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Histological image of healthy liver and comparison with liver steatosis and cirrhosis.
Čulíková, KIára ; Svobodová, Zuzana (advisor) ; Němečková, Ivana (referee)
The liver is a very important parenchymatous organ for humans. Their function can be impaired by various influences. Common noxins include hepatotropic viruses and other microorganisms, alcohol and other toxins, including drugs, metabolic disorders, biliary obstruction, tumors, genetic abnormalities, and others. The work focuses on the comparison of histological images and clinical diagnosis of healthy individuals with steatosis and cirrhosis. The theoretical part describes the anatomy, physiology and histology of the liver with the perihepatic area. The next chapters focus on the clinic of steatosis and cirrhosis. The practical part describes the procedures for the preparation of healthy and affected liver preparations, as well as the histological methods used for staining individual cell structures. The result of comparing diagnoses of histological specimens and clinical diagnoses of individuals is 94.23 % agreement. Although the found discrepancy of diagnoses is small (5.77 %), it is a reason to think about the development and use of new or modified methods, including the creation of various calculators, including clinical data. Key words: histology, liver, steatosis, cirrhosis
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