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Growth hormone - IGF - 1 axis, it's regulation and function. Plasma ghrelin levels in certain pathologic states
Jarkovská, Zuzana ; Marek, Josef (advisor) ; Hainer, Vojtěch (referee) ; Mareš, Jan (referee)
Ghreliu is a peptide hormone with a strong stimulatory effect on growth hormone (GH) secretion. Ghrelin was origiu;i!íy isolated from the rat stomach as an endogenous secretagogue for the growth hormone secretagogue receptor (GHS-R). Although the fírst coinpoimds of the group of growth hormone seeretagogues were synthesized already in 1997, the isolation of the GHS-R and ghrelin is a matter of tlie last decade. Our study was aimed at the determination of the physiological role of endogenous ghrelin in GH secretion in certain pathological conditions and its associations with tlie GH/IGF-1 axis compounds. Our study was the first one detecíing also active ghrelin coucentrations. We assumed, that ghrelin secretion is aflected by the GH secretory statě. In patíents with acroinegaly we expected low ghrelin coucentrations (hypothesis 1) aud in patients with GHD we presuined, that ghrelin concentrations will be elevated (hypothesis 2) in comparison with healthy subjects as an effect of the negative feedback regulation by GH. Our findings however did not support tliese hypotheses, active and total ghrelin concentrations did not differ between patients and healthy controls. These data do not support an important role tor ghrelin in GH secretion in these conditions as well as the existence of a negative feedback...
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Business plan – climbing center
Knot, Martin ; Habrmanová, Blanka (advisor) ; Mareš, Jan (referee)
This Master´s thesis deals with creating a business plan, which covers the construction of a climbing centre in Vrchlabí. The goal of the thesis is to assess the feasibility of the project based on the created business plan. The thesis is divided into two main parts. The first, theoretical part, deals with a difference between an entrepreneur and a relationship of employment, reasons to run a business, but above all, reasons for creating a business plan and its structure. The practical part includes a business plan itself with a detailed structure of the whole project, a financial plan and all necessary steps and actions that need to be done for its successful realization. The greatest emphasis is placed on the analysis of potential customers as a key factor of the success of the project. Evaluation of the project profitability and success in existing conditions comes in the conclusion of the thesis.
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Podnikatelský plán - Využití atraktivity kontaktu s farmářskými zvířaty jako zdroje udržitelného byznisu v turismu
Kružliak, Ľubomír ; Lukeš, Martin (advisor) ; Mareš, Jan (referee)
The goal of this thesis is to develop a sustainable and realistic business plan for the development of a tourist attraction based around the contact between visitors and farm animals. The thesis consists of the evaluation of tourism and agrotourism in Slovakia and in the region of Liptov, followed by the secondary research on agrotourism attractions. The selection of target groups, followed by primary market research and its evaluation, analysis of strategic partners and location, as well as the operations, marketing, and financials are presented in this thesis. The data presented prove that the business idea of creating a tourist attraction featuring farm animals is a viable tourist platform to build a business upon. The contingencies and risks are also analyzed resulting in a complete and viable business plan.
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Copycats among internet-based companies: Success via imitation
Niklyaev, Ilya ; Lukeš, Martin (advisor) ; Mareš, Jan (referee)
This study is dedicated to providing readers with a holistic overview of the phenomenon of the imitation among internet based companies. Four research questions have been posed and answered through qualitative primary and secondary researches. As a result of this study major success factors that allowed a Berlin - based company Rocket Internet SE to imitate ideas and business models of others have been identified, numerous recommendations have been provided to future copycat companies as well as to companies that face the pressure from such copycats in their day-to-day activities. As an outcome, more transparency has been provided about the processes of imitation in the business environment in order to allow various players to compete more effectively, structure their operations in more efficient way and avoid costly mistakes.
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Innovations in the Banking sector
Khachukaeva, Bella ; Špaček, Miroslav (advisor) ; Mareš, Jan (referee)
The aim of this thesis is to propose improvements in the selected banking process. This thesis consists of a theoretical and a practical part. The theoretical part is devoted to the traditional and banking approaches to innovations. The definition of innovations, classification, sources, models of innovation process, barriers to innovations are defined in the theoretical part. The practical part is devoted to the analysis of the process and a proposal of the innovation model of the process.
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Business plan
Bláhová, Karolína ; Svobodová, Ivana (advisor) ; Mareš, Jan (referee)
This thesis focuses on developing a business plan for the production of baby food. The thesis consists of three parts. The main purpose of the theoretical part is to introduce the reader the environment of small and medium enterprise subsequently to describe the proper writing of a business plan. There are also recommendations for suitable structures procedures. Methodical part deals with the proper execution of marketing research, considerable attention particularly a method of interrogation. The practical part is the business plan itself. The aim of this thesis is to evaluate the feasibility of the project and its ability to prosper at today's market.
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FITkit as a Programmer of Microcontrollers
Mareš, Jan ; Strnadel, Josef (referee) ; Vašíček, Zdeněk (advisor)
This thesis explores the possibilites of using FITkit as a programmer of Microchip PIC and Atmel AVR microcontrollers. It describes methods of microcontroller programming and procedures that need to be followed to program a microcontroller. It also details the implementation of a FPGA design able to program these microcontrollers and a corresponding application for PC. At last, it evaluates the results, with focus at programming speed.
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Business Plan of the Trilobit hotel
Latash, Alena ; Habrmanová, Blanka (advisor) ; Mareš, Jan (referee)
The goal of the thesis is is to present a business plan for new Trilobit hotel, conduct analysis of its marketing activities and determine strategies of development to promote the services of this hotel. SWOT analysis was used and showed that the hotel has more strength than weaknesses; also there are a lot of opportunities for development. Competitive analysis defined the hotel as the best in that area. All tools of marketing mix were explained clearly and in detail. Implementation plan and financial computations were placed to show costs, investments and cash flow. Range of development strategies was offered. In case of implementing that, hotel will attract new customers, extend range of services and increase competitive advantage and profitability.
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Business plan of a personal agency focused on IT
Strapatý, Michal ; Habrmanová, Blanka (advisor) ; Mareš, Jan (referee)
The diploma thesis is focused on the topic of creation a business plan for a personal agency with specialization on information technology industry. There are described general rules of writing the business plan as well as specifics of personal agencies in the theoretical part. The practical part applies this theoretical knowledge on the specific case and there is also a feasibility analysis of such a project. Practical part follows the theoretical one and applies the knowlege sucha s marketing plan, financial plan etc. on the specific project. There is also analysis of micro and macro environment.
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Franchising as a method of entrepreneurship in gastronomy: Analysis of the Potrefená husa concept
Drápela, Lukáš ; Lukeš, Martin (advisor) ; Mareš, Jan (referee)
Bachelor Thesis is focused on franchising as method of entrepreneurship in gastronomy in Czech Republic. Author tries to cover the history and current state of this young and comparatively publicly unknown method. Thesis starts with the main symbols of franchising, his history and legal side of it in Czech Republic with stress on the gastronomy field. Practical part aims on analysing the Potrefená husa franchise concept, one of the oldest and the most successful in Czech Republic beyond fast-foods. Using qualitative research, specifically individual deep interviews, author tries to identify the key factors of the success and describe the weak sides of the concept as well. Thesis might be used as a feedback for stakeholders or as material for potential franchisants, considering admission to concept.
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