|
|
Gregor Piatigorsky
Špaček, Petr ; PETRÁŠ, Miroslav (advisor) ; STRAŠIL, Tomáš (referee)
In this Master disertation, the author talks about the life and career of a legendary virtuoso cellist Gregor Piatigorsky. Gregor Piatigorsky is one of the most important figures in the history of cello. Piatigorsky has not only achieved an incredible solo career, but as a teacher he also raised a large number of great cellists and cello teachers of today. Among his most famous pupil are Mischa Maisky, Steven Isserlis or Raphael Wallfish. Disertation also includes authors own experience with teaching of Laurence Lesser, who was an assistant of Piatigorsky for almost 7 years, and whose style of teaching is nearly the same as Piatigorsky's.
|
|
|
Dukovany nuclear power station. Seismotectonic model. Geological and paleoseismic survey. Sectio A – Assesment of the Diendorf-Boskovice fault zone
Špaček, P. ; Roštínský, Pavel ; Prachař, I. ; Švancara, J. ; Valenta, J. ; Tábořík, P.
Synthesis of geological (structural, tectonic, sedimentological), geophysical (gravimetric, geomagnetic) and geomorphological (topographic arrangement, surface inclination, topolineaments, fluvial system, segmentation of the area along the fault) knowledge on the major fault of the Diendorf-Boskovice tectonic zone. Existing data were completed with a new direct field research (ground geophysics – ERT, borehole survey, study of outcrops and geomorphological conditions along the major fault). The study was elaborated requested by ČEZ corporation (main Czech energetic producer) in connection with the assessment of seismic hazard to the near Dukovany nuclear power station related both to a renewal of working license of existing facilities (two production units) and to a planned extension of energetic system by a third production installation. It was especially focused on the nearest fault section Tetčice – Hostěradice in the Czech Republic. In the closing section, a rate of potential Upper Quaternary tectonic activity related to evidenced geotectonically active period of Lower Miocene were evaluated. The report will serve as a basic source for a compilation of seismic model of the Diendorf-Boskovice zone.
|
|
|
Acyclic nucleoside bis-phosphonates as potent inhibitors of 6-oxopurine phosphoribosyltransferases
Špaček, Petr ; Keough, D. T. ; Vrbková, Silvie ; Slavětínská, Lenka ; Janeba, Zlatko ; Naesens, L. ; Edstein, M. D. ; Chavchich, M. ; Wang, T. H. ; de Jersey, J. ; Guddat, L. W. ; Hocková, Dana
Hypoxanthine-guanin-(xanthine) phosphoribosyltransferase (HG(X)PRT) is critical for the survival of malarial parasites Plasmodium falciparum and Plasmodium vivax. These parasites rely on HG(X)PRT to make 6-oxopurine nucleoside monophosphates. Specific acyclic nucleoside phosphonates (ANPs) inhibit HG(X)PRT and thus have an anti-plasmodial activity. Crystal structures of human HGPRT in complex with several ANP-based inhibitors suggested that attachment of the second phosphonate group which could occupy the pyrophosphate binding site may lead to increased affinity of these compounds.
|
|
|
Acyclic nucleoside bisphosphonates as inhibitors of 6-oxopurine phosphoribosyltransferases: Potential antimalarial and antibacterial agents
Hocková, Dana ; Keough, D. T. ; Špaček, Petr ; Janeba, Zlatko ; Edstein, M. D. ; Chavchich, M. ; Wang, T. H. ; Eng, W. S. ; West, N. P. ; de Jersey, J. ; Guddat, L. W.
Acyclic nucleoside phosphonates (ANPs) that contain a 6-oxopurine base are good inhibitors of the human, Plasmodium falciparum, P. vivax, Escherichia coli and Mycobacterium tuberculosis 6-oxopurine phosphoribosyltransferases (PRTases), key enzymes of the purine salvage pathway. Chemical modifications based on the crystal structures of several inhibitors in complex with human HGPRTase have led to the design of new ANPs. These novel compounds contain a second phosphonate group attached to the ANP scaff old. The crystal structures of these inhibitors in complex with human HGPRTase show that they can fill three critical locations in the active site: the binding sites of the purine base, the 5’-phosphate group and pyrophosphate. Prodrugs have been synthesized and have been shown to arrest the growth of P. falciparum in erythrocyte culture. Prodrugs of selected ANPs also inhibit the growth of Mycobacterium tuberculosis in cell-based assays.
|
|
| |
|
|
SLICE Seismic lithospheric investigation of Central Europe
Akademie věd ČR, Geofyzikální ústav, Praha ; Uličný, David ; Růžek, Bohuslav ; Hubatka, František ; Špaček, Petr ; Švancara, Jan ; Brož, Milan ; Novotný, Miloslav ; Karousová, Olina ; Hrubcová, Pavla ; Špičák, Aleš ; Novotný, Miroslav
Projekt SLICE má za úkol zkoumat hlubinnou stavbu středoevropské oblasti a jeho cílem je přispět k výzkumu stavby zemské kůry a svrchního pláště v oblasti Českého masivu a jeho styku se sousedními tektonickými jednotkami. Pro studium hlubinné stavby je využívána seismická refrakční metoda, kdy se registrují seismické vlny generované uměle vyvolanými odpaly a posléze je zjišťována rychlost šíření seismických vln v různých hloubkách. Tyto údaje pak zprostředkovaně poskytnou informace o strukturních vlastnostech měřeného prostředí až do oblasti svrchního pláště. Je popsáno propojení refrakčních experimentů ALP 2002 a SUDETES 2003 na našem území.
|
|
|
SLICE Seismic lithospheric investigation of Central Europe
Akademie věd ČR, Geofyzikální ústav, Praha ; Špaček, Petr ; Švancara, Jan ; Brož, Milan ; Novotný, Miloslav ; Karousová, Olina ; Hrubcová, Pavla ; Špičák, Aleš ; Novotný, Miroslav
Projekt SLICE má za úkol zkoumat hlubinnou stavbu středoevropské oblasti a jeho cílem je přispět k výzkumu stavby zemské kůry a svrchního pláště v oblasti Českého masivu a jeho styku se sousedními tektonickými jednotkami. Pro studium hlubinné stavby je využívána seismická refrakční metoda, kdy se registrují seismické vlny generované uměle vyvolanými odpaly a posléze je zjišťována rychlost šíření seismických vln v různých hloubkách. Tyto údaje pak zprostředkovaně poskytnou informace o strukturních vlastnostech měřeného prostředí až do oblasti svrchního pláště. Je popsáno propojení refrakčních experimentů ALP 2002 a SUDETES 2003 na našem území.
|
|
| |
|
|
Efficient one-pot synthesis of polysubstituted 6-[(1H-1,2,3-triazol-1-yl)methyl]uracils through the "click" protocol
Jansa, Petr ; Špaček, Petr ; Holý, Antonín ; Votruba, Ivan ; Janeba, Zlatko
Synthesis of triazoloacyclic nucleosides and nucleoside phosphonates was developed as the one-pot Cu(I)-catalyzed azide alkyne Huisgen "click" cycloaddition. A novel Cu(I)-catalyzed decarboxylation reaction of 1-substituted 1H-1,2,3-triazole-4-carboxylates at room temperature was observed and used for the preparation of 1-substituted 1H-1,2,3-triazoles.
|
|
| |
guest ::
RSS feed.