|
| |
|
|
Glucose metabolism abnormalities induced by central nervous system injury and pharmacotherapy influence on them
Kudláčková, Zdeňka
In our paper we were interested in abnormalities of glycide metabolism. The experiments were performed in normotensive male and female rats of Wistar strain as well as male and female rats of Koletsky strain. Glucose intolerance was induced in both of strains by brain ischemia (4 hours of occlusion of both common carotid arteries followed by 44-hour-reperfusion). Brain water content was used as a marker of brain edema. The effect of terguride (trans-dihydrolisuride) was tested. Brain ischemia induced glucose intolerance and brain edema in both strains of rats. Basal glycaemia was not changed by the brain ischemia in male and female rats of Koletsky strain, except female rats of the age from 5-6 months. Basal glycaemia was changed by the brain ischemia in female rats of Wistar strain, except female rats of the age of 5-6 months and in male rats of Wistar strain it was not changed, except animals of the age from 7-8 months. When we compared the effect of brain ischemia on "area under the glucose tolerance curve", we found statistically significant increase of AUC in both sexes of both strains. Long lasting terguride treatment of glycide metabolic abnormalities shows ambivalent effect. Terguride decreased statistically significant glycaemia in male rats of Wistar strain by 42,32% and in females of this...
|
|
|
Environment and asthma bronchiale
Horová, Zuzana ; Jílek, Petr (advisor) ; Kudláčková, Zděnka (referee)
BACKGROUND: Asthma is one of the most often occuring children chronic diseases and its prevalence is steadily increasing. A lot of risk and protective factors influencing the development of asthma and atopic diseases have been described. It is necessary to gain more information about these factors, though. AIM: To compare two different groups of children (the asthmatics and the reference group) beeing influenced by different risk and protective factors for developing asthma. Analysing the risk factors may help us to design preventive programmes and broaden the knowledge of pathobiology of the disease. METHODS: 3848 structured anonymous questionnaires were sent to various primary schools round the Czech Republic. The questionnaires were completed by parents on behalf of their children. The aim of the questionnaires was to examine the prenatal conditions and postnatal conditions at the age of the first two years, at 6th -7th , 12th - 13th year of age. In this study we focused on postnatal conditions of children. 2050 completed questionnaires were sent back and we focused on the group of 118 astmatic children and 765 non-allergic children as the reference group. Children were born in years 1992-1993 and all come from the Czech Republic. Answering positively the question about asthmatic symptoms and...
|
|
|
Predisposal factors for the development of rhinitis
Babrňáková, Lenka ; Jílek, Petr (advisor) ; Kudláčková, Zděnka (referee)
Babrňáková Lenka - Predisposing factors of rhinitis, Univerzita Karlova v Praze, Farmaceutická fakulta v Hradci Králové, 2009 AABBSSTTRRAACCTT BACKGROUND: Rhinitis is one of the causes of the later asthma-expansion. This disease is very vexatious and has a negative impact on the quality of life. The prevalence steadily rises not only in childhood. Many risk and protective factors that are very important for the expansion of atopic diseases and rhinitis have been described. OBJECTIVES: To compare two child populations (rhinitics and the reference sample) with different risk and protective factors influencing the expansion of rhinitis. Thanks to the recognition of the risk factor we can project relevant preventive plans and ímprove our general knowledge in this type of disease. METHODS: 3845 anonymous and structured questionnaires were distributed at the Czech basic schools. The parents filled in the questionnaires on behalf of their children. The questionnaires were supposed to find out the pregnancy conditions of a mother and the living conditions of a child during three periods (first two years of life, the 6th and the 7th year, the 12th and and 13th year). 2050 filled questionnaire were delivered and the analysis was focused on the group of 334 rhinitic children and 765 nonallergic children. We call a...
|
|
| |
|
|
Pathophysiology of brain trauma.
Chovančík, Josef ; Kudláčková, Zděnka (advisor) ; Herink, Josef (referee)
Author: Josef Chovančík Title of diploma thesis: Trauma and pathophysiological of brain damage Form: Master Thesis Name of University: Charles University in Prague Faculty of Pharmacy in Hradec Králové Department of Biological and Medical Sciences Field: Pharmacy Background: Work in the first part describes the construction of the nervous and vascular system at key points which relate to the topic. Focuses on basic functional principles of both systems, which together are both anatomically and functionally linked. In its special section then discusses his own brain injury. Includes incidence, causes and mechanisms of its formation, classify its severity. Describes the pathophysiological processes in the brain injury that are the focus of today's scientific research. Findings and conclusion: Based on the work of our search, we concluded that the pathophysiological picture of cerebral tissue damage involves many, mutually interlocking mechanisms. We found that the toxic effect of excitatory amino acids leads to a massive increase in intracellular calcium concentration. The resulting stepped-pathological activation of many enzymes and inhibition of mitochondrial function. Damage to nerve cells is also caused by free radicals that cause damage to cell membranes, proteins and molecular genetic...
|
|
| |
|
| |
|
| |
|
| |
guest ::
