National Repository of Grey Literature 248 records found  1 - 10nextend  jump to record: Search took 0.01 seconds. 
Mitochondrion of Trimastix pyriformis
Novák, Lukáš ; Hampl, Vladimír (advisor) ; Kolísko, Martin (referee)
2013 DIPLOMOVÁ PRÁCE Lukáš Novák Abstract Free-living microaerophilic protist Trimastix pyriformis is closely related to oxymonads which are the largest eukaryotic group without any known mitochondrion. In contrast to oxymonads, an enigmatic reduced mitochondrion has been found in the cell of T. pyriformis. In EST data of T. pyriformis, a number of genes has been identified whose products are putatively localized in the mitochondrion. Among these are genes for all the components of the glycine cleavage system, [FeFe]hydrogenases and the mitochondrial marker Cpn60. We performed experiments in order to determine the cellular localization of these proteins. Our results show that the glycine cleavage system is localized in the mitochondrion. Results of the experiments carried out in order to localize two hydrogenases suggest also the mitochondrial localization but are not fully convincing. The attempt to localize Cpn60 has failed. We have also identified a set of new genes in transcripts of T. pyriformis and Monocercomonoides sp. (Oxymonadida). These genes code for some components of the SUF system of FeS cluster synthesis and a peroxidase rubrerythrin. Key words: Trimastix, Monocercomonoides, mitochondrion, hydrogenosome, mitosome, hydrogenase, glycine cleavage system, SUF system.
Place of free will in Leibniz's Philosophy
Formánek, Jakub ; Kranát, Jan (advisor) ; Šprunk, Karel (referee) ; Novák, Lukáš (referee)
3 Bibliografická citace Místo svobodné volby v Leibnizově filosofii [rukopis] : disertační práce / Jakub Formánek ; vedoucí práce: Jan Kranát. -- Praha, 2014. -- 258 s. Anotace Práce se snaží diachronně popsat, jaké místo má svobodná volba v Leibnizově filosofii. Zasazuje Leibnizův výměr svobody do západní diskuze o svobodné volbě. Ukazuje, že významným Leibnizovým part- nerem ve filosofickém myšlení ohledně svobodné volby je barokní scho- lastika. V práci se tvrdí: Leibniz se snaží oslabit jakýkoli striktní deter- minismus či kauzalitu vedoucí k nutnosti, aby svobodná volba měla své reálné zasazení v jeho systému (nebyla jen zdánlivá). Ukazuje, že určitá forma determinismu ještě nemusí vést ke zrušení svobodné volby. Přes všechny snahy je Leibnizův pojem svobodné volby oslaben díky jeho filosofickému teismu. Klíčová slova: Svoboda volby, spontaneita, rozum, kontingence, úplný pojem, jednoduchá substance, monáda, možné světy. Summary In my thesis I describe a place of free will in Leibniz philosophy by the diachronic way. Leibniz sets his concept of free choice into western tra- dition. Important partner to him is Baroque scholastics. Leibniz seeks a place for the free choice within his system throughout his philosophical development. My thesis suggests that Leibniz tries to allay any kind of rigorous...
"Eastern theodicea" as an alternative treatment for the Western problem of evil
Šestáková Novotná, Kateřina ; Novák, Lukáš (advisor) ; Holba, Jiří (referee)
This essay responds to the dissatisfaction of some philosophers with traditional Western solutions to the problem of evil in religion and it offers an alternative solution, which is inspired by the Eastern philosophy of advaita to a great extent. According to the critics, traditional theodicies do not solve the following aspects of the problem of evil: problems with the extent and distribution of evil, suffering of animals and eternal damnation. Three elements of the Eastern philosophy combined with some traditional strategies do solve these problems. The first element is the idea of universal salvation, the second is the theory of karma nand reincarnation and the last one is advaita and lila. These elements can be accepted in various forms and combinations, some of which are more compatible with the traditional methods than others. The final solution is hypothetical and should be understood as a sketech of several ways in which the problem of evil can be solved. This essay is not merely an application of Eeastern concepts to a Western problem, but rather a mutual interaction. That is why I do not hesitate to work with Western new age literature and use Eastern concepts creatively myself. Even though my solution is based on the Indian philospohy of advaita, I criticize its usual implication, according to...
Richard Swinburne and the existence of God: contemporary analytic philosophy of religion
Kočnar, Ondřej ; Sousedík, Stanislav (advisor) ; Novák, Lukáš (referee)
In the first place this thesis is an analysis of the work by R. Swinburne The Existence of God. It introduces the reader into problems with which Swinburne is concerned here - that is the probability of the hypothesis of God's existence. The topic is viewed from a perspective which is close to contemporary Thomism.
The contribution to the knowledge of chipped stone industry in the district of Cheb
Novák, Lukáš ; Popelka, Miroslav (advisor) ; Burgert, Pavel (referee)
The aim of the bachelor thesis is to summarize the existing knowledge of the chipped-stone artifacts in the district of Cheb. The thesis provides a revision of a collection of findings located in Cheb museum, localisation and the manner of acquisition of the findings. The revised artifacts are mostly examined from the typological and material viewpoint. Certain selected localities are revised by the archeological non-destructive research through the method of surface prospecting. The same method is then applied on the newly predicted localities.
The Role of Empathy in Ethical Behaviour
Novák, Lukáš ; Matějek, Jaromír (advisor) ; Ovečka, Libor (referee)
More than two hundred years ago David Hume together with his fellow philosopher Adam Smith posited, that ethical behaviour arises from so called: "moral sense". In the other words, they share the same idea, that passions are principle evoking and guiding human behaviour. Hume claim: "Reason is, and ought only to be the slave of the passions" (…). It is possible that this statement - among others - woke up from the 'dogmatic dream' one of the greatest philosophers of all time - Immanuel Kant, who propose, - contrary to Hume - that reason but not necessary passions can determinate human actions. In the question of what rule the passions in ethics have, it seems to be helpful to use the knowledge which follows from recent science. During this thesis we will use methods such as: comparison, analysis and synthesis. Main aim of this thesis will be to deal with the following question: what relationship can be observed between empathy, "moral sense" and ethical behaviour in perspective of recent science. This enquiry will therefore try to deal with the old question: what the the relationship between reason, passions and ethical behaviour is.
Suárez's Proof of the Existence of God
Pavlorek, David ; Novák, Lukáš (advisor) ; Němec, Václav (referee)
of the Paper The goal of submitted paper is to show Suárez's proof of the existence of God as the main task of his metaphysics and to show the influence of St. Thomas Aquinas and John Duns Scotus on his own system of metaphysics. As will be shown, the importance of this preeminent thinker of so called second scholasticism is in his synthesis of relatively incompatible doctrines of thomism and scotism. This paper will therefore deal with main problems of precedening tradition of Aristotelian metaphysics, especially with analogy of being as applied to God and creatures, then with theory of causality and other connected questions. Keywords Suárez - Thomas Aquinas - Duns Scotus - metaphysics - proof of existence of God
A Comparison of Plotinus's and St. Augustine's Conception of Evil
Košová, Michaela ; Němec, Václav (advisor) ; Novák, Lukáš (referee)
This bachelor thesis is concerned with Plotinus's and Augustine's conception of evil and its main aim is to compare both views and reveal which Plotinus's thoughts inspired Augustine and at which points he had to divert from Plotinus. The key question is in what way both philosophers attempt to answer the question about ontological status and origin of evil. While examining the differences between both conceptions it will be importatnt to explain them with regard to different metaphysical concepts which constitute Plotinus's and Augustine's thinking. First part of the thesis investigates in what sense in Plotinus's theory matter - the last point of emanation of reality from the One - is the principle of evil. Later we encounter tolma, certain illegitimate audacity to become independent from the higher levels which is present in the soul and also at the very emergence of reality as such from the One. However, since soul has a divine origin, it cannot really sin. Plotinus ascribes the ultimate responsibility for evil to matter, utter privation and form of non-being, which can act as a sort of trap for the soul. In the second part we will see that thanks to neoplatonic thinking Augustine too perceives evil as privation but he ascribes its origin to a free decision of created, and thus mutable rational...
Selecting an information System for the Company VAMCORP GROUP, spol. s r.o.
Rychtecký, Michal ; Novák, Lukáš (referee) ; Koch, Miloš (advisor)
Subject matter of this diploma thesis is selection of a suitable information system which purpose will be to improve processes and competitiveness of a company VAMCORP GROUP, spol. s.r.o. The thesis will analyze business requirements which need to be met by specific information system and compare possibilities for its acquisition. Each information system will be described. Based on attributes set by observed company the most suitable one will be selected. An implementation procedure will be proposed for the selected information system, including a risk analysis related to its implementation and the operation itself. The number of risks will be reduced by propounding befitting measures. Appropriate measures to minimize them will be proposed for individual risks. Subsequently, costs associated with the implementation and operation of selected information system will be quantified. In conclusion will be summarized the content of the thesis accompanied by enumeration of benefits which will be brought by selected information system to observed company.
Assessing the Effectiveness of the Information System in a Company Dealing with Localization and Proposal of Changes
Straka, Václav ; Novák, Lukáš (referee) ; Koch, Miloš (advisor)
This diploma thesis deals with the review of the current state of the information system in the firm, which focuses on localisation. The paper defines theoretical terms which are necessary to in order to understand the area of information systems with regard to its structure and operating. The environment of the firme is described together with the analysis of the information systém in use. With the information collected from the analyses and the questionere we are able to identify the risk areas. The identified risks are treated on the basis of severity by proposing changes and then economically evaluated.

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