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The effect of progesteron administration on T regulatory cells in relation to preterm deliveries
Škvorová, Anna ; Hrdý, Jiří (advisor) ; Krulová, Magdaléna (referee)
During pregnancy, the maternal organism has to cope with the presence of foreign paternal antigens, allow and support the development of a semialogenic fetus, while maintaining its defense against pathogens. This condition is achieved by a dynamic balance of complex immuno-endocrine interactions. A number of cells with specific properties contributes to the tolerogenic setting during pregnancy. Very important role plays the population of T regulatory lymphocytes (Treg). Treg levels increase physiologically during pregnancy and their decline is associated with term and preterm labor. Premature birth is a serious socio-economic problem, affecting around 10 % of births worldwide. In the case of increased risk of premature labor, progesterone administration has been successfully used in clinical practice. One hypothesis says that progesterone induces an increase in Treg population and delays premature labor in this way. The aim of the thesis was to monitor the effect of progesterone therapy in vivo on the amount and functional properties of CD4+ CD25+ FoxP3+ Helios+/- Treg and to verify whether long-term vaginal administration of progesterone positively correlates with an increase in Treg counts. Another goal was to determine whether progesterone promotes Treg generation and the production of...
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The effect of progesteron administration on T regulatory cells in relation to preterm deliveries
Škvorová, Anna ; Hrdý, Jiří (advisor) ; Krulová, Magdaléna (referee)
During pregnancy, the maternal organism has to cope with the presence of foreign paternal antigens, allow and support the development of a semialogenic fetus, while maintaining its defense against pathogens. This condition is achieved by a dynamic balance of complex immuno-endocrine interactions. A number of cells with specific properties contributes to the tolerogenic setting during pregnancy. Very important role plays the population of T regulatory lymphocytes (Treg). Treg levels increase physiologically during pregnancy and their decline is associated with term and preterm labor. Premature birth is a serious socio-economic problem, affecting around 10 % of births worldwide. In the case of increased risk of premature labor, progesterone administration has been successfully used in clinical practice. One hypothesis says that progesterone induces an increase in Treg population and delays premature labor in this way. The aim of the thesis was to monitor the effect of progesterone therapy in vivo on the amount and functional properties of CD4+ CD25+ FoxP3+ Helios+/- Treg and to verify whether long-term vaginal administration of progesterone positively correlates with an increase in Treg counts. Another goal was to determine whether progesterone promotes Treg generation and the production of...
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Progesterone influence on the maternal immune system in pregnancy
Škvorová, Anna ; Koucký, Michal (advisor) ; Černý, Jan (referee)
Pregnancy represents a major challenge to the maternal immune system. From an immunological point of view, a fetus is a semi-allograft. The mechanisms providing immunological paradox of fetal tolerance are still not well known and require further research. A complex network of immuno-endocrine interactions ensures fetal growth and development within the maternal uterus. The hormone playing an indispensable role in pregnancy is progesterone. The aim of this thesis is to summarize current knowledge of the effects of progesterone on the immune system in pregnancy and its mechanisms. Progesterone can affect target cells via the classical nuclear progesterone receptors, which act as transcription factors, or it can act using a variety of other ways, including non-genomic rapid signaling. Progesterone optimizes conditions for successful establishment and maintenance of pregnancy, changes the amount, localization and characteristics of immune cells and production of cytokines. It reduces the antigen-presenting capacity of dendritic cells, monocytes, and macrophages, suppresses NK cell cytotoxicity, supports the proliferation of uterine NK and dendritic cells, affects B cells and induces the formation of T regulatory cells and their recruitment into the fetal-maternal interface. The wide range of...
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