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Multimarker Approach in Diagnosis of Cardiovascular Diseases with using Protein Biochips
Vašatová, Martina ; Tichý, Miloš (advisor) ; Gregor, Jaroslav (referee) ; Jabor, Antonín (referee)
Charles University in Prague, Faculty of Pharmacy in Hradec Kralove Department of Biochemical Sciences Candidate: RNDr. Martina Vasatova Supervisor: prof. RNDr. Milos Tichy, CSc. Title of Doctoral Thesis: Multimarker approach in diagnosis of cardiovascular diseases with using protein biochips Background: Measurement of biochemical markers of myocardial injury plays an important role in the diagnosis of cardiovascular disseases. Increase in some cardiac biomarkers is one of main diagnostic standard in acute myocardial infarction (AIM) with or without ST elevation (STEMI, NSTEMI). Recently, the European Society of Cardiology, the American College of Cardiology Foundation, the American Heart Association, and the World Heart Federation have published a consensus definition of myocardial infarction (AIM) that includes a detailed guideline for the assessment of biochemical markers in suspected AIM. The principal markers recommended in this setting include cardiac troponins (cTnI and cTnT) as markers of myocardial necrosis and myoglobin (MYO) and creatine kinase MB isoenzyme (CK-MB mass) quantification in the diagnosis of reinfarction. Excluding acute coronary syndromes, myocardial injury may be found in patients with the other cardiovascular diseases, during therapeutic procedures and operations (e.g....
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Multimarker Approach in Diagnosis of Cardiovascular Diseases with using Protein Biochips
Vašatová, Martina ; Tichý, Miloš (advisor) ; Gregor, Jaroslav (referee) ; Jabor, Antonín (referee)
Charles University in Prague, Faculty of Pharmacy in Hradec Kralove Department of Biochemical Sciences Candidate: RNDr. Martina Vasatova Supervisor: prof. RNDr. Milos Tichy, CSc. Title of Doctoral Thesis: Multimarker approach in diagnosis of cardiovascular diseases with using protein biochips Background: Measurement of biochemical markers of myocardial injury plays an important role in the diagnosis of cardiovascular disseases. Increase in some cardiac biomarkers is one of main diagnostic standard in acute myocardial infarction (AIM) with or without ST elevation (STEMI, NSTEMI). Recently, the European Society of Cardiology, the American College of Cardiology Foundation, the American Heart Association, and the World Heart Federation have published a consensus definition of myocardial infarction (AIM) that includes a detailed guideline for the assessment of biochemical markers in suspected AIM. The principal markers recommended in this setting include cardiac troponins (cTnI and cTnT) as markers of myocardial necrosis and myoglobin (MYO) and creatine kinase MB isoenzyme (CK-MB mass) quantification in the diagnosis of reinfarction. Excluding acute coronary syndromes, myocardial injury may be found in patients with the other cardiovascular diseases, during therapeutic procedures and operations (e.g....
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