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Drug Information Centre service analysis VI. - drug enquires on social media
Dražanová, Magdaléna ; Malá, Kateřina (advisor) ; Ťupová, Lenka (referee)
Drug Information Centre service analysis VI. Author: Magdaléna Dražanová Supervisor: PharmDr. Kateřina Malá, Ph.D. Consultant: PharmDr. Petra Rozsívalová Department of Social and Clinical Pharmacy, Faculty of Pharmacy in Hradec Králové, Charles University, Czech Republic Introduction and aim: The Facebook website related to Mladí lékárníci, z. s., association was founded in 2010 and offers, among others, space for discussion of drug-related queries. The Drug Information Center (DIC) of the Faculty of Pharmacy in Hradec Králové, Charles University, and the University Hospital Hradec Králové (FaF UK and FN HK) was founded in 1994 and its main activity is the processing of drug enquiries from healthcare professionals. The aim of the thesis was to analyze the functioning of the Facebook website with a focus on drug-related queries and its comparison with DIC FaF UK and FN HK in 2021 and 2022. Methods: The posts with drug-related topics were separated from the other posts within the Facebook website. They were anonymized and sorted by the date of their publishing. Then, they were numbered according to the focus of the query and the group of the patient population. The categorization was created based on the DIC FaF UK and FN HK system. Special attention was paid to the covid-19, the so-called Ukrainian...
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Analysis of adherence to application technique in COPD patients
Jachanová, Klára ; Hendrychová, Tereza (advisor) ; Ťupová, Lenka (referee)
Analysis of adherence to application technique in COPD patients Author: Klára Jachanová Tutor: PharmDr. Tereza Hendrychová, Ph.D. Consultant: doc. PharmDr. Josef Malý, Ph.D. Department of Social and Clinical Pharmacy, Faculty of Pharmacy in Hradec Králové, Charles University Introduction and aims: Adherence is an sssential component of patient care and is also important for achieving treatment goals. Poor adherence leads to increased morbidity, mortality and healthcare expenditures. The aim of this study was to analyze adherence to application technique in patients with chronic obstructive pulmonary disease (COPD), taking into account inhaler device and patient characteristics. Methods: The Czech Multicenter Research Database of COPD, non-interventional observational prospective study, was used as a source of clinical data. Adherence to the application technique was evaluated using Five Steps Assessment. Patients were recruited to the study from August 2013 to December 2016 by 14 outpatient secondary health care centers providing respiratory physician- based care to patients with COPD throughout the Czech Republic. Each of the five consecutive steps was evaluated by a trained healthcare professional. The study evaluated dry powder inhaler and pressurised matered-dose inhaler. Physical and...
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Analysis of the provision of consultancy during the dispensing of selected medicinal products by non-medical staff.
Šmigurová, Alica ; Ťupová, Lenka (advisor) ; Hendrychová, Tereza (referee)
Charles University, Faculty of Pharmacy in Hradec Králové Department of Social and Clincal Pharmacy Student Alica Šmigurová Supervisor PharmDr. Lenka Ťupová, Ph.D. Title of thesis Analysis of the provision of consultancy during the dispensing of selected medicinal products by non medical staff Introduction: Selected medicinal products are medicinal products that are available outside of pharmacy. They can be often obtained in supermarkets and petrol stations. Objectives: The main goal of this research was to analyse the real situation in the stores selling SMP, according to good practise and the provision of consultancy during the selling of SMP by staff in Hradec Králové and its near surrounding. The purpose was extended to finding the availability and selling of SMP in Czech Republic. Methods: The practical part consisted of two phases. In the first phase, two anonymous visits were done. The first visit went on without asking staff. During the second visit the staff was asked for advice. The second phase consisted of an online questionnaire about demand, availability and saleability of SMP. In total, 2632 retailers were asked about took part in it. Results: In the most cases from 28 ones (89 %) SMP were stored free in selling area, in 3 stores (11%) VLP were in a locked cabinet. All stores had...
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Drug Information Centre service analysis VI. - drug enquires on social media
Dražanová, Magdaléna ; Malá, Kateřina (advisor) ; Ťupová, Lenka (referee)
Drug Information Centre service analysis VI. Author: Magdaléna Dražanová Supervisor: PharmDr. Kateřina Malá, Ph.D. Consultant: PharmDr. Petra Rozsívalová Department of Social and Clinical Pharmacy, Faculty of Pharmacy in Hradec Králové, Charles University, Czech Republic Introduction and aim: The Facebook website related to Mladí lékárníci, z. s., association was founded in 2010 and offers, among others, space for discussion of drug-related queries. The Drug Information Center (DIC) of the Faculty of Pharmacy in Hradec Králové, Charles University, and the University Hospital Hradec Králové (FaF UK and FN HK) was founded in 1994 and its main activity is the processing of drug enquiries from healthcare professionals. The aim of the thesis was to analyze the functioning of the Facebook website with a focus on drug-related queries and its comparison with DIC FaF UK and FN HK in 2021 and 2022. Methods: The posts with drug-related topics were separated from the other posts within the Facebook website. They were anonymized and sorted by the date of their publishing. Then, they were numbered according to the focus of the query and the group of the patient population. The categorization was created based on the DIC FaF UK and FN HK system. Special attention was paid to the covid-19, the so-called Ukrainian...
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Oral Contraceptive Consumption in the Czech Republic
Zahradniková, Barbara ; Ťupová, Lenka (advisor) ; Dvořáčková, Simona (referee)
Title: Oral Contraceptive Consumption in the Czech Republic Author: Barbara Zahradniková, DiS. Supervisor: PharmDr. Lenka Ťupová, Ph.D. Introduction: Hormonal contraception is a group of drugs used to prevent pregnancy. In addition, it is also used in the number of other indications, such as reducing the manifestations of acne vulgaris, reducing heavy menstrual bleeding, regulating the menstrual cycle or relieving premenstrual symptoms. Objective: The aim of the diploma thesis was to analyse and evaluate the consumption of all types of hormonal contraception in the Czech Republic in the period from 2008 to 2022 using data obtained from the database of the State Institute for Drug Control (SIDC). Methods: A retrospective consumption analysis was used for the evaluation. Consumption was evaluated based on the number of packages delivered to healthcare facilities in the period between 2008-2022. The obtained data were classified according to individual ATC codes and then compared according to established parameters, e.g. type of evaluated hormonal contraception or dosage form. Results: During the monitored period, the consumption of combined contraception clearly dominated (89,62 %) over the progestagen type of contraception (10,38 %). In the case of combined hormonal contraception, the largest part...
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Current role of veterinary drugs in pharmacy
Galambicová, Eliška ; Vokřál, Ivan (advisor) ; Ťupová, Lenka (referee)
Charles University Faculty of Pharmacy in Hradec Králové Department of Pharmacology & Toxicology Student: Eliška Galambicová Supervisor: PharmDr. Ivan Vokřál, Ph.D. Title of diploma thesis: Current role of veterinary drugs in pharmacy The aim of this diploma thesis is to chart the current role of veterinary drugs in the range of pharmacies and the knowledge of pharmacists in the field of veterinary drugs. Data was collected via questionnaire from March to May 2021 and the target group was graduates in the field of pharmacy. A total of 2,148 pharmacies across the Czech Republic were contacted via an e-mail obtained from the website of the State Institute of Drug Control. The anonymous questionnaire consisted of a total of 15 questions which focused on mass-produced veterinary medicinal products and individually prepared veterinary medicinal products, human drugs used in veterinary care, a background of knowledge of pharmacists in the field and information that pharmacists consider important which was not acquired throughout their studies. A total of 325 completed questionnaires were obtained within the survey, while the array of pharmacies that completed the questionnaire was approximately even throughout the Czech Republic. The results showed that 92.3 % of the surveyed pharmacies across the Czech...
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Analysis of drug administration by nurses in health facility V
Parasotska, Yuliia ; Doseděl, Martin (advisor) ; Ťupová, Lenka (referee)
Analysis of drug administration by nurses in health facility V Author: Yuliia Parasotska Tutor: PharmDr. Martin Doseděl, Ph.D. Department of Social and Clinical Pharmacy, Faculty of Pharmacy in Hradec Králové, Charles University Introduction: Medication errors in the healthcare setting affect patients in terms of morbidity, mortality, medication side-effects and longer hospital stays. For this reason, the analysis and detection of medication problems make a significant contribution to improving patient care and increasing patient safety. Objective: To describe and analyse the most common medication problems encountered in a healthcare facility during administration of medication by a nurse. Methodology: A prospective multicentre observational study was conducted in July 2021 in a hospital in the South Bohemian region. Using the direct observation method, medication errors occurring during medication dispensing by a nurse were monitored in three wards of the hospital. Over six days, the research team collected data from selected hospital wards and entered them into an online database to further assess the problems encountered and prevention measures were developed using descriptive statistics. Results: During the study, 13 nurses administered a total of 1,544 medications to 82 patients in three...
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Antidepressant (SARI, NDRI, RIMA) Consumption in Czech Republic
Bucková, Veronika ; Horký, Pavel (advisor) ; Ťupová, Lenka (referee)
Antidepressant (SARI, NDRI, RIMA) Consumption in Czech Republic Charles University Faculty of Pharmacy in Hradec Králové Department of Social and Clinical Pharmacy Author: Veronika Bucková Supervisor: PharmDr. Pavel Horký, Ph.D. Antidepressants are drugs used mainly to treat pathologically low mood and anxiety disorders. The antidepressants focused in this work from the SARI, NDRI and RIMA groups are also used in the treatment of insomnia, smoking cessation, as support in weight reduction and in some psychogenic sexual dysfunctions. The goal of this work is to analyze the consumption of antidepressants from the SARI, NDRI and RIMA groups in Czech Republic. The data for this work were obtained from the database of the State Institute for Drug Control on the basis of mandatory reporting of the volume of drugs supplied by distributors to pharmacies and other medical facilities. Consumption was monitored in the period from 1.1.2008 to 31.12.2020. The DUR type methodology was used and consumption was expressed in the number of defined daily doses per thousand inhabitants per day (DID). The results confirm the rising trend of antidepressant consumption only in the case of trazodone (SARI), whose consumption increased 3.8 times compared to 2008. The reason for this growth is the use of trazodone as an...
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Interactions of selected antiretroviral drugs and methylmercury with placental membrane transporters
Ťupová, Lenka ; Čečková, Martina (advisor) ; Fusek, Josef (referee) ; Kacerovský, Marian (referee)
Charles University, Faculty of Pharmacy in Hradec Králové Department of Pharmacology and Toxicology Candidate: Mgr. Lenka Ťupová Supervisor: doc. PharmDr. Martina Čečková, Ph.D. Title of doctoral thesis: Interactions of selected antiretroviral drugs and methylmercury with placental membrane transporters. Pregnant women are especially in developed countries exposed to high amount of various xenobiotic including environmental pollutants and drugs. Antiretroviral therapy (ART) is administered to HIV positive pregnant women for the purpose of prevention of HIV mother- to-child-transmission. Pharmacokinetics of many antiretrovirals is limited or enhanced by activity of ATP-binding cassette (ABC) or Solute carrier's transporters, of which many are expressed also in placental tissue. ART therapy usually consists of combination of 3 - 4 antiretroviral drugs, thereby leading to higher risk for development of drug-drug interactions on ABC and SLC transporters. In this study we described influence of non-nucleoside reverse transcriptase inhibitors etravirin and rilpivirin on BCRP- and MDR1-mediated transport of tenofovir disoproxil fumarate (TDF) and/or abacavir. Etravirin showed potent inhibition of BCRP transporter significantly changing transport of both, TDF and abacavir, across monolayers of MDCKII-BCRP...
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Interactions of selected antiretroviral drugs and methylmercury with placental membrane transporters
Ťupová, Lenka ; Čečková, Martina (advisor) ; Fusek, Josef (referee) ; Kacerovský, Marian (referee)
Charles University, Faculty of Pharmacy in Hradec Králové Department of Pharmacology and Toxicology Candidate: Mgr. Lenka Ťupová Supervisor: doc. PharmDr. Martina Čečková, Ph.D. Title of doctoral thesis: Interactions of selected antiretroviral drugs and methylmercury with placental membrane transporters. Pregnant women are especially in developed countries exposed to high amount of various xenobiotic including environmental pollutants and drugs. Antiretroviral therapy (ART) is administered to HIV positive pregnant women for the purpose of prevention of HIV mother- to-child-transmission. Pharmacokinetics of many antiretrovirals is limited or enhanced by activity of ATP-binding cassette (ABC) or Solute carrier's transporters, of which many are expressed also in placental tissue. ART therapy usually consists of combination of 3 - 4 antiretroviral drugs, thereby leading to higher risk for development of drug-drug interactions on ABC and SLC transporters. In this study we described influence of non-nucleoside reverse transcriptase inhibitors etravirin and rilpivirin on BCRP- and MDR1-mediated transport of tenofovir disoproxil fumarate (TDF) and/or abacavir. Etravirin showed potent inhibition of BCRP transporter significantly changing transport of both, TDF and abacavir, across monolayers of MDCKII-BCRP...
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