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Study of disintegration time of capsules containing liquisolid systems
Bartůňková, Denisa ; Vraníková, Barbora (advisor) ; Svačinová, Petra (referee)
Charles University in Prague, Faculty of Pharmacy in Hradec Králové Department of: Pharmaceutical Technology Supervisor: doc. PharmDr. Barbora Vraníková, Ph.D. Consultant: MSc. Andreas Niederquell Candidate: Denisa Bartůňková Title of Diploma Thesis: Study of disintegration time of capsules containing liquisolid systems Liquisolid (LS) systems are free-flowing powder formed by dispersing a drug that is sorbed into a carrier. The resulting powder may be subsequently processed into the final dosage form (tablet, hard gelatine capsules and pellets). However, there is a risk of interactions between the solvent used and the capsule shell, which could affect its rate of disintegration. Therefore, this study is focused on the preparation of liquisolid capsules (LSC) and the evaluation of their disintegration rate in various media. Tested LSC contained pure solvents (polyethylene glycol 200 - PEG 200, polyethylene glycol 400 - PEG 400 or Transcutol ® HP - T-HP) or dispersion of cyclosporine A (cysA) in the above-mentioned solvents sorbed into a carrier material Neusilin® US2 (NUS2). The evaluation of LSS showed that LSC have a longer disintegration time compared to capsules containing only NUS2. However, LSC with both types of PEGs disintegrated more slowly than those with T-HP. Moreover, different...
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Media Image of the Selected Geological Terms from Evolution of the Organisms on the Earth
Bartůňková, Denisa ; Teodoridis, Vasilis (advisor) ; Říhová, Dagmar (referee)
1 ABSTRACT The aim of the presented bachelor thesis is to map the media image of 9 selected geological terms related to the topic "Evolution of the Organisms on the Earth" and to analyse an educational potential of selected media texts/articles for teaching process at primary and secondary schools. The bachelor thesis also presents the author's methodology for evaluation of the occurrence and categorization of (geological) terms in media texts/articles selected using the Anopress database. The thesis combinates qualitative content analysis and qualitative research. The research sample includes 115 articles/texts from the 15 most read news websites from the first to third quarters in 2021. The results show that (i) the most frequently mentioned topics in media are recent organisms, geological environment and ecological terms and relationships in a context of the analysed geological terms, (ii) only a small percentage of the analysed articles/texts can be used for teaching process at primary and secondary schools as supplementary studied materials, because most of the articles have mentioned geological terms without further explanation, (iii) Deník.cz has the highest educational potential from the 15 most read news websites. KEYWORDS Media, terms, geology, teaching, primary school, secondary school,...
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