is focused on the analysis of the current method of proceeding REC incl. its effect on accounting firm and to draw up its own credit management. Theoretical part of the dissertation offers information and receivables management concepts, their prevention, and debt collection. This part describes the meaning and usability tools of collection activity. The starting point for setting up a new system is the assessment of the financial situation of the company with financial analysis and analysis of the current state of the receivables. The practical part also includes the elaboration of proposals and recommendations, and the application of specific methods, incl. the costs and benefits. The result of the dissertation is effective system solutions to the outstanding receivables.
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